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Cited by 504Neural dynamics and brain functionVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Viewpoint: the core and matrix of thalamic organization

Jones, E.G·1998·Neuroscience
DOI 10.1016/s0306-4522(97)00581-2
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Abstract

The integration of the whole cerebral cortex and thalamus during forebrain activities that underlie different states of consciousness, requires pathways for the dispersion of thalamic activity across many cortical areas. Past theories have relied on the intralaminar nuclei as the sources of diffuse thalamocortical projections that could facilitate spread of activity across the cortex. A case is made for the presence of a matrix of superficially-projecting cells, not confined to the intralaminar nuclei but extending throughout the whole thalamus. These cells are distinguished by immunoreactivity for the calcium-binding protein, D28K calbindin, are found in all thalamic nuclei of primates and have increased numbers in some nuclei. They project to superficial layers of the cerebral cortex over relatively wide areas, unconstrained by architectonic boundaries. They generally receive subcortical inputs that lack the topographic order and physiological precision of the principal sensory pathways. Superimposed upon the matrix in certain nuclei only, is a core of cells distinguished by immunoreactivity for another calcium-binding protein, parvalbumin, These project in highly ordered fashion to middle layers of the cortex in an area-specific manner. They are innervated by subcortical inputs that are topographically precise and have readily identifiable physiological properties. The parvalbumin cells form the basis for sensory and other inputs that are to be used as a basis for perception. The calbindin cells, especially when recruited by corticothalamic connections, can form a basis for the engagement of multiple cortical areas and thalamic nuclei that is essential for the binding of multiple aspects of sensory experience into a single framework of consciousness.

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Citations

Cites

Research works printed but not linked: 7

  1. Hunt, 1988, The exact distribution of striatally-projecting thalamic neurons in the monkey, Neurosci. Abstr., 14, 188
  2. Jasper H. H. (1960) Unspecific thalamocortical relations. In Handbook of Physiology Section 1, Neurophysiology (eds Field J., Magoun H. W. and Hall V. E.), Vol. 2, pp. 1307–1321. Washington, DC, U.S.A.
  3. Jones E. G. (1988) Modern views of cellular thalamic mechanisms. In Cellular Thalamic Mechanisms (eds Bentivoglio M. and Spreafico R.), pp. 1–22. Elsevier, Amsterdam.
  4. Jones E. G. (1989) Defining the thalamic intralaminar nuclei in primates. In Neurologia e Scienze Base. Scritti in Onore di Giorgio Macchi (eds Gainotti G., Bentivoglio M., Bergonzi P. and Ferro F. M.), pp. 161–194. Università Cattolica del Sacre Cuore, Milan.
  5. Lorente de Nó R. (1938) Cerebral cortex: architectonics, intracortical connections. In Physiology of the Nervous System (ed Fulton J. R.), pp. 274–301. Oxford, New York.
  6. Steriade M., Jones E. G. and Llinás R. R. (1990) Thalamic Oscillations and Signalling. Wiley, New York.
  7. Steriade M., Jones E. G. and McCormick D. A. (1997) Thalamus. Elsevier, Oxford.

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Metadata

Authors
Jones, E. G.
Affiliations
University of California, Irvine (US)
Corresponding author
Jones, E.G
ORCID
Jones, E.G
Venue
Neuroscience
Publisher
Elsevier BV
Published
1998-04
Volume
85
Issue
2
Pages
331-345
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(97)00581-2
OpenAlex
W2054508155
Cited by
504
References
73
Citations by year
2026: 15 · 2025: 21 · 2024: 23 · 2023: 25 · 2022: 13 · 2021: 38 · 2020: 23 · 2019: 24 · 2018: 19 · 2017: 21 · 2016: 17 · 2015: 23 · 2014: 20 · 2013: 10 · 2012: 14
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns022317-08)
  • National Institute of Neurological Disorders and Stroke (NS-22317, NS21377, R01NS021377)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
thalamus, thalamocortical connections, intralaminar nuclei, calbindin, parvalbumin, calcium-binding proteins, cortical layers, corticothalamic connections, consciousness, primates
MeSH terms
Animals, Cerebral Cortex, Humans, Neural Pathways, Neurons, Thalamus

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