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Cited by 439Glycosylation and Glycoproteins ResearchFungal and yeast genetics researchCarbohydrate Chemistry and Synthesis

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Overview of N- and O-linked oligosaccharide structures found in various yeast species

Gemmill, Trent R., Trimble, Robert B.·1999·Biochimica et Biophysica Acta (BBA) - General Subjects
DOI 10.1016/s0304-4165(98)00126-3
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Abstract

Yeast and most higher eukaryotes utilize an evolutionarily conserved N-linked oligosaccharide biosynthetic pathway that involves the formation of a Glc3Man9GlcNAc2-PP-dolichol lipid-linked precursor, the glycan portion of which is co-translationally transferred in the endoplasmic reticulum (ER) to suitable Asn residues on nascent polypeptides. Subsequently, ER processing glycohydrolases remove the three glucoses and, with the exception of Schizosaccharomyces pombe, a single, specific mannose residue. Processing sugar transferases in the Golgi lead to the formation of core-sized structures (Hex<15GlcNac2) as well as cores with an extended poly-alpha1,6-Man 'backbone' that is derivatized with various carbohydrate side chains in a species-specific manner (Hex50-200GlnNAc2). In some cases these are short alpha1,2-linked Man chains with (Saccharomyces cerevisiae) or without (Pichia pastoris) alpha1,3-Man caps, while in other yeast (S. pombe), the side chains are alpha1,2-linked Gal, some of which are capped with beta-1,3-linked pyruvylated Gal residues. Charged groups are also found in S. cerevisiae and P. pastoris N-glycans in the form of mannose phosphate diesters. Some pathogenic yeast (Candida albicans) add poly-beta1,2-Man extension through a phosphate diester to their N-glycans, which appears involved in virulence. O-Linked glycan synthesis in yeast, unlike in animal cells where it is initiated in the Golgi using nucleotide sugars, begins in the ER by addition of a single ma…

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Citations

Cites

Research works printed but not linked: 12

  1. Fukazawa, 1995, Curr. Top. Med. Mycol., 6, 189
  2. A.H. Rose, in: A.H. Rose (Ed.), The Yeasts, Vol. 2, 1st edn., Academic Press, New York, 1970, pp. 135–210.
  3. V. Farkas, in: A.H. Rose (Ed.), The Yeasts, Vol. 3, 2nd edn., Academic Press, New York, 1987, pp. 317–366.
  4. Whistler, 1958, Adv. Carbohydr. Chem., 13, 289
  5. M. Fukuda, A. Kobata (Eds.), Glycobiology: A Practical Approach, Oxford University Press, New York, 1993.
  6. P. Orlean, in: J.R. Pringle, J.R. Broach, E.W. Jones (Eds.), Molecular and Cell Biology of the Yeast Saccharomyces, Vol. 3, Cell Cycle and Cell Biology, Cold Spring Harbor Press, New York, 1997, pp. 229–362.
  7. Trimble, 1995, Trends Genet., 7, 1
  8. C. Alfa, P. Fantes, J. Hyams, M. McLeod, E. Warbrick (Eds.), Experiments with Fission Yeast, Cold Spring Harbor Laboratory Press, New York, 1993.
  9. F.Z. Ziegler, J. Cavanagh, C. Lubowski, R.B. Trimble, Glycobiology 9 (1998) in press.
  10. Gorin, 1968, Can. J. Chem., 46, 2299, 10.1139/v68-373 · DOI
  11. T.R. Gemmill, R.B. Trimble, Glycobiology 9 (1998) in press.
  12. Suzuki, 1997, Curr. Top. Med. Mycol., 8, 57

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Metadata

Authors
Gemmill, T. R., & Trimble, R. B.
Affiliations
New York State Department of Health (US)
Corresponding author
Trimble, Robert B.
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
1999-01
Volume
1426
Issue
2
Pages
227-237
ISSN
0304-4165 (ISSN-L)
DOI
10.1016/s0304-4165(98)00126-3
OpenAlex
W2007432405
Cited by
439
References
86
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 13 · 2021: 18 · 2020: 17 · 2019: 9 · 2018: 18 · 2017: 10 · 2016: 17 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 16
FWCI
5.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01gm023900-26)
  • U.S. Public Health Service
  • National Institute of General Medical Sciences (GM23900)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords
N-glycosylation, O-glycosylation, Candida albicans, Pichia pastoris, Schizosaccharomyces pombe, Saccharomyces cerevisiae, glycoside hydrolases
MeSH terms
Candida albicans, Carbohydrate Sequence, Glycoproteins, Glycosylation, Molecular Sequence Data, Oligosaccharides, Pichia, Saccharomyces cerevisiae, Schizosaccharomyces, Yeasts

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