Cited by 112Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus

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Albers, HE, Pollock, J, Simmons, WH, Ferris, CF·1986·The Journal of Neuroscience

Abstract

A vasopressin-sensitive mechanism within the medial preoptic area-anterior hypothalamus (MPOA-AH) appears to be essential for expression of a complex behavior involved in olfactory communication in Golden hamsters called flank marking. The present study investigated whether the induction of flank marking by arginine-vasopressin (AVP) within the MPOA-AH is mediated by a receptor that is more similar to the vasopressor (V1) or the antidiurectic (V2) AVP receptor. Adult male hamsters were anesthetized and implanted with a 26 gauge guide cannula stereotaxically aimed at the MPOA-AH and then microinjected with analogs of vasopressin, oxytocin, and selective V1 and V2 antagonists. Hamsters were tested for flank-marking behavior during a 5 or 10 min observation period following the injection of peptide in a vehicle of 100 nl of saline. None of the 15 analogs of AVP and oxytocin produced more flank marking than the 50.8 +/- 16.2 and 76.8 +/- 4.4 (mean +/- SEM; n = 4) flank marks observed following injection of AVP at the 1 or 10 ng dose, respectively. The number of flank marks produced by each analog was found to be highly related to the pressor activity of that analog at both the 1 ng (rho = +0.74, p less than 0.01) and 10 ng (rho = +0.82, p less than 0.01) doses. In contrast, no statistically reliable relationship between flank marking and the antidiuretic activity of these analogs was found at either dose (1 ng: rho = +0.07, p greater than 0.05; 10 ng: rho = +0.10, p greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1523/jneurosci.06-07-02085.1986

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  1. Lawrence, J., P. Poulin, and K. Lederis (1984) The distribution and characterization of³H-vasopressin binding sites in the rat brain. Proc. West. Pharmacol. Soc. 27: 543-545.

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Authors
Albers, H., Pollock, J., Simmons, W., & Ferris, C.
Affiliations
University of Massachusetts Chan Medical School (US)
Venue
The Journal of Neuroscience
Published
1986-07-01
Volume
6
Issue
7
Pages
2085-2089
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1654983156
Cited by
112
References
30
Citations by year
2023: 3 · 2022: 5 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 4
FWCI
10.07
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (GM-34798)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-18022)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
vasopressin, V1 receptor, flank marking, olfactory communication, oxytocin, V1 receptor antagonist, vasopressin V2 receptor antagonist, pressor activity, antidiuretic activity
MeSH terms
Animals, Arginine Vasopressin, Behavior, Animal, Dose-Response Relationship, Drug, Cricetinae, Hypothalamus, Male, Mesocricetus, Oxytocin, Receptors, Angiotensin, Receptors, Cell Surface, Vasopressins, Receptors, Vasopressin

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