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Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons
Abstract
In light of controversial reports concerning the effects of chondroitin sulfates on neurite outgrowth, several glycosaminoglycans belonging to this structural class were compared with regard to their influence on axon formation by embryonic day 18 hippocampal neurons. In these studies, chondroitin sulfate A (CS-A), CS-B and CS-C proved weak or inefficient in the neurite outgrowth promotion assay. As expected, CS-D stimulated both the fraction of neurite bearing neurons and the length of their processes. This effect could be neutralized by the monoclonal antibody (mAb) 473HD. In contrast, CS-E enacted a dramatic promotion of neurite outgrowth. This effect persisted in the presence of mAb 473HD, consistent with the observation that this antibody did not react with CS-E in glycosaminoglycan transfer and blotting techniques. We conclude that CSE contains a novel glycosaminoglycan based neurite outgrowth promoting motif, which is distinct from other known activities.
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“Since the 2S6S-CS isomer is a critical variant shown to exhibit neuroregenerative properties, including increasing neurite bearing neurons (Clement et al. 1999), process length (Clement et al. 1999), and outgrowth in hippocampal cell cultures (Shida et al. 2019)”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Clement et al. 1999
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The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.
Serafini, T., Kennedy, T. E., Gaiko, M. J., Mirzayan, C., Jessell, T., & Tessier-Lavigne, M. (1994) · Cell · doi:10.1016/0092-8674(94)90420-0 · Cited by 1,397
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E., Chan, S., Culotti, J., & Tessier-Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81336-7 · Cited by 1,048
Regeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina
Brittis, P. A., Canning, D. R., & Silver, J. (1992) · Science · doi:10.1126/science.1738848 · Cited by 415
Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties.
Faissner, A., Clement, A. M., Lochter, A., Streit, A., Mandl, C., & Schachner, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.3.783 · Cited by 354
Self-citationInteractions of developing neurons with the extracellular matrix
Letourneau, P. C., Condic, M., & Snow, D. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-00915.1994 · Cited by 304
Redies, C., & Takeichi, M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0315 · Cited by 247
Kitagawa, H., Tsutsumi, K., Tone, Y., & Sugahara, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31377 · Cited by 187
Self-citationBrümmendorf, T., & Rathjen, F. G. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80089-4 · Cited by 175
Clement, A. M., Nadanaka, S., Masayama, K., Mandl, C., Sugahara, K., & Faissner, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28444 · Cited by 175
Self-citationBoundaries and inhibitory molecules in developing neural tissues
Faissner, A., & Steindler, D. A. (1995) · Glia · doi:10.1002/glia.440130402 · Cited by 159
Self-citationNadanaka, S., Clement, A. M., Masayama, K., Faissner, A., & Sugahara, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3296 · Cited by 150
Self-citationIn vitro control of neuronal polarity by glycosaminoglycans
Lafont, F., Rouget, M., Triller, A., Prochiantz, A., & Rousselet, A. (1992) · Development · doi:10.1242/dev.114.1.17 · Cited by 143
Götz, B., Scholze, A., Clement, A. M., Joester, A., Schütte, K., Wigger, F., Frank, R. W., Spieß, E., Ekblom, P., & Faissner, A. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.4.681 · Cited by 140
Self-citationCell and matrix specialisations of rhombomere boundaries
Heyman, I., Faissner, A., & Lumsden, A. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040308 · Cited by 130
Self-citationEmerling, D. E., & Lander, A. D. (1996) · Neuron · doi:10.1016/s0896-6273(00)80242-1 · Cited by 129
Proteoglycans in the nervous system
Lander, A. D. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90143-m · Cited by 114
Kinoshita, A., Yamada, S., Haslam, S. M., Morris, H. R., Dell, A., & Sugahara, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19656 · Cited by 93
Self-citationTelling Axons Where to Grow: A Role for Eph Receptor Tyrosine Kinases in Guidance
Brambilla, R., & Klein, R. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.0001 · Cited by 76
Fernaud-Espinosa, I., Nieto‐Sampedro, M., & Bovolenta, P. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.6.1437 · Cited by 67
The Semaphorins: A Family of Axonal Guidance Molecules?
Püschel, A. W. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01593.x · Cited by 66
Al-Hakim, A. H., & Linhardt, R. J. (1990) · Electrophoresis · doi:10.1002/elps.1150110106 · Cited by 50
PURIFICATION AND SOME PROPERTIES OF ACID MUCOPOLYSACCHARIDES OF BOVINE BRAIN
Saigo, K., & Egami, F. (1970) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1970.tb00543.x · Cited by 40
High-Resolution Imaging of the Self-Assembly of Organic Monolayers
Chiang, S. (1996) · Science · doi:10.1126/science.272.5265.1123 · Cited by 13
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Sugahara, K., & Kitagawa, H. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00125-1 · Cited by 423
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Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367
Self-citationDeepa, S. S., Umehara, Y., Higashiyama, S., Itoh, N., & Sugahara, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207105200 · Cited by 335
Self-citationProperzi, G., Carulli, D., Asher, R. A., Muir, E. M., Camargo, L. M., Kuppevelt, T. H. V., ten Dam, G. B., Furukawa, Y., Mikami, T., Sugahara, K., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03876.x · Cited by 190
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Metadata
- Authors
- Clement, A. M., Sugahara, K., & Faissner, A.
- Affiliations
- Heidelberg University (DE)
- Kobe Pharmaceutical University (JP)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 269
- Issue
- 3
- Pages
- 125-128
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2053191670
- Cited by
- 127
- References
- 25
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- chondroitin sulfate E, neurite outgrowth, hippocampal neurons, glycosaminoglycans, axon formation, neurite length
- MeSH terms
- Animals, Antibodies, Monoclonal, Axons, Cell Differentiation, Cells, Cultured, Chondroitin Sulfates, Embryo, Mammalian, Hippocampus, Neurons, Peptides, Neurites, Rats
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