The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology
Abstract
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism.
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Cites
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Cited by
The Somatomedin Hypothesis: 2001
Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., & Butler, A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,257
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Insulin-like growth factor signaling in fish
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Insulin-like growth factor-I and neurogenesis in the adult mammalian brain
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Exercise and gene expression: physiological regulation of the human genome through physical activity
Booth, F. W., Chakravarthy, M. V., & Spangenburg, E. E. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019265 · Cited by 277
Metadata
- Authors
- Butler, A. A., Yakar, S., Gewolb, I. H., Karas, M., Okubo, Y., & LeRoith, D.
- Venue
- Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 121
- Issue
- 1
- Pages
- 19-26
- ISSN
- 1096-4959 (ISSN-L)
- OpenAlex
- W2083227753
- Cited by
- 255
- References
- 59
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. https://app.cochat.ai/papers/10.1016/s0305-0491(98)10106-2
- The paper
- Butler, A. A., Yakar, S., Gewolb, I. H., Karas, M., Okubo, Y., & LeRoith, D. (1998). Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. https://doi.org/10.1016/s0305-0491(98)10106-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
