Cited by 504Neural dynamics and brain functionVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Viewpoint: the core and matrix of thalamic organization

Jones, E.G·1998·Neuroscience

DOI 10.1016/s0306-4522(97)00581-2

Open this paper in CoChat — free account

Abstract

The integration of the whole cerebral cortex and thalamus during forebrain activities that underlie different states of consciousness, requires pathways for the dispersion of thalamic activity across many cortical areas. Past theories have relied on the intralaminar nuclei as the sources of diffuse thalamocortical projections that could facilitate spread of activity across the cortex. A case is made for the presence of a matrix of superficially-projecting cells, not confined to the intralaminar nuclei but extending throughout the whole thalamus. These cells are distinguished by immunoreactivity for the calcium-binding protein, D28K calbindin, are found in all thalamic nuclei of primates and have increased numbers in some nuclei. They project to superficial layers of the cerebral cortex over relatively wide areas, unconstrained by architectonic boundaries. They generally receive subcortical inputs that lack the topographic order and physiological precision of the principal sensory pathways. Superimposed upon the matrix in certain nuclei only, is a core of cells distinguished by immunoreactivity for another calcium-binding protein, parvalbumin, These project in highly ordered fashion to middle layers of the cortex in an area-specific manner. They are innervated by subcortical inputs that are topographically precise and have readily identifiable physiological properties. The parvalbumin cells form the basis for sensory and other inputs that are to be used as a basis for perception. The calbindin cells, especially when recruited by corticothalamic connections, can form a basis for the engagement of multiple cortical areas and thalamic nuclei that is essential for the binding of multiple aspects of sensory experience into a single framework of consciousness.

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(97)00581-2

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Calbindin D-28k and parvalbumin in the rat nervous system
Celio, M. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90091-h · Cited by 2,076
Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Electrophysiological properties of guinea‐pig thalamic neurones: an in vitro study.
Jahnsen, H., & Llinás, R. R. (1984) · Journal of Physiology · doi:10.1113/jphysiol.1984.sp015153 · Cited by 1,213
Ionic basis for the electro‐responsiveness and oscillatory properties of guinea‐pig thalamic neurones in vitro.
Jahnsen, H., & Llinas, R. H. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015154 · Cited by 1,081
Coherent 40-Hz oscillation characterizes dream state in humans.
Llinás, R., & Ribary, U. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2078 · Cited by 962
Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey
Jones, E. G., & Leavitt, R. Y. (1974) · The Journal of Comparative Neurology · doi:10.1002/cne.901540402 · Cited by 882
Self-citation
Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
Contreras, D., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00604.1995 · Cited by 700
A STUDY OF THALAMO-CORTICAL RELATIONS
Morison, R. S., & Dempsey, E. W. (1941) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1941.135.2.281 · Cited by 661
Diffuse projection systems: The integrative action of the thalamic reticular system
Jasper, H. H. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90213-8 · Cited by 596
Laminar Organization of Thalamic Projections to the Rat Neocortex
Herkenham, M. A. (1980) · Science · doi:10.1126/science.7352263 · Cited by 595

Show all 73 references

Research works printed but not linked: 7

Hunt, 1988, The exact distribution of striatally-projecting thalamic neurons in the monkey, Neurosci. Abstr., 14, 188
Jasper H. H. (1960) Unspecific thalamocortical relations. In Handbook of Physiology Section 1, Neurophysiology (eds Field J., Magoun H. W. and Hall V. E.), Vol. 2, pp. 1307–1321. Washington, DC, U.S.A.
Jones E. G. (1988) Modern views of cellular thalamic mechanisms. In Cellular Thalamic Mechanisms (eds Bentivoglio M. and Spreafico R.), pp. 1–22. Elsevier, Amsterdam.
Jones E. G. (1989) Defining the thalamic intralaminar nuclei in primates. In Neurologia e Scienze Base. Scritti in Onore di Giorgio Macchi (eds Gainotti G., Bentivoglio M., Bergonzi P. and Ferro F. M.), pp. 161–194. Università Cattolica del Sacre Cuore, Milan.
Lorente de Nó R. (1938) Cerebral cortex: architectonics, intracortical connections. In Physiology of the Nervous System (ed Fulton J. R.), pp. 274–301. Oxford, New York.
Steriade M., Jones E. G. and Llinás R. R. (1990) Thalamic Oscillations and Signalling. Wiley, New York.
Steriade M., Jones E. G. and McCormick D. A. (1997) Thalamus. Elsevier, Oxford.

Sorted by citations

Items 401–500 of 502

Tinnitus and the Somatosensory System
Møller, A. R., & Ridder, D. D. (2024) · Springer eBooks · doi:10.1007/978-3-031-35647-6_12 · Cited by 2
Overview of the Human Brain and Spinal Cord
ten Donkelaar, H. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-19134-3_1 · Cited by 2
Diencephalon: Dorsal Thalamus
(2007) · Springer eBooks · doi:10.1007/978-3-540-34686-9_8 · Cited by 1
Speculations about the Future
Mazziotta, J. C., & Toga, A. W. (2002) · Elsevier eBooks · doi:10.1016/b978-012693019-1/50033-2 · Cited by 2
The Computational Neuroanatomy of Predictive Dynamics of Pain PerceptionPreprint
Ishikawa, R., & Izawa, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.13.488260 · Cited by 2
Accurate spatial localization of Allen Human Brain Atlas gene expression data for human neuroimagingPreprint
Yee, Y., Liu, Y., French, L., Liu, V. M., Taha, A., Karat, B., Khan, A. R., Lau, J. C., Zeighami, Y., Devenyi, G. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.02.656812 · Cited by 3
“We relied on the core-matrix frame-1149 work 22 that describes a spatially varying distribution of parvalbumin ( PVALB )-expressing “core” neurons and calbindin ( CALB1 )-expressing “matrix” neurons.”
Influential
Multimodal functional imaging and clinical correlates of pain regions in chronic low-back pain patients treated with spinal cord stimulation: a pilot study
Oghli, Y. S., Ashok, A. B., Glener, S. R., Ailes, I., Syed, M., Kang, K. C., Naghizadehkashani, S., Fayed, I., Mohamed, F. B., Talekar, K. S., et al. (2024) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2024.1474060 · Cited by 1
“The VPL thalamus plays a role in providing ascending sensory information from the body to S1, including the dorsal column medial lemniscus (light touch and proprioception) and spinothalamic tract (nociception and temperature) (Jones, 1998).”
Background
Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss
Zhao, Y., Bizup, B. T., & Tzounopoulos, T. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2394-24.2025 · Cited by 1
Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats
Duarte, J. M., Janz, P., Bruns, A., Gross, S., Bainier, M., Debilly, S., Schöppenthau, S., Bielser, T., Künnecke, B., Schulz, J. M., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03537-z · Cited by 1
“Considering that AAV ef ﬁ cacy between sexes in mice has been documented in the literature to be different [73, 74], our ﬁ ndings should not be generalized to female rats.”
Diencefalo: talamo dorsale
Nieuwenhuys, R., Voogd, J., van Huijzen, C., & Papa, M. (2010) · Springer eBooks · doi:10.1007/978-88-470-1140-3_8 · Cited by 1
Calcium-Binding Proteins in Pretectum of Turtles (Immunohistochemical Study)
Belekhova, M. G., Kenigfest, N. B., & Mn, M. (2004) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1023/b:joey.0000033814.61527.ef · Cited by 1
“Calcium-binding proteins (CaBPr) are most important regulators of calcium balance in neurons and are used in comparative studies on representatives of different vertebrate species to elucidate the existence of phylogenetic succession (homology) in evolution of various brain structures and systems [2, 3].”
Background
Calcium-binding proteins and cytochrome oxidase activity in the turtle optic tectum with special reference to the tectofugal visual pathway
Belekhova, M. G., Chudinova, T. V., & Kenigfest, N. B. (2013) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093013050083 · Cited by 1
Homologous thalamic nuclei of the tectofugal visual system of reptiles and birds have different immunoreactivities towards calcium-binding proteins
Belekhova, M. G., Kenigfest, N. B., Chudinova, T. V., & Vesselkin, N. P. (2012) · Doklady Biological Sciences · doi:10.1134/s0012496612040059 · Cited by 1
Distinction in the immunoreactivities of two calcium‐binding proteins and neuronal birthdates in the first and higher‐order somatosensory thalamic nuclei of mice: Evolutionary implications
Zhang, J., Lin, Y., Gao, Y., Chao‐Xi, Zhang, X., Zhang, X., & Zeng, S. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23813 · Cited by 1
“…thalamic relay regions for auditory (the medial geniculate body), somatosensory (the ventral posterior complex and its environs), and visual (the dorsal lateral geniculate nucleus) inputs consist of a core region and adjacent diffuse areas (Jones, 1998; Durand et al., 1992; Zeng et al., 2004).”
Influential
Real-time tomography from magnetoencephalography (MEG)? experimental and theoretical challenges, possible physiological basis and evidence from the analysis of real data
Ioannides, A. A., & Kostopoulos, G. (2008) · Cited by 1
Pulvinar Structure, Circuitry & Function in Primates☆
Shipp, S. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04740-1 · Cited by 1
Neurons of visual thalamic nuclei projecting to telencephalon express different types of calcium-binding proteins: A combined immunocytochemical and tracer study
Kenigfest, N. B., & Belekhova, M. G. (2015) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093015060083 · Cited by 1
“Moreover, even in monkeys and humans in the lemniscal regions of sensory centers there is an overlap of dominant neurons expressing PV with less numerous CBand CR-ir neurons [17, 23].”
Background
Thalamus
Morel, A. (2007) · CRC Press eBooks · doi:10.3109/9781420016796-6 · Cited by 1
Distribution of calcium-binding proteins parvalbumin and calbindin in the pigeon telencephalic auditory center
Kenigfest, N. B., Belekhova, M. G., & Chudinova, T. V. (2017) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s1234567817020070 · Cited by 1
Calcium-Binding Proteins and Cytochrome Oxidase Activity in the Pigeon Entopallium: A Comparative Analysis of Interspecies Variability as Related to the Discussion on Avian Entopallium Homology
Belekhova, M. G., Vasilev, D. S., Kenigfest, N. B., & Chudinova, T. V. (2018) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093018010088 · Cited by 1
First and Higher Order Thalamic Relays
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0006 · Cited by 1
Glutamatergic Drivers and Modulators
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0005 · Cited by 1
Computational Modeling of Basic Cognitive Functionalities
(2023) · Cambridge University Press eBooks · doi:10.1017/9781108755610.014 · Cited by 1
Computational Neuroscience Models of Working Memory
Hazy, T. E., Frank, M. J., & O’Reilly, R. C. (2023) · Cambridge University Press eBooks · doi:10.1017/9781108755610.023 · Cited by 1
Axon terminal distribution in layer 1 of the mouse auditory cortex: differential projections from the dorsal and medial subdivisions of the medial geniculate body and the marginal zone of the posterior thalamic nuclei
Sun, M., Takemoto, M., Tomioka, R., Dong, C., Lin, A., & Song, W. (2025) · Hearing Research · doi:10.1016/j.heares.2025.109275 · Cited by 1
The Involvement of the Brainstem Reticular Formation in Pain Processing
Desbois, C., Monconduit, L., & Villanueva, L. (2001) · Springer eBooks · doi:10.1007/978-88-470-2258-4_4 · Cited by 1
Conceptual Approach to Human Death on Neurological Grounds
Machado, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-38977-6_3 · Cited by 1
Characteristics of the Structural Organization of the Ventral Posteromedial and Posterolateral Nuclei and the Reticular Nucleus of the Thalamus in Rats (an immunohistochemical study)
Kirichenko, E. Y., Мационис, А. Э., Повилайтите, П. Е., Akimenko, M. A., & Logvinov, A. K. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0444-9 · Cited by 1
Evolution of Thalamic Sensory Centers in Amniotes: Phylogeny and Functional Adaptation
Belekhova, M. G., & Kenigfest, N. B. (2018) · InTech eBooks · doi:10.5772/intechopen.73650 · Cited by 1
Overview of the Human Brain and Spinal Cord
ten Donkelaar, H. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-41878-6_1 · Cited by 1
Cell Types in the Thalamus and Cortex
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0002 · Cited by 1
MEG as an Enabling Tool in Neuroscience: Transcending Boundaries with New Analysis Methods and Devices
Hämäläinen, M., & Lundqvist, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-62657-4_81-1 · Cited by 1
Neuroactive steroids and rat CNS
Birzniece, V. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Global Neurodynamics and Deep Brain Stimulation
Pincus, D. I. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-0-306-48526-8_22 · Cited by 1
Structural-Metabolic Organization of Field 4 of the Cat Brain in Normal Conditions and after Unilateral Enucleation of the Eye
Александрович, З. П. (2004) · Neuroscience and Behavioral Physiology · doi:10.1023/b:neab.0000049649.64932.49 · Cited by 1
“A characteristic feature of the terminal of the projection of this nucleus to field 4 is its strict relationship with sublayer IIIb, while projections from the other thalamic nuclei are more diffusely seeded into layers III, V, and VI [11, 12].”
Background
Conditional activation of NRG1 signaling in the brain modulates cortical circuitry
Unterbarnscheidt, T. (2015) · doi:10.53846/goediss-5394
Global neurodynamics and deep brain stimulation: appreciating the perspectives of place and process.
Pincus, D. I. (2004) · PubMed · Cited by 1
Coupling and stochasticity in mesoscopic brain dynamics
Jedynak, M. (2017) · doi:10.5821/dissertation-2117-105831 · Cited by 1
Biomimetic model of corticostriatal micro-assemblies discovers new neural codePreprint
Pathak, A., Brincat, S. L., Organtzidis, H., Strey, H. H., Senneff, S., Antzoulatos, E. G., Mujica-Parodi, L. R., Miller, E. K., & Granger, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.06.565902 · Cited by 1
Thalamic Influence Over Adaptive Cortical Dynamics Across Conscious StatesPreprint
Müller, E. J., Munn, B., Baracchini, G., Fulcher, B., Medel, V., Redinbaugh, M. J., Saalmann, Y. B., Brunton, B. W., Brunton, S. L., & Shine, J. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.02.601788 · Cited by 1
A Theory of Thalamocortical Loops in Evidence Accumulation and Decision-MakingPreprint
Berry, M. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.23.696263 · Cited by 1
“Core-type relay cells are parvalbumin positive and project strongly and focally into layers 4 and 3 of the neocortex (Jones, 1998).”
Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturationPreprint
John, A., Saberi, A., Manoli, A., Royer, J., Erigüç, D. Y., Sydnor, V. J., Wan, B., Eickhoff, S. B., Bernhardt, B. C., Anwander, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.03.736332 · Cited by 1
“The high proportion of diffusely projecting matrix cells in nuclei VA, Vla and MD may help to explain the prolonged maturation of their connections, as matrix cell projections preferentially target cortical layer I-III and are more involved in higher cognitive processes (Müller et al., 2023, 2020).”
Course 13 Of the evolution of the brain
Treves, A., & Roudi, Y. (2005) · Les Houches/Les Houches · doi:10.1016/s0924-8099(05)80019-8
Modelação de fenômenos de plasticidade rápida no sistema visual de mamíferos
Oliveira, R. F. (2006) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2006.tde-31012007-113334
The pain of neuroinflammation
Deumens, R. (2010) · Digital Access to Libraries
Vegetative and Minimally Conscious States and Other Disturbances of Consciousness
Machado, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-38977-6_7
Functional neuroimaging of dual task interference and divided attention
Herath, P. (2002) · Figshare
NeuralCorrelatesofTactileDetection:ACombined MagnetoencephalographyandBiophysicallyBased ComputationalModelingStudy
Jones, S., & Pritchett, D. L. (2007)
Cytoarchitecture of the Anterior Cingulate Cortex in Patients with Schizophrenia, Bipolar Disorder and Major Depression
Abbass, M. (2014) · TSpace (University of Toronto)
reticulothalamic pathway Functional topographic organization of the motor
Sherman, S. M. (2015)
The intrinsic and synaptic properties of inverted pyramidal cells within the neocortex
Steger, R. (2015) · CUNY Academic Works (City University of New York)
Orthodontic tooth movement is associated with orofacial mechanical and thermal hypersensitivities and face sensorimotor cortex neuroplasticity
Sood, M. (2014) · TSpace (University of Toronto)
High-Throughput Analysis of Age-Dependent Protein Changes in Layer II/III of the Human Orbitofrontal Cortex
Kapadia, F. (2016) · TSpace (University of Toronto)
The slow oscillation as an intrinsic and emergent property of the neocortex
Lemieux, M. (2014) · Corpus Université Laval (Université Laval)
Experimental Histological Evidence of the Safety of Transcranial Direct Current Stimulation as a Therapeutic Procedure
Olubunmi, O. P. (2018) · American Journal of Psychiatry and Neuroscience · doi:10.11648/j.ajpn.20180603.15
Different Neurochemical Properties of Central and Peripheral Sensory Centers of Reptile Brain May Be a Cue to Their Evolution
Belekhova, M. G., Kenigfest, N. B., & Vesselkin, N. P. (2001) · Doklady Biological Sciences · doi:10.1023/a:1019261708451
Chronic Neurovascular Dysfunction in a Preclinical Model of Repeated Mild Traumatic Brain Injury
Adams, C. (2018) · TSpace (University of Toronto)
Distribution of Calcium-Binding Proteins and Cytochrome Oxidase Activity in the Projective Zone (Wulst) of the Pigeon Thalamofugal Visual Pathway: A Discussion in the Light of Current Concepts on Homology between the Avian Wulst and the Mammalian Striate (Visual) Cortex
Belekhova, M. G., Kenigfest, N. B., Vasilyev, D. S., & Chudinova, T. V. (2019) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093019040070
PECULIARITIES OF THE STRUCTURAL ORGANIZATION OF VENTRAL POSTEROMEDIAL, VENTRAL POSTEROLATERAL, AND RETICULAR NUCLEI OF RAT THALAMUS (AN IMMUNOHISTOCHEMICAL STUDY)
Kirichenko, Y. Y., Мационис, А. Э., Povilaityte, P. E., Akimenko, M. A., & Logvinov, A. K. (2016) · Morphology · doi:10.17816/morph.397731
Subthalamic Fiber Tracts
Morel, A. (2007) · CRC Press eBooks · doi:10.3109/9781420016796-8
Corticothalamic Circuits Linking Sensation and Action
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0013
Thalamic Circuitry
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0007
Classification of Thalamocortical and Corticothalamic Motifs
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0009
Intrinsic Membrane Properties
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0003
Brief Overview of Cortical Organization
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0008
Parallel Processing of Sensory Signals to Cortex
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0011
Thalamocortical Substrates of Attention
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0012
Synaptic Properties
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0004
Introduction
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0001
Conclusions
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.003.0014
Dynamic causal modeling of neural responses to an orofacial pneumotactile velocity array
Wang, Y., Custead, R., Oh, H., & Barlow, S. M. (2022) · Neuroimage Reports · doi:10.1016/j.ynirp.2022.100081 · Cited by 1
“…thalamocortical inputs to SII bypassing SI (Rowe et al., 1996; Turman et al., 1992; Zhang et al., 1996, 2001) and direct projections from thalamic nuclei (i.e., the ventral posterior nucleus, the ventral posterior inferior nucleus, etc.) to both SI and SII (Jones, 1998; Krubitzer and Kaas, 1992).”
Bibliography
(2001) · Elsevier eBooks · doi:10.1016/b978-012305460-9/50025-3
Faculty Opinions recommendation of Preferential effect of isoflurane on top-down vs. bottom-up pathways in sensory cortex.
Mashour, G. A. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.723876467.793500207
A blueprint of the developing mind
Turk, E. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/627
A phylogenetically-conserved axis of thalamocortical connectivity in the human brainPreprint
Oldham, S., & Ball, G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516574
Usefulness of Transcranial Motor Evoked Potential in Clipping Surgery for Cerebral Aneurysms-Introduction of a New Protocol for Stable Monitoring
SASAKI, T., Murakami, K., SAITO, A., Haryu, S., Kameyama, M., Takahashi, Y., TAKAMURO, S., Nana, K. A. T. O., & Toshiki, E. N. D. O. (2023) · Neurologia medico-chirurgica · doi:10.2176/jns-nmc.2023-0007
The Diversity and Synaptic Connectivity of Somatostatin-Containing Inhibitory Interneurons in the Somatosensory (Barrel) Cortex
Hostetler, R. E. (2023) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12253
Brain-consistent architecture for imagination
Yamakawa, H., Fukawa, A., Yairi, I. E., & Matsuo, Y. (2024) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2024.1302429
“• Modulation of neocortical layer activity and inter-area routing: Matrix relay cells in the thalamus project to the ﬁrst layer of the neocortex (Jones, 1998; Rodriguez et al., 2004; Bonjean et al., 2012; Kaneko, 2013; Harris and Shepherd, 2015; Wei et al., 2016), a feature that renders them…”
Background
The Diencephalon
Chakravarthi, S. S., Monroy-Sosa, A., & Elisevich, K. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822404-5.00013-9
Dedication
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.002.0004
Preface
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.002.0006
Copyright Page
Usrey, W. M., & Sherman, S. M. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780197503874.002.0003
Inferring the functional architecture of mammalian brains
Cisek, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00037-3
Evolution of neuronal cell types in vertebrate brains
Gattoni, G., Gurrola, A. O., Chua, N. J., & Tosches, M. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00071-3
T-Type Calcium Channels in Pain Neuronal Circuits
François, A., Pizzoccaro, A., Laffray, S., & Bourinet, E. (2013) · Springer eBooks · doi:10.1007/978-3-642-40282-1_6
Intégration multisensorielle et motrice chez le primate non humain : approches anatomique, comportementale et électrophysiologique
Cappe, C. (2007) · HAL
Conséquences de la délétion conditionnelle du gène Tshz3 dans la circuiterie cortico-striée : implications dans les troubles du spectre autistique
Chabbert, D. (2017) · theses.fr (ABES) · doi:10.70675/6ac224e2z22c7z4bd4zb6dazc3f301e5b758
Role of the thalamic nucleus reuniens in the cortico-hippocampal coupling and memory consolidation
Ferraris, M. (2020) · theses.fr (ABES) · doi:10.70675/3f54f650z6692z45e7z89dfz4cd46a512b83
Functional Neuro-Imaging Study of Deep Brain Stimulation Mechanisms for the Restoration of Consciousness Using a Non-Human Primate Mode
Tasserie, J. (2020) · theses.fr (ABES) · doi:10.70675/de1896a4z56b3z4f72z93dfz02c239bd29f1
Anatomie et physiologie des voies de sortie du cervelet chez le rongeur
Aïssa, H. B. (2021) · theses.fr (ABES) · doi:10.70675/892f74c0z4e20z49ddza717zda13327fd474
Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesiaPreprint
Pathak, A., Brincat, S. L., Xiong, Y., Organtzidis, H., Protter, M., Du, V., Strey, H. H., Mujica-Parodi, L. R., Miller, E. K., & Granger, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.10.731411
“…circuit is thus organized into modules that are anatomically and functionally modular (14, 25–36 , 44– Matrix thalamic nuclei, in contrast to the core loop, project to cortical layer I, diffusely contacting synapses on apical dendrites of layer II/III and of layer V cells (14, 26, 43, 47–49).”
Projectomic profiles of calbindin D28K-expressing neurons in the mediodorsal thalamic nucleus of mouse
Zhao, T.-Y., Zhu, H., Zhang, Y., Ren, X., Ye, X.-N., Li, F., Lei, L.-J., Zhang, M., Li, Y., & Zhang, F. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112013 · Cited by 1
Single-cell reconstruction of whole-brain efferent projections from mouse ventral posteromedial thalamus
Wei, H.-Z., Li, Y.-Y., Jia, H.-Y., Zhao, T.-Y., Ren, X., Qiu, X.-T., Zhang, F.-X., Li, Y.-Q., & Zhang, M.-M. (2026) · Brain Informatics · doi:10.1186/s40708-026-00315-z · Cited by 1
“…the classification of vlVPM VGluT2 neurons into two major clusters—those primarily innervating sensory cortices (Cluster 1) and those projecting to both sensory and motor/basal ganglia structures (Cluster 2)—parallels the classic “core-matrix” organization proposed for thalamic nuclei [27–29].”
Non-uniform structural development across human thalamus aligns with risk zones for schizophrenia in adulthoodPreprint
Singleton, O., & Gomez, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.29.735354
Conserved and specialized features of thalamocortical wiring revealed by single-cell projection mapping in mouse and marmosetPreprint
Fan, A. Y., Scott, J. T., Kuehn, N. M., Majeed, M., Cheng, S. Y., Qi, H., Summers, M. T., Hover, J., Johnson, T., Ouellette, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.07.736957 · Cited by 2
Consciousness Requires Four Neural Loops: Architecture, Mechanism, and NecessityPreprint
Stewart, A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6908698
Cortico-subcortical multi-head self-attention as a substrate for cognitive performancePreprint
Babu, V. K., Granier, A., Proix, T., Balvočius, T., Woodman, M., Saudargienė, A., Jirsa, V., & Senn, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.06.743205 · Cited by 1
Spectrotemporal signatures of driving- and modulatory circuits across cortical and subcortical networks
O’Connell, M. N., Barczak, A., Mackey, C. A., McGinnis, T., Mackin, K., Smiley, J. F., Bleiwas, C., Lakatos, P. A., & Schroeder, C. E. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1868940
“Similarly, cortical sensory areas integrate both bottom-up driving and modulatory inputs (Jones, 1998, 2001), and top-down modulatory influences that shape oscillatory dynamics (Gilbert and Li, 2013; Helfrich and Knight, 2016).”
Neural selection in corticothalamocortical loops: Heterogeneity as a computational resource
Munn, B., Müller, E. J., Whyte, C. J., Brouwer, T., John, Y. J., Aru, J., Mototaka Suzuki, A., Saalmann, Y. B., Larkum, M. E., & Shine, J. M. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102945 · Cited by 1
Cortico-striato-pallido-thalamic loop: Effects of age on white matter neurite microstructural properties and its spatial gradientsPreprint
Pongpipat, E. E., Kennedy, K. M., & Rodrigue, K. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.19.745815

Authors: Jones, E. G.
Affiliations: University of California, Irvine (US)
Corresponding author: Jones, E.G
ORCID: Jones, E.G
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1998-04
Volume: 85
Issue: 2
Pages: 331-345
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(97)00581-2
OpenAlex: W2054508155
Cited by: 504
References: 73
Citations by year: 2026: 15 · 2025: 21 · 2024: 23 · 2023: 25 · 2022: 13 · 2021: 38 · 2020: 23 · 2019: 24 · 2018: 19 · 2017: 21 · 2016: 17 · 2015: 23 · 2014: 20 · 2013: 10 · 2012: 14
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns022317-08)
National Institute of Neurological Disorders and Stroke (NS-22317, NS21377, R01NS021377)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: thalamus, thalamocortical connections, intralaminar nuclei, calbindin, parvalbumin, calcium-binding proteins, cortical layers, corticothalamic connections, consciousness, primates
MeSH terms: Animals, Cerebral Cortex, Humans, Neural Pathways, Neurons, Thalamus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Viewpoint: the core and matrix of thalamic organization

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks