Cited by 323Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol

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Evidence for activation of microglia in patients with psychiatric illnesses

Bayer, Thomas A, Buslei, Rolf, Havas, Laszlo, Falkai, Peter·1999·Neuroscience Letters

DOI 10.1016/s0304-3940(99)00545-5

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Abstract

Activation of microglia/macrophages is a key event in response to pathological changes in the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with activated microglia cells. In order to elucidate a potential role of microgliosis in severe psychiatric illnesses, post-mortem frontal cortex and hippocampus of patients with schizophrenia (n = 14) and affective disorder (n = 6) and control specimens (n = 13) were studied. Additionally Alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. All patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; Alzheimer's disease, four patients) in both gray and white matter. This finding provides evidence for distinct neuropathological changes in brains of patients with schizophrenia and affective disorder. The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses.

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Authors: Bayer, T. A., Buslei, R., Havas, L., & Falkai, P.
Affiliations: University of Bonn (DE)
Corresponding author: Bayer, Thomas A
ORCID: Bayer, Thomas A
Buslei, Rolf
Falkai, Peter
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1999-08
Volume: 271
Issue: 2
Pages: 126-128
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/s0304-3940(99)00545-5
OpenAlex: W2069782517
Cited by: 323
References: 19
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 13 · 2018: 26 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 26 · 2013: 27 · 2012: 18
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: microglial activation, HLA-DR, schizophrenia, mood disorders, bipolar disorder, Alzheimer's disease, postmortem brain, frontal cortex, hippocampus, neuroinflammation, brain immune response, neuropathology
MeSH terms: Aged, Mental Disorders, Female, HLA-DR Antigens, Humans, Immunohistochemistry, Macrophage Activation, Male, Middle Aged, Schizophrenia, Microglia, Mood Disorders

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Evidence for activation of microglia in patients with psychiatric illnesses

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