Cited by 92Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

Arai, Tetsuaki, Nonaka, Takashi, Hasegawa, Masato, Akiyama, Haruhiko, Yoshida, Mari, Hashizume, Yosio, Tsuchiya, Kuniaki, Oda, Tatsuro +1 more·2003·Neuroscience Letters

Abstract

We examined the immunoreactivity of p62 in five cases of frontotemporal dementia (FTD) with ubiquitin-positive, tau-negative inclusions. Only one case had clinical features suggestive of motor neuron disease (MND). In all cases, ubiquitin-positive neuronal inclusions and neurites in the hippocampal region and cerebral neocortex were immunohistochemically positive for p62. Moreover, in the temporal region of a case of FTD with MND, many oligodendrocytes and some astrocytes were positive for p62. These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells.

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Crossref · 10.1016/s0304-3940(03)00216-7

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  • SQSTM1-positive inclusions are found in the majority of patients with ALS and FTD and often overlap with inclusions that stain for ubiquitin and TARDBP/TDP-43.

    “Furthermore, SQSTM1-positive inclusions are found in the majority of patients with ALS and FTD, and often overlap with inclusions that stain for ubiquitin and TARDBP/TDP-43 (TAR DNA binding protein), an essential RNA-binding protein integrally connected with ALS-FTD [82,116–118] (Figure 1).”

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Authors
Arai, T., Nonaka, T., Hasegawa, M., Akiyama, H., Yoshida, M., Hashizume, Y., Tsuchiya, K., Oda, T., & Ikeda, K.
Affiliations
  • Tokyo Institute of Psychiatry (JP)
  • Aichi Medical University (JP)
  • Tokyo Metropolitan Matsuzawa Hospital (JP)
Corresponding author
Arai, Tetsuaki
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2003-05
Volume
342
Issue
1-2
Pages
41-44
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2057801189
Cited by
92
References
20
Citations by year
2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 9 · 2013: 1 · 2012: 5
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
frontotemporal dementia, motor neuron disease, p62, ubiquitin-positive inclusions, neuronal inclusions, glial inclusions, oligodendrocytes, astrocytes, hippocampus, neocortex, neurodegeneration
MeSH terms
Sequestosome-1 Protein, Aged, Aged, 80 and over, Astrocytes, Autopsy, Dementia, Female, Fluorescent Antibody Technique, Frontal Lobe, Humans, Immunohistochemistry, Male, Middle Aged, Motor Neurons, Neuroglia, Neurons, Oligodendroglia, Temporal Lobe, Adaptor Proteins, Signal Transducing

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