A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus
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A vasopressin-sensitive mechanism within the medial preoptic area-anterior hypothalamus (MPOA-AH) appears to be essential for expression of a complex behavior involved in olfactory communication in Golden hamsters called flank marking. The present study investigated whether the induction of flank marking by arginine-vasopressin (AVP) within the MPOA-AH is mediated by a receptor that is more similar to the vasopressor (V1) or the antidiurectic (V2) AVP receptor. Adult male hamsters were anesthetized and implanted with a 26 gauge guide cannula stereotaxically aimed at the MPOA-AH and then microinjected with analogs of vasopressin, oxytocin, and selective V1 and V2 antagonists. Hamsters were tested for flank-marking behavior during a 5 or 10 min observation period following the injection of peptide in a vehicle of 100 nl of saline. None of the 15 analogs of AVP and oxytocin produced more flank marking than the 50.8 +/- 16.2 and 76.8 +/- 4.4 (mean +/- SEM; n = 4) flank marks observed following injection of AVP at the 1 or 10 ng dose, respectively. The number of flank marks produced by each analog was found to be highly related to the pressor activity of that analog at both the 1 ng (rho = +0.74, p less than 0.01) and 10 ng (rho = +0.82, p less than 0.01) doses. In contrast, no statistically reliable relationship between flank marking and the antidiuretic activity of these analogs was found at either dose (1 ng: rho = +0.07, p greater than 0.05; 10 ng: rho = +0.10, p greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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AVP acts on V1aRs to stimulate flank marking.
“Structure-activity studies as well as the central injection of highly selective V1a agonists and antagonists indicates that AVP acts on V1aRs to stimulate flank marking [59; 60].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [59]
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- Authors
- Albers, H., Pollock, J., Simmons, W., & Ferris, C.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1986-07-01
- Volume
- 6
- Issue
- 7
- Pages
- 2085-2089
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6568576
- OpenAlex
- W1654983156
- Cited by
- 112
- References
- 30
- Citations by year
- 2023: 3 · 2022: 5 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 4
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM-34798)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-18022)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, V1 receptor, flank marking, olfactory communication, oxytocin, V1 receptor antagonist, vasopressin V2 receptor antagonist, pressor activity, antidiuretic activity
- MeSH terms
- Animals, Arginine Vasopressin, Behavior, Animal, Dose-Response Relationship, Drug, Cricetinae, Hypothalamus, Male, Mesocricetus, Oxytocin, Receptors, Angiotensin, Receptors, Cell Surface, Vasopressins, Receptors, Vasopressin
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