Cited by 515Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchNonlinear Dynamics and Pattern Formation

Control of Spatiotemporal Coherence of a Thalamic Oscillation by Corticothalamic Feedback

Contreras, Diego, Destexhe, Alain, Sejnowski, Terrence J., Steriade, Mircea·1996·Science

Abstract

The mammalian thalamus is the gateway to the cortex for most sensory modalities. Nearly all thalamic nuclei also receive massive feedback projections from the cortical region to which they project. In this study, the spatiotemporal properties of synchronized thalamic spindle oscillations (7 to 14 hertz) were investigated in barbiturate-anesthetized cats, before and after removal of the cortex. After complete ipsilateral decortication, the long-range synchronization of thalamic spindles in the intact cortex hemisphere changed into disorganized patterns with low spatiotemporal coherence. Local thalamic synchrony was still present, as demonstrated by dual intracellular recordings from nearby neurons. In the cortex, synchrony was insensitive to the disruption of horizontal intracortical connections. These results indicate that the global coherence of thalamic oscillations is determined by corticothalamic projections.

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Crossref · 10.1126/science.274.5288.771

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  • Corticothalamic connections play a prominent role in synchronizing oscillations, and the thalamus modulates phase relationships between cortical regions, thereby modulating effective synaptic strengths.

    “Corticothalamic connections play a prominent role in synchronizing oscillations [65], and the thalamus modulates phase relationships between cortical regions, thereby modulating the effective synaptic strengths.”

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Authors
Contreras, D., Destexhe, A., Sejnowski, T. J., & Steriade, M.
Affiliations
  • Université Laval (CA)
  • D. Contreras, A. Destexhe, M. Steriade, Laboratoire de Neurophysiologie, Faculté de Médecine, Université Laval, Quebec G1K 7P4, Canada.
  • T. J. Sejnowski, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, and Department of Biology, University of California San Diego, La Jolla, CA 92093, USA.
Corresponding author
Steriade, Mircea
Venue
Science
Published
1996-11
Volume
274
Issue
5288
Pages
771-774
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2093640201
Cited by
515
References
23
Citations by year
2026: 5 · 2025: 12 · 2024: 6 · 2023: 29 · 2022: 13 · 2021: 8 · 2020: 16 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 12 · 2014: 22 · 2013: 22 · 2012: 13
FWCI
13.56
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
Keywords
corticothalamic feedback, spatiotemporal coherence, decortication, intracortical connections, thalamocortical connections, oscillation synchronization, cats
MeSH terms
Anesthesia, Animals, Cats, Cerebral Cortex, Cortical Synchronization, Electrophysiology, Feedback, Neural Pathways, Synaptic Transmission, Sleep, Thalamus

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