Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

Clement, Albrecht M.; Sugahara, Kazuyuki; Faissner, Andreas

doi:10.1016/s0304-3940(99)00432-2

Cited by 127Proteoglycans and glycosaminoglycans researchNerve injury and regenerationAxon Guidance and Neuronal Signaling

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

Clement, Albrecht M., Sugahara, Kazuyuki, Faissner, Andreas·1999·Neuroscience Letters

DOI 10.1016/s0304-3940(99)00432-2

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Abstract

In light of controversial reports concerning the effects of chondroitin sulfates on neurite outgrowth, several glycosaminoglycans belonging to this structural class were compared with regard to their influence on axon formation by embryonic day 18 hippocampal neurons. In these studies, chondroitin sulfate A (CS-A), CS-B and CS-C proved weak or inefficient in the neurite outgrowth promotion assay. As expected, CS-D stimulated both the fraction of neurite bearing neurons and the length of their processes. This effect could be neutralized by the monoclonal antibody (mAb) 473HD. In contrast, CS-E enacted a dramatic promotion of neurite outgrowth. This effect persisted in the presence of mAb 473HD, consistent with the observation that this antibody did not react with CS-E in glycosaminoglycan transfer and blotting techniques. We conclude that CSE contains a novel glycosaminoglycan based neurite outgrowth promoting motif, which is distinct from other known activities.

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The 2S6S-CS isomer is a critical variant shown to exhibit neuroregenerative properties, including increasing neurite bearing neurons, process length, and outgrowth in hippocampal cell cultures.
“Since the 2S6S-CS isomer is a critical variant shown to exhibit neuroregenerative properties, including increasing neurite bearing neurons (Clement et al. 1999), process length (Clement et al. 1999), and outgrowth in hippocampal cell cultures (Shida et al. 2019)”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Clement et al. 1999

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Authors: Clement, A. M., Sugahara, K., & Faissner, A.
Affiliations: Heidelberg University (DE)
Kobe Pharmaceutical University (JP)
ORCID: Clement, Albrecht M.
Sugahara, Kazuyuki
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1999-07
Volume: 269
Issue: 3
Pages: 125-128
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/s0304-3940(99)00432-2
OpenAlex: W2053191670
Cited by: 127
References: 25
Citations by year: 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: chondroitin sulfate E, neurite outgrowth, hippocampal neurons, glycosaminoglycans, axon formation, neurite length
MeSH terms: Animals, Antibodies, Monoclonal, Axons, Cell Differentiation, Cells, Cultured, Chondroitin Sulfates, Embryo, Mammalian, Hippocampus, Neurons, Peptides, Neurites, Rats

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Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

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