The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Overview of N- and O-linked oligosaccharide structures found in various yeast species
Abstract
Yeast and most higher eukaryotes utilize an evolutionarily conserved N-linked oligosaccharide biosynthetic pathway that involves the formation of a Glc3Man9GlcNAc2-PP-dolichol lipid-linked precursor, the glycan portion of which is co-translationally transferred in the endoplasmic reticulum (ER) to suitable Asn residues on nascent polypeptides. Subsequently, ER processing glycohydrolases remove the three glucoses and, with the exception of Schizosaccharomyces pombe, a single, specific mannose residue. Processing sugar transferases in the Golgi lead to the formation of core-sized structures (Hex<15GlcNac2) as well as cores with an extended poly-alpha1,6-Man 'backbone' that is derivatized with various carbohydrate side chains in a species-specific manner (Hex50-200GlnNAc2). In some cases these are short alpha1,2-linked Man chains with (Saccharomyces cerevisiae) or without (Pichia pastoris) alpha1,3-Man caps, while in other yeast (S. pombe), the side chains are alpha1,2-linked Gal, some of which are capped with beta-1,3-linked pyruvylated Gal residues. Charged groups are also found in S. cerevisiae and P. pastoris N-glycans in the form of mannose phosphate diesters. Some pathogenic yeast (Candida albicans) add poly-beta1,2-Man extension through a phosphate diester to their N-glycans, which appears involved in virulence. O-Linked glycan synthesis in yeast, unlike in animal cells where it is initiated in the Golgi using nucleotide sugars, begins in the ER by addition of a single ma…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, these cells produce glycoproteins with high-mannose glycans structures, which may be immunogenic and less potent in humans (Dean, 1999;Gemmill and Trimble, 1999;Gerngross, 2004;Dumont et al., 2015).”
From Therapeutic glycoprotein production in mammalian cells (2017) · cites this paper as Gemmill and Trimble, 1999
Citations
Cites
Encyclopedia of plant physiology, New series
Harbörne, J. B. (1978) · Phytochemistry · doi:10.1016/s0031-9422(00)94191-8 · Cited by 2,036
The molecular machinery for secretion is conserved from yeast to neurons.
Bennett, M. K., & Scheller, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2559 · Cited by 650
PROTEIN GLYCOSYLATION IN YEAST
Kukuruzinska, M. A., Bergh, M. L. E., & Jackson, B. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.004411 · Cited by 439
Structure and Biosynthesis of the Mannan Component of the Yeast Cell Envelope
Ballou, C. E. (1976) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60227-1 · Cited by 333
The PMT gene family: protein O‐glycosylation in Saccharomyces cerevisiae is vital.
Gentzsch, M., & Tanner, W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00961.x · Cited by 250
High-Level Secretion of Glycosylated Invertase in the Methylotrophic Yeast, Pichia Pastoris
Tschopp, J. F., Sverlow, G. G., Kosson, R., Craig, W., & Grinna, L. S. (1987) · Nature Biotechnology · doi:10.1038/nbt1287-1305 · Cited by 246
Grinna, L. S., & Tschopp, J. F. (1989) · Yeast · doi:10.1002/yea.320050206 · Cited by 244
Stack, J. H., Horazdovsky, B. F., & Emr, S. D. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000245 · Cited by 183
Proton Magnetic Resonance Spectroscopy–An Aid in Identification and Chemotaxonomy of Yeasts
Gorin, P. A. J., & Spencer, J. F. T. (1970) · Advances in applied microbiology · doi:10.1016/s0065-2164(08)70400-3 · Cited by 177
Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action
Nelson, R. D., Shibata, N., Podzorski, R. P., & Herron, M. J. (1991) · Clinical Microbiology Reviews · doi:10.1128/cmr.4.1.1 · Cited by 167
Research works printed but not linked: 12
- Fukazawa, 1995, Curr. Top. Med. Mycol., 6, 189
- A.H. Rose, in: A.H. Rose (Ed.), The Yeasts, Vol. 2, 1st edn., Academic Press, New York, 1970, pp. 135–210.
- V. Farkas, in: A.H. Rose (Ed.), The Yeasts, Vol. 3, 2nd edn., Academic Press, New York, 1987, pp. 317–366.
- Whistler, 1958, Adv. Carbohydr. Chem., 13, 289
- M. Fukuda, A. Kobata (Eds.), Glycobiology: A Practical Approach, Oxford University Press, New York, 1993.
- P. Orlean, in: J.R. Pringle, J.R. Broach, E.W. Jones (Eds.), Molecular and Cell Biology of the Yeast Saccharomyces, Vol. 3, Cell Cycle and Cell Biology, Cold Spring Harbor Press, New York, 1997, pp. 229–362.
- Trimble, 1995, Trends Genet., 7, 1
- C. Alfa, P. Fantes, J. Hyams, M. McLeod, E. Warbrick (Eds.), Experiments with Fission Yeast, Cold Spring Harbor Laboratory Press, New York, 1993.
- F.Z. Ziegler, J. Cavanagh, C. Lubowski, R.B. Trimble, Glycobiology 9 (1998) in press.
- Gorin, 1968, Can. J. Chem., 46, 2299, 10.1139/v68-373 · DOI
- T.R. Gemmill, R.B. Trimble, Glycobiology 9 (1998) in press.
- Suzuki, 1997, Curr. Top. Med. Mycol., 8, 57
Cited by
Sorted by citations
The structure and synthesis of the fungal cell wall
Bowman, S. M., & Free, S. J. (2006) · BioEssays · doi:10.1002/bies.20441 · Cited by 1,320
Post-translational modifications in the context of therapeutic proteins
Walsh, G., & Jefferis, R. (2006) · Nature Biotechnology · doi:10.1038/nbt1252 · Cited by 1,007
Cell Wall Assembly in Saccharomyces cerevisiae
Lesage, G., & Bussey, H. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-05 · Cited by 849
Role of Glycosylation in Development
Haltiwanger, R. S., & Lowe, J. B. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074043 · Cited by 757
Yoshida, A., Kobayashi, K., Manya, H., Taniguchi, K., Kano, H., Mizuno, M., Inazu, T., Mitsuhashi, H., Takahashi, S., Takeuchi, M., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00070-3 · Cited by 706
Metadata
- Authors
- Gemmill, T. R., & Trimble, R. B.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Trimble, Robert B.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 1426
- Issue
- 2
- Pages
- 227-237
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2007432405
- Cited by
- 439
- References
- 86
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 13 · 2021: 18 · 2020: 17 · 2019: 9 · 2018: 18 · 2017: 10 · 2016: 17 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 16
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm023900-26)
- U.S. Public Health Service
- National Institute of General Medical Sciences (GM23900)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- N-glycosylation, O-glycosylation, Candida albicans, Pichia pastoris, Schizosaccharomyces pombe, Saccharomyces cerevisiae, glycoside hydrolases
- MeSH terms
- Candida albicans, Carbohydrate Sequence, Glycoproteins, Glycosylation, Molecular Sequence Data, Oligosaccharides, Pichia, Saccharomyces cerevisiae, Schizosaccharomyces, Yeasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
