The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus
Abstract
Long-term potentiation (LTP) in the dentate gyrus can be modulated and prolonged by emotional/motivational influences when concurrently activated. A similar effect on LTP can be obtained by stimulating the amygdala, suggesting that this limbic structure might be part of the neural system involved in behavioural reinforcement. To confirm this we have performed a series of experiments in which the basolateral amygdala was either temporary inactivated by injection of lidocaine or permanently lesioned electrolytically. Both manipulations completely blocked the reinforcing effect of a motivational stimulus (drinking after 24-h deprivation) on LTP at the perforant pathway-dentate gyrus synapses, whilst leaving intact the non-reinforced potentiation. These results demonstrate that the basolateral amygdala is a key structure within the system involved in the modulatory interaction between the affective status of the animal and the mechanisms of functional plasticity.
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Damage to, or inactivation of, the amygdala blocks stress effects on hippocampal LTP and spatial memory.
“damage to, or inactivation of, the amygdala blocks stress effects on hippocampal LTP and spatial memory (Almaguer-Melian et al. [214]; Kim et al. [154]; Korz and Frey [215]; Kim and Jung [21]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Almaguer-Melian et al. [214]
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Cites
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736
Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation
Frey, U., & Morris, R. G. M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01189-2 · Cited by 615
Seidenbecher, T., Reymann, K. G., & Balschun, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1494 · Cited by 154
Drinking after water deprivation prolongs “unsaturated” LTP in the dentate gyrus of rats
Seidenbecher, T., Balschun, D., & Reymann, K. G. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00352-6 · Cited by 44
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Research works printed but not linked: 8
- Almaguer, 2002, Aging impairs amygdala-hippocampus interactions involved in hippocampal LTP, Neurobiol Aging, 23, 319, 10.1016/S0197-4580(01)00278-0 · DOI
- Bergado, 2001, Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies, Neuroscience, 108, 1, 10.1016/S0306-4522(01)00520-6 · DOI
- Frey, 2001, Reinforcement of early-LTP in dentate gyrus by stimulation of the basolateral amygdala, J Neurosci, 21, 3697, 10.1523/JNEUROSCI.21-10-03697.2001 · DOI
- Jas, 2000, Lesioning the fimbria-fornix impairs basolateral amygdala induced reinforcement of LTP in the dentate gyrus, Brain Res, 861, 186, 10.1016/S0006-8993(00)02037-0 · DOI
- Matthies, 1989, Neurobiological aspects of learning and memory, Annu Rev Psychol, 40, 381, 10.1146/annurev.ps.40.020189.002121 · DOI
- McGaugh, 1997, Interaction of neuromodulatory systems in modulating memory storage, Behav Brain Res, 83, 31, 10.1016/S0166-4328(97)86042-1 · DOI
- Packard, 1994, Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes, Proc Natl Acad Sci USA, 91, 8477, 10.1073/pnas.91.18.8477 · DOI · Paper page
- Quirk, 1996, Emotional memory, Cold Spring Harbor Symp Quant Biol, 61, 247, 10.1101/SQB.1996.061.01.027 · DOI
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Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762
“According to the temporal dynamics model, the weak memory at 24 hours produced by minimal water maze training should be strengthened if training were to occur during phase 1, but not if training was to occur during phase 2.”
BackgroundRoozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445
Glucocorticoid effects on object recognition memory require training-associated emotional arousal
Okuda, S., Roozendaal, B., & McGaugh, J. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307803100 · Cited by 402
Diamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95
Metadata
- Authors
- Almaguer-Melian, W., Martínez-Martí, L., Frey, J. U., & Bergado, J. A.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- International Center of Neurologic Restoration (CU)
- Corresponding author
- Bergado, J.A
- ORCID
- Bergado, J.A
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 119
- Issue
- 2
- Pages
- 319-322
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2091667609
- Cited by
- 50
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, long-term potentiation, dentate gyrus, perforant path, lidocaine inactivation, electrolytic lesions, limbic system
- MeSH terms
- Amygdala, Analysis of Variance, Anesthetics, Local, Animals, Behavior, Animal, Drinking, Electric Stimulation, Hippocampus, Lidocaine, Male, Reinforcement, Psychology, Time Factors, Water Deprivation, Rats, Sprague-Dawley, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Rats
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