Developmental Regulation of the Sulfation Profile of Chondroitin Sulfate Chains in the Chicken Embryo Brain
Open accessAbstract
Developmentally regulated and cell type-specific expression of distinct sulfated glycosaminoglycan structures on cell surface proteoglycans is increasingly recognized as providing information relevant to cell-cell interactions and differentiation in developing organisms. In this report, developmental regulation of both the sulfation profile of chondroitin sulfate chains and activities of chondroitin 4-sulfotransferase (C4ST) and chondroitin 6-sulfotransferase (C6ST) were evaluated in embryonic chicken brain. The results revealed that the sulfation profile and the sulfotransferase activities changed markedly with development, and these alterations were precisely coordinated. Specifically, the proportions of both chondroitin 6-sulfate to 4-sulfate and C6ST to C4ST activities progressively decreased with development. In addition, the total amounts of both chondroitin sulfate chains and the sulfotransferase activities were highest during early embryonic stages and decreased sharply as the development reached completion. The developmental expression of the C6ST gene was also found to parallel the developmental down-regulation of both the C6ST activity and the chondroitin 6-sulfate structure. These findings suggest that the developmentally regulated expression of the sulfotransferases is a predominant factor for stage-specific regulation of chondroitin sulfate structures.
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There is a substantial increase in the 4-sulfation/6-sulfation (C4S/C6S) ratio during brain development.
“Overall then, there is a substantial increase in the 4--sulfation/6-sulfation (C4S/C6S) ratio during brain development (Kitagawa et al., 1997;Miyata et al., 2012).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Kitagawa et al., 1997
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Self-citationPersistent cortical plasticity by upregulation of chondroitin 6-sulfation
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- Authors
- Kitagawa, H., Tsutsumi, K., Tone, Y., & Sugahara, K.
- Affiliations
- Kobe Pharmaceutical University (JP)
- Corresponding author
- Sugahara, Kazuyuki
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 272
- Issue
- 50
- Pages
- 31377-31381
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2005960069
- Cited by
- 187
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 7 · 2012: 4
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Mizutani Foundation for Glycoscience
- Japan Private School Promotion Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- chondroitin sulfate, sulfotransferase activity, embryonic brain development, chick embryo, proteoglycans, glycosaminoglycans, developmental regulation, gene expression, chondroitin-6-sulfate, chondroitin 4-sulfate
- MeSH terms
- Carbohydrate Sulfotransferases, Animals, Brain, Chick Embryo, Chondroitin Sulfates, Disaccharides, Sulfates, Sulfotransferases, Down-Regulation, Gene Expression Regulation, Enzymologic
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