Control of Spatiotemporal Coherence of a Thalamic Oscillation by Corticothalamic Feedback
Abstract
The mammalian thalamus is the gateway to the cortex for most sensory modalities. Nearly all thalamic nuclei also receive massive feedback projections from the cortical region to which they project. In this study, the spatiotemporal properties of synchronized thalamic spindle oscillations (7 to 14 hertz) were investigated in barbiturate-anesthetized cats, before and after removal of the cortex. After complete ipsilateral decortication, the long-range synchronization of thalamic spindles in the intact cortex hemisphere changed into disorganized patterns with low spatiotemporal coherence. Local thalamic synchrony was still present, as demonstrated by dual intracellular recordings from nearby neurons. In the cortex, synchrony was insensitive to the disruption of horizontal intracortical connections. These results indicate that the global coherence of thalamic oscillations is determined by corticothalamic projections.
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Corticothalamic connections play a prominent role in synchronizing oscillations, and the thalamus modulates phase relationships between cortical regions, thereby modulating effective synaptic strengths.
“Corticothalamic connections play a prominent role in synchronizing oscillations [65], and the thalamus modulates phase relationships between cortical regions, thereby modulating the effective synaptic strengths.”
From Cerebral hierarchies: predictive processing, precision and the pulvinar (2015) · cites this paper as [65]
Cites
Numerical Recipes, The Art of Scientific Computing
Press, W. H., Flannery, B. P., Teukolsky, S. A., Vetterling, W. T., & Gould, H. (1987) · American Journal of Physics · doi:10.1119/1.14981 · Cited by 10,032 · see citing works
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564 · see citing works
Self-citationJones, E. G. (1985) · Springer eBooks · doi:10.1007/978-1-4615-1749-8 · Cited by 1,164 · see citing works
Cellular Mechanisms of a Synchronized Oscillation in the Thalamus
von Krosigk, M., Bal, T., & McCormick, D. A. (1993) · Science · doi:10.1126/science.8392750 · Cited by 837 · see citing works
Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
Contreras, D., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00604.1995 · Cited by 700 · see citing works
Self-citationPhysiological basis of the alpha rhythm
Purpura, D. P. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90182-5 · Cited by 599 · see citing works
Sillito, A. M., Jones, H. E., Gerstein, G. L., & West, D. C. (1994) · Nature · doi:10.1038/369479a0 · Cited by 554 · see citing works
Physiological Basis of the Alpha Rhythm
Andersen, P. N., & Andersson, S. A. (1968) · Medical Entomology and Zoology · Cited by 540 · see citing works
Alain Destexhe, A., Bal, T., McCormick, D. A., & B, T. J. S. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.2049 · Cited by 418 · see citing works
Thalamic oscillations and signaling.
Steriade, M., Jones, E. G., & Llinás, R. R. (1990) · Medical Entomology and Zoology · Cited by 350 · see citing works
Self-citationContreras, D., & Steriade, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021133 · Cited by 329 · see citing works
Self-citationBal, T., & McCormick, D. A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019794 · Cited by 319 · see citing works
Bal, T., von Krosigk, M., & McCormick, D. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020612 · Cited by 316 · see citing works
Steriade, M., Parent, A., & Hada, J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902290407 · Cited by 278 · see citing works
Self-citationMECHANISM OF THALAMOCORTICAL AUGMENTATION AND REPETITION
Morison, R. S., & Dempsey, E. W. (1943) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1943.138.2.297 · Cited by 237 · see citing works
ELECTRICAL ACTIVITY OF THE THALAMUS AND BASAL GANGLIA IN DECORTICATE CATS
Morison, R. S., & Bassett, D. L. (1945) · Journal of Neurophysiology · doi:10.1152/jn.1945.8.5.309 · Cited by 183 · see citing works
Corticothalamic projections and sensorimotor activities
Frigyesi, T. L., Rinvik, E., & Yahr, M. D. (1972) · Medical Entomology and Zoology · Cited by 111 · see citing works
The action of the corticofugal pathway on sensory thalamic nuclei: A hypothesis
Koch, C. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90064-9 · Cited by 110 · see citing works
Nicolelis, M. A. L., Lin, R. C., Woodward, D. J., & Chapin, J. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2212 · Cited by 107 · see citing works
Avendaño, C., Rausell, E., Aguilar, D. P., & Isorna, S. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902780102 · Cited by 97 · see citing works
Modeling the control of reticular thalamic oscillations by neuromodulators
Alain Destexhe, A., Contreras, D., B, T. J. S. A., & Steriade, M. (1994) · Neuroreport · doi:10.1097/00001756-199411000-00003 · Cited by 93 · see citing works
Self-citationThalamic oscillations and signaling
Purpura, D. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90374-w · Cited by 59 · see citing works
Smith, R. J. (1985) · Science · doi:10.1126/science.229.4711.361 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works
Foxe, J. J., & Snyder, A. C. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00154 · Cited by 1,558 · see citing works
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296 · see citing works
Self-citationCoordinated interactions between hippocampal Ripples and Cortical Spindles during Slow-Wave Sleep
Siapas, A. G., & Wilson, M. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80629-7 · Cited by 1,052 · see citing works
Sleep spindles: mechanisms and functions
Fernandez, L. M. J., & Lüthi, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2018 · Cited by 716 · see citing works
The thalamic matrix and thalamocortical synchrony
Jones, E. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01922-6 · Cited by 688 · see citing works
Is perception discrete or continuous?
VanRullen, R., & Koch, C. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(03)00095-0 · Cited by 662 · see citing works
Viewpoint: the core and matrix of thalamic organization
Jones, E. G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00581-2 · Cited by 504 · see citing works
Wamsley, E. J., Tucker, M. A., Shinn, A. K., Ono, K. E., McKinley, S. K., Ely, A. V., Goff, D. C., Stickgold, R., & Manoach, D. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.008 · Cited by 492 · see citing works
Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings
Andrillon, T., Nir, Y., Staba, R. J., Ferrarelli, F., Cirelli, C., Tononi, G., & Fried, I. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2604-11.2011 · Cited by 504 · see citing works
Why do we sleep?11Published on the World Wide Web on 7 November 2000.
Sejnowski, T. J., & Destexhe, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03007-9 · Cited by 489 · see citing works
Self-citationCerebral hierarchies: predictive processing, precision and the pulvinar
Kanai, R., Komura, Y., Shipp, S., & Friston, K. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0169 · Cited by 432 · see citing works
Steriade, M. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.583 · Cited by 429 · see citing works
Self-citationThe Connectional Organization of the Cortico-thalamic System of the Cat
Scannell, J. W. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.3.277 · Cited by 371 · see citing works
Are corticothalamic ‘up’ states fragments of wakefulness?
Destexhe, A., Hughes, S. W., Rudolph, M., & Crunelli, V. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.04.006 · Cited by 355 · see citing works
Self-citationDynamical relaying can yield zero time lag neuronal synchrony despite long conduction delays
Vicente, R., Gollo, L. L., Mirasso, C. R., Fischer, I., & Pipa, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809353105 · Cited by 341 · see citing works
Thalamic circuitry and thalamocortical synchrony
Jones, E. G. (2002) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1168 · Cited by 340 · see citing works
Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
Schiff, N. D., Ribary, U., Moreno, D. R., Beattie, B., Kronberg, E., Blasberg, R., Giacino, J., McCagg, C., Fins, J. J., Llinás, R., et al. (2002) · Brain · doi:10.1093/brain/awf131 · Cited by 306 · see citing works
Interaction between neocortical and hippocampal networks via slow oscillations
Sirota, A., & Buzsáki, G. (2005) · Thalamus and Related Systems · doi:10.1017/s1472928807000258 · Cited by 270 · see citing works
A conserved switch in sensory processing prepares developing neocortex for vision
Colonnese, M. T., Kaminska, A., Minlebaev, M., Milh, M., Bloem, B., Lescure, S., Moriette, G., Chiron, C., Ben-Ari, Y., & Khazipov, R. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.015 · Cited by 273 · see citing works
Weliky, M., & Katz, L. C. (1999) · Science · doi:10.1126/science.285.5427.599 · Cited by 266 · see citing works
The reticular nucleus revisited: Intrinsic and network properties of a thalamic pacemaker
FUENTEALBA, P., & STERIADE, M. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.01.002 · Cited by 263 · see citing works
Self-citationSlow oscillations orchestrating fast oscillations and memory consolidation
Mölle, M., & Born, J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00007-7 · Cited by 270 · see citing works
Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations
DESTEXHE, A., & SEJNOWSKI, T. J. (2003) · Physiological Reviews · doi:10.1152/physrev.00012.2003 · Cited by 241 · see citing works
Form and function of sleep spindles across the lifespan
Clawson, B. C., Durkin, J., & Aton, S. J. (2016) · Neural Plasticity · doi:10.1155/2016/6936381 · Cited by 178 · see citing works
“Decortication leads to gross desynchrony of spindles across TC sites in vivo [28].”
BackgroundNREM and REM Sleep: Complementary Roles in Recovery after Wakefulness
Vyazovskiy, V. V., & Delogu, A. (2014) · The Neuroscientist · doi:10.1177/1073858413518152 · Cited by 169 · see citing works
Abnormal sleep spindles, memory consolidation, and schizophrenia
Manoach, D. S., & Stickgold, R. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095754 · Cited by 157 · see citing works
Parallel driving and modulatory pathways link the prefrontal cortex and thalamus
Zikopoulos, B., & Barbas, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000848 · Cited by 114 · see citing works
A mechanism for learning with sleep spindles
Peyrache, A., & Seibt, J. (2020) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2019.0230 · Cited by 89 · see citing works
Extrastriate feedback to primary visual cortex in primates: a quantitative analysis of connectivity
Budd, J. M. L. (1998) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1998.0396 · Cited by 99 · see citing works
Ayoub, A., Aumann, D., Hörschelmann, A., Kouchekmanesch, A., Paul, P., Born, J., & Marshall, L. (2013) · Sleep · doi:10.5665/sleep.2722 · Cited by 91 · see citing works
Temporal evolution of coherence and power in the human sleep electroencephalogram
Achermann, P., & BorbÉly, A. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.7.s1.6.x · Cited by 89 · see citing works
Yang, M., Logothetis, N. K., & Eschenko, O. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2107-18.2018 · Cited by 57 · see citing works
Spindle activity orchestrates plasticity during development and sleep
Lindemann, C., Ahlbeck, J., Bitzenhofer, S. H., & Hanganu-Opatz, I. L. (2016) · Neural Plasticity · doi:10.1155/2016/5787423 · Cited by 59 · see citing works
Thalamocortical Oscillations: Local Control of EEG Slow Waves
Timofeev, I., & Chauvette, S. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611797470376 · Cited by 55 · see citing works
Corticothalamic pathways from layer 5: emerging roles in computation and pathology
Mease, R. A., & Gonzalez, A. J. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.730211 · Cited by 36 · see citing works
Freitas da Rocha, A., Pereira, A., & Bezerra Coutinho, F. A. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00069-1 · Cited by 41 · see citing works
Out of thin air: hyperventilation-triggered seizures
Salvati, K. A., & Beenhakker, M. P. (2019) · Brain Research · doi:10.1016/j.brainres.2017.12.037 · Cited by 30 · see citing works
- Authors
- Contreras, D., Destexhe, A., Sejnowski, T. J., & Steriade, M.
- Affiliations
- Université Laval (CA)
- D. Contreras, A. Destexhe, M. Steriade, Laboratoire de Neurophysiologie, Faculté de Médecine, Université Laval, Quebec G1K 7P4, Canada.
- T. J. Sejnowski, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, and Department of Biology, University of California San Diego, La Jolla, CA 92093, USA.
- Corresponding author
- Steriade, Mircea
- ORCID
- Contreras, Diego
- Venue
- Science
- Published
- 1996-11
- Volume
- 274
- Issue
- 5288
- Pages
- 771-774
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093640201
- Cited by
- 515
- References
- 23
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 6 · 2023: 29 · 2022: 13 · 2021: 8 · 2020: 16 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 12 · 2014: 22 · 2013: 22 · 2012: 13
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Keywords
- corticothalamic feedback, spatiotemporal coherence, decortication, intracortical connections, thalamocortical connections, oscillation synchronization, cats
- MeSH terms
- Anesthesia, Animals, Cats, Cerebral Cortex, Cortical Synchronization, Electrophysiology, Feedback, Neural Pathways, Synaptic Transmission, Sleep, Thalamus
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