The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Evidence for activation of microglia in patients with psychiatric illnesses
Abstract
Activation of microglia/macrophages is a key event in response to pathological changes in the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with activated microglia cells. In order to elucidate a potential role of microgliosis in severe psychiatric illnesses, post-mortem frontal cortex and hippocampus of patients with schizophrenia (n = 14) and affective disorder (n = 6) and control specimens (n = 13) were studied. Additionally Alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. All patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; Alzheimer's disease, four patients) in both gray and white matter. This finding provides evidence for distinct neuropathological changes in brains of patients with schizophrenia and affective disorder. The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses.
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“In this context, the neuropathology of schizophrenia has been reported to be closely associated with cytokines and microglial activation (Bayer et al., 1999; Brown, 2011; Juckel et al., 2011; Meyer et al., 2009; Monji et al., 2009; Najjar et al., 2013; Radewicz et al., 2000; Vuillermot et al., 2010).”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Bayer et al., 1999
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Depression as a Microglial Disease
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Metadata
- Authors
- Bayer, T. A., Buslei, R., Havas, L., & Falkai, P.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Bayer, Thomas A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 271
- Issue
- 2
- Pages
- 126-128
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2069782517
- Cited by
- 323
- References
- 19
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 13 · 2018: 26 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 26 · 2013: 27 · 2012: 18
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- microglial activation, HLA-DR, schizophrenia, mood disorders, bipolar disorder, Alzheimer's disease, postmortem brain, frontal cortex, hippocampus, neuroinflammation, brain immune response, neuropathology
- MeSH terms
- Aged, Mental Disorders, Female, HLA-DR Antigens, Humans, Immunohistochemistry, Macrophage Activation, Male, Middle Aged, Schizophrenia, Microglia, Mood Disorders
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