Human Apolipoprotein E Receptor 2
Open accessAbstract
Isolation and characterization of a human cDNA demonstrated a novel lipoprotein receptor designated apolipoprotein E receptor 2 (apoER2). The new receptor consists of five functional domains resembling the low density lipoprotein (LDL) and very low density lipoprotein (VLDL) receptors. LDL receptor deficient Chinese hamster ovary cells expressing human apoER2 bound apoE rich beta-migrating VLDL with high affinity and internalized. LDL was bound with much lower affinity to these cells. The 4.5- and 8.5-kb mRNAs for the receptor were most highly expressed in human brain and placenta. In rabbit tissues, multiple species of the mRNA with 4, 4.5, 5.5, 8.5, and 11 kb were detected most intensely in brain and testis and, to a much lesser extent, in ovary, but were undetectable in other tissues. In rat adrenal pheochromocytoma PC12 cells, the receptor mRNA was induced by treatment of the cells with nerve growth factor. The receptor transcripts were detectable most intensely in the cerebellar cortex, choroid plexus, ependyma, hippocampus, olfactory bulb and, to a much lesser extent, in the cerebral cortex as revealed by in situ hybridization histochemistry. In the cerebellar cortex, the receptor transcripts were densely deposited in Purkinje cell somata.
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ApoER2 is a member of the LDL-R family.
“ApoER2 is a member of the LDL-R family that is expressed in neurons, platelets, ovaries, epididymis, placenta and brain [1], [2], [3].”
From Sorting nexin 17 regulates ApoER2 recycling and reelin signaling (2014) · cites this paper as [1]
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- Authors
- Kim, D.-H., Iijima, H., Goto, K., Sakai, J., Ishii, H., Kim, H.-J., Suzuki, H., Kondo, H., Saeki, S., & Yamamoto, T.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Yamamoto, Tokuo
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 271
- Issue
- 14
- Pages
- 8373-8380
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1576213701
- Cited by
- 384
- References
- 1
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 13 · 2016: 5 · 2015: 6 · 2014: 16 · 2013: 5 · 2012: 13
- FWCI
- 36.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- ApoER2, lipoprotein receptors, cDNA cloning, LDL binding, receptor internalization, receptor mRNA expression, brain, placenta, cerebellar cortex, Purkinje cells, choroid plexus, ependyma, hippocampus, olfactory bulb, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Brain, Cricetinae, Humans, Ligands, Molecular Sequence Data, Receptors, LDL, Recombinant Proteins, RNA, Messenger, Gene Expression, Sequence Alignment, CHO Cells, Sequence Homology, Amino Acid, DNA, Complementary, Receptors, Lipoprotein, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-1, Rats
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