Social experience and social context alter the behavioral response to centrally administered oxytocin in female Syrian hamsters
Abstract
The type of social behavior displayed by an individual is profoundly influenced by its immediate social environment or context and its prior social experience. Although oxytocin is important in the expression of social behavior in several species, it is not known if social factors alter the ability of oxytocin to influence behavior. The purpose of the present study was to test the hypothesis that social experience and social context alter the ability of oxytocin to regulate flank marking (a form of scent marking) in female Syrian hamsters. Oxytocin was microinjected into the medial preoptic anterior hypothalamic continuum (MPOA-AH) of socially experienced, dominant female hamsters which were then tested with either a subordinate partner, with a novel partner, or alone. Oxytocin induced flank marking in a dose-dependent manner but only when the experienced dominant hamsters were tested with their familiar, subordinate partners. Oxytocin did not induce flank marking when injected into socially naive female hamsters that were tested with an opponent or alone. In males, by contrast, oxytocin induced flank marking in dominant hamsters when they were tested with their subordinate partner or alone. These data support the hypothesis that social experience and social context interact to regulate the ability of oxytocin to stimulate flank marking by its actions in the MPOA-AH in female hamsters.
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OXT induced flank marking when dominant female Syrian hamsters were tested with a familiar, but not with a novel, subordinate partner.
“OXT induced flank marking when dominant female Syrian hamsters were tested with a familiar, but not with a novel, subordinate partner (Harmon et al., 2002).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Harmon et al., 2002
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- Authors
- Harmon, A. C., Moore, T. O., Huhman, K. L., & Albers, H. E.
- Affiliations
- Georgia State University (US)
- Clark Atlanta University (US)
- Corresponding author
- Albers, H.E
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 109
- Issue
- 4
- Pages
- 767-772
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2055266348
- Cited by
- 30
- References
- 19
- Citations by year
- 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 3 · 2014: 3 · 2013: 4
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH62641, R01MH062641)
- National Institute of Neurological Disorders and Stroke (NS37234)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, social experience, social environment, flank marking, scent marking, medial preoptic area, anterior hypothalamus, dominance, social behavior, sex differences
- MeSH terms
- Animals, Behavior, Animal, Cues, Female, Cricetinae, Anterior Hypothalamic Nucleus, Learning, Male, Mesocricetus, Oxytocin, Preoptic Area, Sex Characteristics, Social Dominance
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