Cited by 961Multisensory perception and integrationNeural dynamics and brain functionNeuroscience and Music Perception

Neuronal oscillations and multisensory interaction in primary auditory cortex

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Lakatos, Peter, Chen, Chi-Ming, O'Connell, Monica N., Mills, Aimee, Schroeder, Charles E.·2007·Neuron

Abstract

Recent anatomical, physiological, and neuroimaging findings indicate multisensory convergence at early, putatively unisensory stages of cortical processing. The objective of this study was to confirm somatosensory-auditory interaction in A1 and to define both its physiological mechanisms and its consequences for auditory information processing. Laminar current source density and multiunit activity sampled during multielectrode penetrations of primary auditory area A1 in awake macaques revealed clear somatosensory-auditory interactions, with a novel mechanism: somatosensory inputs appear to reset the phase of ongoing neuronal oscillations, so that accompanying auditory inputs arrive during an ideal, high-excitability phase, and produce amplified neuronal responses. In contrast, responses to auditory inputs arriving during the opposing low-excitability phase tend to be suppressed. Our findings underscore the instrumental role of neuronal oscillations in cortical operations. The timing and laminar profile of the multisensory interactions in A1 indicate that nonspecific thalamic systems may play a key role in the effect.

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Crossref · 10.1016/j.neuron.2006.12.011

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  • Phase reset and synchronization of ongoing oscillatory activity may be impacted in autism spectrum disorder.

    “One hypothesized mechanism for this information transfer across broad regions is the phase reset and synchronization of ongoing oscillatory activity (Diederich et al., 2012; Fries, 2005; Lakatos et al., 2007; Mercier et al., 2013; Varela et al., 2001), which may be impacted in ASD (Buard et al., 2013; Khan et al., 2013; Milne et al., 2009).”

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Authors
Lakatos, P., Chen, C.-M., O'Connell, M. N., Mills, A., & Schroeder, C. E.
Affiliations
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Schroeder, Charles E.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-01
Volume
53
Issue
2
Pages
279-292
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2146037001
Cited by
961
References
61
Citations by year
2026: 19 · 2025: 23 · 2024: 30 · 2023: 39 · 2022: 35 · 2021: 38 · 2020: 50 · 2019: 58 · 2018: 47 · 2017: 52 · 2016: 46 · 2015: 68 · 2014: 63 · 2013: 59 · 2012: 63
FWCI
89.43
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH61989, R01MH061989)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords
primary auditory cortex, multisensory interaction, neural oscillations, current source density, multi-unit activity, phase resetting, cortical excitability, thalamocortical system, multisensory convergence
MeSH terms
Afferent Pathways, Animals, Auditory Cortex, Electrophysiology, Macaca, Male, Neurons, Oscillometry, Sensation, Somatosensory Cortex, Time Factors

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