Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
Abstract
We examined the immunoreactivity of p62 in five cases of frontotemporal dementia (FTD) with ubiquitin-positive, tau-negative inclusions. Only one case had clinical features suggestive of motor neuron disease (MND). In all cases, ubiquitin-positive neuronal inclusions and neurites in the hippocampal region and cerebral neocortex were immunohistochemically positive for p62. Moreover, in the temporal region of a case of FTD with MND, many oligodendrocytes and some astrocytes were positive for p62. These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells.
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SQSTM1-positive inclusions are found in the majority of patients with ALS and FTD and often overlap with inclusions that stain for ubiquitin and TARDBP/TDP-43.
“Furthermore, SQSTM1-positive inclusions are found in the majority of patients with ALS and FTD, and often overlap with inclusions that stain for ubiquitin and TARDBP/TDP-43 (TAR DNA binding protein), an essential RNA-binding protein integrally connected with ALS-FTD [82,116–118] (Figure 1).”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [116]
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- Authors
- Arai, T., Nonaka, T., Hasegawa, M., Akiyama, H., Yoshida, M., Hashizume, Y., Tsuchiya, K., Oda, T., & Ikeda, K.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- Aichi Medical University (JP)
- Tokyo Metropolitan Matsuzawa Hospital (JP)
- Corresponding author
- Arai, Tetsuaki
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 342
- Issue
- 1-2
- Pages
- 41-44
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2057801189
- Cited by
- 92
- References
- 20
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 9 · 2013: 1 · 2012: 5
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- frontotemporal dementia, motor neuron disease, p62, ubiquitin-positive inclusions, neuronal inclusions, glial inclusions, oligodendrocytes, astrocytes, hippocampus, neocortex, neurodegeneration
- MeSH terms
- Sequestosome-1 Protein, Aged, Aged, 80 and over, Astrocytes, Autopsy, Dementia, Female, Fluorescent Antibody Technique, Frontal Lobe, Humans, Immunohistochemistry, Male, Middle Aged, Motor Neurons, Neuroglia, Neurons, Oligodendroglia, Temporal Lobe, Adaptor Proteins, Signal Transducing
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