Evidence of increased dopamine receptor signaling in food-restricted rats

Carr, K.D; Tsimberg, Y; Berman, Y; Yamamoto, N

doi:10.1016/s0306-4522(03)00227-6

Cited by 167Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchRegulation of Appetite and Obesity

Evidence of increased dopamine receptor signaling in food-restricted rats

Carr, K.D, Tsimberg, Y, Berman, Y, Yamamoto, N·2003·Neuroscience

DOI 10.1016/s0306-4522(03)00227-6

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Abstract

It is well established that chronic food restriction enhances sensitivity to the rewarding and motor-activating effects of abused drugs. However, neuroadaptations underlying these behavioral effects have not been characterized. The purpose of the present study was to explore the possibility that food restriction produces increased dopamine (DA) receptor function that is evident in behavior, signal transduction, and immediate early gene expression. In the first two experiments, rats received intracerebroventricular (i.c.v.) injections of the D1 DA receptor agonist SKF-82958, and the D2/3 DA receptor agonist quinpirole. Both agonists produced greater motor-activating effects in food-restricted than ad libitum-fed rats. In addition, Fos-immunostaining induced by SKF-82958 in caudate-putamen (CPu) and nucleus accumbens (Nac) was greater in food-restricted than ad libitum-fed rats, as was staining induced by quinpirole in globus pallidus and ventral pallidum. In the next two experiments, neuronal membranes prepared from CPu and Nac were exposed to SKF-82958 and quinpirole. Despite the documented involvement of cyclic AMP (cAMP) signaling in D1 DA receptor-mediated c-fos induction, stimulation of adenylyl cyclase (AC) activity by SKF-82958 in CPu and Nac did not differ between groups. Food restriction did, however, decrease AC stimulation by the direct enzyme stimulant, forskolin, but not NaF or MnCl(2), suggesting a shift in AC expression to a less catalytically efficient isoform. Finally, food restriction increased quinpirole-stimulated [(35)S]guanosine triphosphate-gammaS binding in CPu, suggesting that increased functional coupling between D2 DA receptors and G(i) may account for the augmented behavioral and pallidal c-Fos responses to quinpirole. Results of this study support the hypothesis that food restriction leads to neuroadaptations at the level of postsynaptic D1 and D2 receptor-bearing cells which, in turn, mediate augmented behavioral and transcriptional responses to DA. The signaling pathways mediating these augmented responses remain to be fully elucidated.

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Administration of the D1R agonist SFK-82958 produced enhanced striatal activation.
“Administration of the D1R agonist SFK-82958 produced enhanced striatal activation”
From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Carr et al., 2003
Intracerebroventricular injection of the DR2 agonist quinpirole produced a more pronounced striatal neuronal activation in caloric restricted rats versus ad lib fed controls.
“Intracerebroventricular injection of the DR2 agonist quinpirole produced a more pronounced striatal neuronal activation in caloric restricted rats versus ad lib fed controls (Carr et al., 2003).”
From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Carr et al., 2003
Elevated D2Rs showed enhanced effector striatal coupling.
“and elevated D2Rs showed enhanced effector striatal coupling (Carr et al., 2003).”
From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Carr et al., 2003

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Gilliland, S. L., Alper, R. H., & Levant, B. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00124-2 · Cited by 5 · see citing works

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Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride
Frank, G. K., Bailer, U. F., Henry, S. E., Drevets, W., Meltzer, C. C., Price, J. C., Mathis, C. A., Wagner, A., Hoge, J., Ziolko, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.003 · Cited by 361 · see citing works
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Authors: Carr, K. D., Tsimberg, Y., Berman, Y., & Yamamoto, N.
Affiliations: New York University (US)
Corresponding author: Carr, K.D
ORCID: Carr, K.D
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2003-07
Volume: 119
Issue: 4
Pages: 1157-1167
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(03)00227-6
OpenAlex: W2066768129
Cited by: 167
References: 82
Citations by year: 2026: 1 · 2025: 9 · 2024: 7 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 8
FWCI: 3.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k01da000342-05)
National Institute on Drug Abuse (R01DA003956, K02 DA 00292, R01 DA03956, T32DA007254, K01 DA 00342, K02DA000292, T32 DA07254)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: dietary restriction, dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, quinpirole, SKF 82958, Fos expression, adenylate cyclase, cAMP signaling, G protein coupling, caudate-putamen, nucleus accumbens, globus pallidus, ventral pallidum, neural adaptation, drug sensitivity
MeSH terms: Adaptation, Physiological, Adenylyl Cyclases, Animals, Corpus Striatum, Dopamine, Food Deprivation, Gene Expression Regulation, Male, Motor Activity, Synaptic Transmission, Neurons, Nucleus Accumbens, Receptors, Dopamine, Signal Transduction, Up-Regulation, Guanosine 5'-O-(3-Thiotriphosphate), Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, GTP-Binding Proteins, Caloric Restriction, Rats

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Evidence of increased dopamine receptor signaling in food-restricted rats

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