Neuronal oscillations and multisensory interaction in primary auditory cortex
Open accessAbstract
Recent anatomical, physiological, and neuroimaging findings indicate multisensory convergence at early, putatively unisensory stages of cortical processing. The objective of this study was to confirm somatosensory-auditory interaction in A1 and to define both its physiological mechanisms and its consequences for auditory information processing. Laminar current source density and multiunit activity sampled during multielectrode penetrations of primary auditory area A1 in awake macaques revealed clear somatosensory-auditory interactions, with a novel mechanism: somatosensory inputs appear to reset the phase of ongoing neuronal oscillations, so that accompanying auditory inputs arrive during an ideal, high-excitability phase, and produce amplified neuronal responses. In contrast, responses to auditory inputs arriving during the opposing low-excitability phase tend to be suppressed. Our findings underscore the instrumental role of neuronal oscillations in cortical operations. The timing and laminar profile of the multisensory interactions in A1 indicate that nonspecific thalamic systems may play a key role in the effect.
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Phase reset and synchronization of ongoing oscillatory activity may be impacted in autism spectrum disorder.
“One hypothesized mechanism for this information transfer across broad regions is the phase reset and synchronization of ongoing oscillatory activity (Diederich et al., 2012; Fries, 2005; Lakatos et al., 2007; Mercier et al., 2013; Varela et al., 2001), which may be impacted in ASD (Buard et al., 2013; Khan et al., 2013; Milne et al., 2009).”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Lakatos et al., 2007
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Saccadic reaction times to audiovisual stimuli show effects of oscillatory phase reset
Diederich, A., Schomburg, A., & Colonius, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044910 · Cited by 27 · see citing works
- Authors
- Lakatos, P., Chen, C.-M., O'Connell, M. N., Mills, A., & Schroeder, C. E.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Schroeder, Charles E.
- ORCID
- Chen, Chi-Ming
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 53
- Issue
- 2
- Pages
- 279-292
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3717319
- OpenAlex
- W2146037001
- Cited by
- 961
- References
- 61
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 30 · 2023: 39 · 2022: 35 · 2021: 38 · 2020: 50 · 2019: 58 · 2018: 47 · 2017: 52 · 2016: 46 · 2015: 68 · 2014: 63 · 2013: 59 · 2012: 63
- FWCI
- 89.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH61989, R01MH061989)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- primary auditory cortex, multisensory interaction, neural oscillations, current source density, multi-unit activity, phase resetting, cortical excitability, thalamocortical system, multisensory convergence
- MeSH terms
- Afferent Pathways, Animals, Auditory Cortex, Electrophysiology, Macaca, Male, Neurons, Oscillometry, Sensation, Somatosensory Cortex, Time Factors
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