Adaptive plasticity in vestibular influences on cardiovascular control
Abstract
Data collected in both human subjects and animal models indicate that the vestibular system influences the control of blood pressure. In animals, peripheral vestibular lesions diminish the capacity to rapidly and accurately make cardiovascular adjustments to changes in posture. Thus, one role of vestibulo-cardiovascular influences is to elicit changes in blood distribution in the body so that stable blood pressure is maintained during movement. However, deficits in correcting blood pressure following vestibular lesions diminish over time, and are less severe when non-labyrinthine sensory cues regarding body position in space are provided. These observations show that pathways that mediate vestibulo-sympathetic reflexes can be subject to plastic changes. This review considers the adaptive plasticity in cardiovascular responses elicited by the central vestibular system. Recent data indicate that the posterior cerebellar vermis may play an important role in adaptation of these responses, such that ablation of the posterior vermis impairs recovery of orthostatic tolerance following subsequent vestibular lesions. Furthermore, recent experiments suggest that non-labyrinthine inputs to the central vestibular system may be important in controlling blood pressure during movement, particularly following vestibular dysfunction. A number of sensory inputs appear to be integrated to produce cardiovascular adjustments during changes in posture. Although loss of any one of these inputs does not induce lability in blood pressure, it is likely that maximal blood pressure stability is achieved by the integration of a variety of sensory cues signaling body position in space.
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Vestibular activity powerfully influences respiration and heart rate.
“Other experiments by the Yates group have shown powerful influences of vestibular activity on respiration and heart rate (Yates et al. 2000).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Yates et al. 2000
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Motion sickness: more than nausea and vomiting
Lackner, J. R. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4008-8 · Cited by 314 · see citing works
“Other experiments by the Yates group have shown powerful influences of vestibular activity on respiration and heart rate (Yates et al. 2000).”
BackgroundLackner, J. R., & DiZio, P. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0697-y · Cited by 163 · see citing works
Role Of The Vestibular System In Regulating Respiratory Muscle Activity During Movement
Yates, B., Billig, I., Cotter, L., Mori, R., & Card, J. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03612.x · Cited by 54 · see citing works
Self-citation
- Authors
- Yates, B. J., Holmes, M. J., & Jian, B. J.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Yates, B.J
- ORCID
- Yates, B.J
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 53
- Issue
- 1
- Pages
- 3-9
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2036079335
- Cited by
- 59
- References
- 70
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (R01DC003732, R01 DC03732, R01DC000693, P01-DC03417, P01DC003417)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- adaptive plasticity, blood pressure regulation, vestibular lesions, orthostatic tolerance, sensory integration
- MeSH terms
- Afferent Pathways, Animals, Cardiovascular System, Cardiovascular Physiological Phenomena, Cerebellum, Denervation, Humans, Models, Neurological, Movement, Neuronal Plasticity, Posture, Rotation, Vestibular Nerve, Vestibular Nuclei, Recovery of Function
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