Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer’s disease

Ma, Suk Ling; Ng, Ho Keung; Baum, Larry; Pang, Jesse Chung Sean; Chiu, Helen Fung Kum; Woo, Jean; Tang, Nelson Leung Sang; Lam, Linda Chiu Wa

doi:10.1016/s0304-3940(02)00942-4

Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer’s disease

Apolipoprotein E (ApoE) isoforms affect the risk of developing Alzheimer's disease (AD). ApoE-associated risk may be related to its binding to and clearance by cell surface receptors, such as the members of the low-density lipoprotein (LDL) receptor family. Previous studies had shown association …