Space motion sickness

Lackner, James R.; DiZio, Paul

doi:10.1007/s00221-006-0697-y

Cited by 163Spaceflight effects on biologyVestibular and auditory disordersCardiovascular Syncope and Autonomic Disorders

Space motion sickness

Lackner, James R., DiZio, Paul·2006·Experimental Brain Research

DOI 10.1007/s00221-006-0697-y

Open this paper in CoChat — free account

Abstract

Motion sickness remains a persistent problem in spaceflight. The present review summarizes available knowledge concerning the incidence and onset of space motion sickness and aspects of the physiology of motion sickness. Proposed etiological factors in the elicitation of space motion sickness are evaluated including fluid shifts, head movements, visual orientation illusions, Coriolis cross-coupling stimulation, and otolith asymmetries. Current modes of treating space motion sickness are described. Theoretical models and proposed ground-based paradigms for understanding and studying space motion sickness are critically analyzed. Prediction tests and questionnaires for assessing susceptibility to space motion sickness and their limitations are discussed. We conclude that space motion sickness does represent a form of motion sickness and that it does not represent a unique diagnostic entity. Motion sickness arises when movements are made during exposure to unusual force backgrounds both higher and lower in magnitude than 1 g earth gravity.

Integrity signals

Registry

Crossref · 10.1007/s00221-006-0697-y

Cites

190 of 190 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

With incremental exposure, people can develop context specific adaptations so that they can move between a rotating artificial gravity environment and a stationary environment without either sensory motor control or motion sickness problems.
“With incremental exposure, people also can develop context specific adaptations so that, for example, they can move between a rotating artificial gravity environment and a stationary environment without either sensory motor control or motion sickness problems (Graybiel and Knepton 1978a, b; Lackner and DiZio 2000a, b, 2006).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Lackner and DiZio 2006

Aviat space environ med
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90318-p · Cited by 5,774 · see citing works
Mammalian Vestibular Physiology
Wilson, V. J., & Jones, G. M. (1979) · doi:10.1007/978-1-4757-5702-6 · Cited by 959 · see citing works
Principles of psychophysiology : physical, social, and inferential elements
Cacioppo, J. T., & Tassinary, L. G. (1990) · Cambridge University Press eBooks · Cited by 780 · see citing works
Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after‐nystagmus
Cohen, B., Matsuo, V., & Raphan, T. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011955 · Cited by 757 · see citing works
Handbook of Virtual Environments
(2002) · CRC Press eBooks · doi:10.1201/9780585399102 · Cited by 631 · see citing works
Motion sickness: a synthesis and evaluation of the sensory conflict theory
Oman, C. M. (1990) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y90-044 · Cited by 480 · see citing works
Clinical neurophysiology of the vestibular system
May, J. S. (1991) · Surgical Neurology · doi:10.1016/0090-3019(91)90083-l · Cited by 448 · see citing works
Untitled work
(1968) · PubMed · Cited by 428 · see citing works
Motion Sickness: An Evolutionary Hypothesis
Treisman, M. (1977) · Science · doi:10.1126/science.301659 · Cited by 393 · see citing works
Motion sickness.
Money, K. E. (1970) · Physiological Reviews · doi:10.1152/physrev.1970.50.1.1 · Cited by 392 · see citing works
The Area Postrema and Vomiting
Miller, A. D., & Leslie, R. A. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1012 · Cited by 375 · see citing works
Motion sickness: only one provocative conflict?
Bles, W., Bos, J. E., de Graaf, B., Groen, E., & Wertheim, A. H. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00115-4 · Cited by 335 · see citing works
A Heuristic Mathematical Model for the Dynamics of Sensory Conflict and Motion Sickness
Oman, C. M. (1982) · Acta Oto-Laryngologica · doi:10.3109/00016488209108197 · Cited by 329 · see citing works
Motion Sickness Incidence as a Function of the Frequency and Acceleration of Vertical Sinusoidal Motion
O'Hanlon, J. F., & McCauley, M. E. (1973) · doi:10.21236/ad0768215 · Cited by 318 · see citing works
Space Physiology and Medicine
Mirkin, D. B. (1994) · JAMA · doi:10.1001/jama.1994.03520050087038 · Cited by 281 · see citing works
Modelling motion sickness and subjective vertical mismatch detailed for vertical motions
Bos, J. E., & Bles, W. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00088-4 · Cited by 233 · see citing works
Physiological basis and pharmacology of motion sickness: an update
Yates, B. J., Miller, A. D., & Lucot, J. B. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00092-6 · Cited by 230 · see citing works
Defective ubiquitination of cerebral proteins in Alzheimer's disease
Salon, M. L., Morelli, L., Casta�o, E. M., Soto, E. F., & Pasquini, J. M. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 224 · see citing works
Spectral analysis of tachygastria recorded during motion sickness
Stern, R. M., Koch, K. L., Stewart, W. R., & Lindblad, I. M. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90843-2 · Cited by 218 · see citing works
The effects of gravitoinertial force level and head movements on post-rotational nystagmus and illusory after-rotation
DiZio, P. A., & Lackner, J. R. (1988) · Experimental Brain Research · doi:10.1007/bf00247597 · Cited by 176 · see citing works
Self-citation
Sopite syndrome: a sometimes sole manifestation of motion sickness.
Graybiel, A., & Knepton, J. C. (1976) · PubMed · Cited by 159 · see citing works
The influence of gravitoinertial force level on oculomotor and perceptual responses to Coriolis, cross-coupling stimulation.
DiZio, P. A., Lackner, J. R., & Evanoff, J. N. (1987) · PubMed · Cited by 156 · see citing works
Self-citation
The effects of vestibular system lesions on autonomic regulation: Observations, mechanisms, and clinical implications
Yates, B. J., & Bronstein, A. M. (2005) · Journal of Vestibular Research · doi:10.3233/ves-2005-15301 · Cited by 156 · see citing works
Ocular torsion in upright and tilted positions during hypo- and hypergravity of parabolic flight.
Diamond, S. G., & Markham, C. H. (1988) · PubMed · Cited by 151 · see citing works
Otolith tilt-translation reinterpretation following prolonged weightlessness: implications for preflight training.
Parker, D. E., Reschke, M. F., Arrott, A. P., Homick, J. L., & Lichtenberg, B. K. (1985) · PubMed · Cited by 150 · see citing works
Aspects of body self-calibration
Lackner, J. R., & DiZio, P. A. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01493-5 · Cited by 148 · see citing works
Self-citation
Space motion sickness during 24 flights of the space shuttle.
Davis, J. R., Vanderploeg, J. M., Santy, P. A., Jennings, R. T., & Stewart, D. F. (1988) · PubMed · Cited by 145 · see citing works
The influence of gravitoinertial force level on oculomotor and perceptual responses to sudden stop stimulation.
DiZio, P. A., Lackner, J. R., & Evanoff, J. N. (1987) · PubMed · Cited by 141 · see citing works
Self-citation
Head Movements Elicit Motion Sickness during Exposure to Microgravity and Macrogravity Acceleration Levels1
Lackner, J. R., & Graybiel, A. (2015) · KARGER eBooks · doi:10.1159/000410323 · Cited by 138 · see citing works
Self-citation
Altered Sensory-Motor Control of the Head as an Etiological Factor in Space-Motion Sickness
Lackner, J. R., & Dizio, P. (1989) · Perceptual and Motor Skills · doi:10.2466/pms.1989.68.3.784 · Cited by 136 · see citing works
Self-citation
Tachygastria and motion sickness.
Stern, R. M., Koch, K. L., Leibowitz, H. W., Lindblad, I. M., Shupert, C. L., & Stewart, W. (1985) · PubMed · Cited by 134 · see citing works
General Autonomic Components of Motion Sickness
Cowings, P. S., Suter, S., Toscano, W. B., et al. (1986) · Psychophysiology · doi:10.1111/j.1469-8986.1986.tb00671.x · Cited by 127 · see citing works
MOTION SICKNESS
Tyler, D. B., & Bard, P. (1949) · Physiological Reviews · doi:10.1152/physrev.1949.29.4.311 · Cited by 125 · see citing works
Untitled work
(1999) · PubMed · Cited by 113 · see citing works
Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space
Graebe, A., Schuck, E. L., Lensing, P., Putcha, L., & Derendorf, H. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004267193 · Cited by 113 · see citing works
M.I.T./Canadian vestibular experiments on the Spacelab-1 mission: 4. Space motion sickness: symptoms, stimuli, and predictability
Oman, C. M., Lichtenberg, B. K., Money, K. E., & Mccoy, R. K. (1986) · Experimental Brain Research · doi:10.1007/bf00237749 · Cited by 113 · see citing works
Fluid shifts in weightlessness.
Thornton, W. E., Moore, T. P., & Pool, S. L. (1987) · PubMed · Cited by 110 · see citing works
Vestibular autonomic regulation
Yates, B. J., & Miller, A. D. (1996) · CRC Press eBooks · Cited by 107 · see citing works
Vestibular Influences on the Autonomic Nervous Systema
Yates, B. J. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb15720.x · Cited by 107 · see citing works
The Ca2+-sensing receptor couples to Gα12/13 to activate phospholipase D in Madin-Darby canine kidney cells
Huang, C., Hujer, K. M., Wu, Z., et al. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00229.2003 · Cited by 106 · see citing works
Space shuttle inflight and postflight fluid shifts measured by leg volume changes.
Moore, T. P., & Thornton, W. E. (1987) · PubMed · Cited by 105 · see citing works
Untitled work
(1991) · PubMed · Cited by 105 · see citing works
A MODEL FOR VESTIBULAR FUNCTION IN ALTERED GRAVITATIONAL STATES
von Baumgarten, R. J., & Thümler, R. (1979) · Elsevier eBooks · doi:10.1016/b978-0-08-023416-8.50025-8 · Cited by 104 · see citing works
Importance of the vestibular system in visually induced nausea and self-vection
Johnson, W. H., Sunahara, F. A., & Landolt, J. P. (1999) · Journal of Vestibular Research · doi:10.3233/ves-1999-9202 · Cited by 100 · see citing works
Vestibular autonomic regulation (including motion sickness and the mechanism of vomiting)
Balaban, C. D. (1999) · Current Opinion in Neurology · doi:10.1097/00019052-199902000-00005 · Cited by 100 · see citing works
Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular system
Yates, B. J., & Kerman, I. A. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00028-9 · Cited by 100 · see citing works
Comparison of the effects of a selective muscarinic receptor antagonist and hyoscine (scopolamine) on motion sickness, skin conductance and heart rate
Golding, J. F., & Stott, J. R. R. (1997) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1997.00606.x · Cited by 99 · see citing works
The relation of motion sickness to the spatial?temporal properties of velocity storage
Dai, M., Kunin, M., Raphan, T., & Cohen, B. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1479-4 · Cited by 90 · see citing works
The stability of individual patterns of autonomic responses to motion sickness stimulation
Cowings, P. S., Naifeh, K. H., & Toscano, W. B. (1990) · Journal of Sound and Vibration · doi:10.1016/0022-460x(90)90748-o · Cited by 82 · see citing works
Cardiovascular responses elicited by linear acceleration in humans
Yates, B. J., Aoki, M., Burchill, P. M., Bronstein, A. M., & Gresty, M. A. (1999) · Experimental Brain Research · doi:10.1007/s002210050705 · Cited by 81 · see citing works
Blood flow and pressure in the giraffe carotid artery
Citters, R. L. V., Kemper, W. S., & FRANKLIN, D. L. (1968) · Comparative Biochemistry and Physiology · doi:10.1016/0010-406x(68)90816-5 · Cited by 76 · see citing works
Autonomic reaction to vestibular damage
Yates, B. J. (1998) · Otolaryngology · doi:10.1016/s0194-5998(98)70179-2 · Cited by 71 · see citing works
Clinical characterization and etiology of space motion sickness.
Thornton, W. E., Moore, T. P., Pool, S. L., & Vanderploeg, J. M. (1987) · PubMed · Cited by 69 · see citing works
Untitled work
(1983) · PubMed · Cited by 68 · see citing works
Experiment M131. Human vestibular function
Graybiel, A., Miller, E. F., & Homick, J. L. (1977) · NASA Technical Reports Server (NASA) · Cited by 68 · see citing works
Space motion sickness: phenomenology, countermeasures, and mechanisms
Ei, M., Yakovleva, I. Y., Tarasov, I. K., Vn, A., Kornilova, L. N., Mateev, A. D., & Gorgiladze, G. I. (1983) · Journal of Sound and Vibration · doi:10.1016/0022-460x(83)90820-9 · Cited by 66 · see citing works
Motion sickness susceptibility fluctuates through the menstrual cycle.
Golding, J. F., Kadzere, P., & Gresty, M. A. (2005) · PubMed · Cited by 66 · see citing works
Managing Space Motion Sickness
Jennings, R. T. (1998) · Journal of Vestibular Research · doi:10.3233/ves-1998-8110 · Cited by 66 · see citing works
Relationship between motion sickness, migraine and menstruation in crew members of a “round the world” yacht race
Grunfeld, E. A., & Gresty, M. A. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00099-9 · Cited by 66 · see citing works
Autogenic‐Feedback Training Exercise Is Superior to Promethazine for Control of Motion Sickness Symptoms
Cowings, P. S., & Toscano, W. B. (2000) · The Journal of Clinical Pharmacology · doi:10.1177/009127000004001010 · Cited by 65 · see citing works
Vertical linear self-motion perception during visual and inertial motion: More than weighted summation of sensory inputs
Wright, W. G., DiZio, P. A., & Lackner, J. R. (2005) · Journal of Vestibular Research · doi:10.3233/ves-2005-15402 · Cited by 65 · see citing works
Self-citation
Untitled work
(1991) · PubMed · Cited by 65 · see citing works
Motion sickness: a special case of sensory rearrangement.
REASON, J. T. (1970) · PubMed · Cited by 65 · see citing works
Untitled work
(1968) · PubMed · Cited by 64 · see citing works
Electrogastrography: Current Issues in Validation and Methodology
Stern, R. M., Koch, K. L., Stewart, W. R., & Vasey, M. W. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb01862.x · Cited by 63 · see citing works
Sensory Conflict Theory and Space Sickness: Our Changing Perspective
Oman, C. M. (1998) · Journal of Vestibular Research · doi:10.3233/ves-1998-8107 · Cited by 61 · see citing works
Simulation of space adaptation syndrome on earth
Ockels, W., Furrer, R., & Messerschmid, E. (1990) · Experimental Brain Research · doi:10.1007/bf00229334 · Cited by 61 · see citing works
The Biomedical Challenges of Space Flight
Williams, D. R. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152215 · Cited by 61 · see citing works
RELATIONS BETWEEN MOTION SICKNESS SUSCEPTIBILITY, THE SPIRAL AFTER‐EFFECT AND LOUDNESS ESTIMATION
REASON, J. T. (1968) · British Journal of Psychology · doi:10.1111/j.2044-8295.1968.tb01153.x · Cited by 61 · see citing works
Untitled work
(1999) · PubMed · Cited by 61 · see citing works
On Predictive Equations for Subjective Judgments of Vertical and Horizon in a Force Field
Correia, M. J., Hixson, W. C., & Niven, J. I. (1968) · Acta Oto-Laryngologica · doi:10.3109/00016486809122119 · Cited by 60 · see citing works
Alterations in R–R variability associated with experimental motion sickness
Doweck, I., Gordon, C. R., Shlitner, A., et al. (1997) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(97)00090-8 · Cited by 59 · see citing works
Adaptive plasticity in vestibular influences on cardiovascular control
Yates, B. J., Holmes, M. J., & Jian, B. J. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00302-6 · Cited by 59 · see citing works
Coriolis effects and motion sickness modelling
Bles, W. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00089-6 · Cited by 59 · see citing works
Asian Hypersusceptibility to Motion Sickness
Stern, R. M., Hu, S., Uijtdehaage, S. H. J., et al. (1996) · Human Heredity · doi:10.1159/000154318 · Cited by 57 · see citing works
The Critical Role of Velocity Storage in Production of Motion Sickness
Cohen, B., Dai, M., & Raphan, T. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1303.034 · Cited by 57 · see citing works
A provocative test for grading susceptibility to motion sickness yielding a single numerical score.
Ef, M., & Graybiel, A. (1970) · PubMed · Cited by 57 · see citing works
Perceived self-motion in two visual contexts: Dissociable mechanisms underlie perception
Wright, W. G., DiZio, P. A., & Lackner, J. R. (2006) · Journal of Vestibular Research · doi:10.3233/ves-2006-161-202 · Cited by 56 · see citing works
Self-citation
Untitled work
(1980) · PubMed · Cited by 56 · see citing works
Untitled work
(1993) · PubMed · Cited by 54 · see citing works
Role Of The Vestibular System In Regulating Respiratory Muscle Activity During Movement
Yates, B., Billig, I., Cotter, L., Mori, R., & Card, J. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03612.x · Cited by 54 · see citing works
European vestibular experiments on the Spacelab-1 mission: 1. Overview
von Baumgarten, R. J. (1986) · Experimental Brain Research · doi:10.1007/bf00237739 · Cited by 53 · see citing works
CARDIORESPIRATORY DYNAMICS IN THE OX AND GIRAFFE, WITH COMPARATIVE OBSERVATIONS ON MAN AND OTHER MAMMALS*
Patterson, J. L., Goetz, R. H., Doyle, J. T., et al. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb49416.x · Cited by 53 · see citing works
The Menstrual Cycle and Susceptibility to Virtual Simulation Sickness
Clemes, S. A., & Howarth, P. A. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730404272567 · Cited by 52 · see citing works
Untitled work
(1977) · PubMed · Cited by 51 · see citing works
Structure of the lymphoid organs of elasmobranchs
Zapata, A. G., Torroba, M., Sacedón, R., Varas, A., & Vicente, Á. (1996) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19960601/15)275:2/3 · Cited by 51 · see citing works
Noxious stimulation of emesis.
Lang, I. M. (1999) · PubMed · Cited by 50 · see citing works
Lack of gender difference in motion sickness induced by vestibular Coriolis cross-coupling
Cheung, B., & Hofer, K. (2003) · Journal of Vestibular Research · doi:10.3233/ves-2003-12405 · Cited by 50 · see citing works
Structural elements in the concept of motion sickness.
Graybiel, A. (1969) · PubMed · Cited by 50 · see citing works
Perspectives of electrogastrography and motion sickness
Cheung, B., & Vaitkus, P. J. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00095-1 · Cited by 48 · see citing works
Effect of neurovestibular stimulation on autonomic regulation
da Costa, F. A. A., Lavin, P., Robertson, D., et al. (1995) · Clinical Autonomic Research · doi:10.1007/bf01818894 · Cited by 47 · see citing works
Promethazine as a motion sickness treatment: impact on human performance and mood states.
Cowings, P. S., Toscano, W. B., DEROSHIA, C. W., et al. (2000) · PubMed · Cited by 43 · see citing works
Untitled work
(1982) · PubMed · Cited by 43 · see citing works
Motion sickness susceptibility and related behavioral characteristics in men and women.
Lentz, J. M., & Collins, W. E. (1977) · PubMed · Cited by 43 · see citing works
Asymmetric otolith function and increased susceptibility to motion sickness during exposure to variations in gravitoinertial acceleration level.
Lackner, J. R., Graybiel, A., Johnson, W. H., et al. (1987) · PubMed · Cited by 42 · see citing works
Self-citation
Evaluation of the Relationship Between C*, δ5, and δt during Creep Crack Growth
Saxena, A., Dogan, B., & Schwalbe, K.-H. (1994) · doi:10.1520/stp13724s · Cited by 42 · see citing works
Space motion sickness monitoring experiment - Spacelab 1
Oman, C. M., Lichtenberg, B. K., & Money, K. E. (1984) · Cited by 42 · see citing works
Human Heart Rate Variability Relation Is Unchanged During Motion Sickness
Mullen, T. J., Berger, R. D., Oman, C. M., & Cohen, R. J. (1998) · Journal of Vestibular Research · doi:10.3233/ves-1998-8113 · Cited by 42 · see citing works
Individual differences in susceptibility to motion sickness among six Skylab astronauts
Graybiel, A., Miller, E. F., & Homick, J. L. (1975) · Acta Astronautica · doi:10.1016/0094-5765(75)90051-x · Cited by 42 · see citing works
Adaptation to vection-induced symptoms of motion sickness.
Stern, R. M., Hu, S., Vasey, M. W., & Koch, K. L. (1989) · PubMed · Cited by 41 · see citing works
Effect of gravitoinertial force on ocular counterrolling.
Miller, E. F., & Graybiel, A. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.5.697 · Cited by 41 · see citing works
The effective intensity of Coriolis, cross-coupling stimulation is gravitoinertial force dependent: implications for space motion sickness.
Lackner, J. R., & Graybiel, A. (1986) · PubMed · Cited by 40 · see citing works
Self-citation
Preflight Adaptation Training for Spatial Orientation and Space Motion Sickness
Harm, D. L., & Parker, D. E. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb02015.x · Cited by 40 · see citing works
Therapeutic effects of antimotion sickness medications on the secondary symptoms of motion sickness.
Cd, W., Jj, S., Mj, W., et al. (1990) · PubMed · Cited by 39 · see citing works
Use of Promethazine to Hasten Adaptation to Provocative Motion
Lackner, J. R., & Graybiel, A. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb02018.x · Cited by 39 · see citing works
Self-citation
Comparison of treatment strategies for Space Motion Sickness
Davis, J. R., Jennings, R. T., & Beck, B. (1993) · Acta Astronautica · doi:10.1016/0094-5765(93)90074-7 · Cited by 39 · see citing works
Body volume changes during simulated microgravity: Auditory changes, segmental fluid redistribution, and regional hemodynamics
Montgomery, L. D., Parmet, A. J., & Booher, C. R. (1993) · Annals of Biomedical Engineering · doi:10.1007/bf02368634 · Cited by 37 · see citing works
XXVII A Comparison of the Symptomatology Experienced by Healthy Persons and Subjects with Loss of Labyrinthine Function When Exposed to Unusual Patterns of Centripetal Force in a Counter-Rotating Room
Graybiel, A., & Johnson, W. H. (1963) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348946307200206 · Cited by 37 · see citing works
A Retrospective Study of Promethazine and Its Failure to Produce the Expected Incidence of Sedation During Space Flight
Bagian, J. P., & Ward, D. F. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb02019.x · Cited by 35 · see citing works
Motion sickness incidence during a round-the-world yacht race.
Turner, M., & Griffin, M. J. (1995) · PubMed · Cited by 35 · see citing works
Validating the Hypothesis of Otolith Asymmetry as a Cause of Space Motion Sickness
Diamond, S. G., & Markham, C. H. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25250.x · Cited by 34 · see citing works
Space motion sickness: Skylab revisited.
Graybiel, A. (1980) · PubMed · Cited by 33 · see citing works
Gastrointestinal motility in space motion sickness.
Thornton, W. E., Linder, B. J., Moore, T. P., & Pool, S. L. (1987) · PubMed · Cited by 33 · see citing works
Roll motion stimuli: sensory conflict, perceptual weighting and motion sickness
de Graaf, B., Bles, W., & Bos, J. E. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00116-6 · Cited by 33 · see citing works
Horizontal Angular VOR, Nystagmus Dumping, and Sensation Duration in Spacelab SLS-1 Crewmembers
Oman, C. M., & Balkwill, M. D. (1993) · Journal of Vestibular Research · doi:10.3233/ves-1993-3312 · Cited by 31 · see citing works
Effects of baclofen on the angular vestibulo-ocular reflex
Dai, M., Raphan, T., & Cohen, B. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0264-y · Cited by 31 · see citing works
Space motion sickness: Symptoms, stimuli and predictability
Oman, C. M., Lichtenberg, B. K., Money, K. E., et al. (1983) · NASA Technical Reports Server (NASA) · Cited by 30 · see citing works
Untitled work
(1969) · PubMed · Cited by 30 · see citing works
Objective and Subjective Time Courses of Recovery from Motion Sickness Assessed by Repeated Motion Challenges
Golding, J. F., & Stott, J. (1997) · Journal of Vestibular Research · doi:10.3233/ves-1997-7601 · Cited by 30 · see citing works
Plastic changes in processing of graviceptive signals during spaceflight potentially contribute to postflight orthostatic intolerance
Yates, B. J., Holmes, M. J., & Jian, B. J. (2003) · Journal of Vestibular Research · doi:10.3233/ves-2003-134-621 · Cited by 29 · see citing works
A Predictive Test for Space Motion Sickness
Markham, C. H., & Diamond, S. G. (1993) · Journal of Vestibular Research · doi:10.3233/ves-1993-3309 · Cited by 29 · see citing works
Untitled work
(1987) · PubMed · Cited by 28 · see citing works
Progressive adaptation to Coriolis accelerations associated with 1-rpm increments in the velocity of the slow rotation room.
REASON, J. T., & Graybiel, A. (1970) · PubMed · Cited by 28 · see citing works
First Intramuscular Administration in the U.S. Space Program
Bagian, J. P. (1991) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1991.tb03649.x · Cited by 28 · see citing works
Horizontal angular VOR changes in orbital and parabolic flight: human neurovestibular studies on SLS-2
Oman, C. M., Pouliot, C. F., & Natapoff, A. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.69 · Cited by 28 · see citing works
Reducing motion sickness: a comparison of autogenic-feedback training and an alternative cognitive task.
Toscano, W. B., & Cowings, P. S. (1982) · PubMed · Cited by 27 · see citing works
Pharmacology of Motion Sickness
Lucot, J. B. (1998) · Journal of Vestibular Research · doi:10.3233/ves-1998-8109 · Cited by 27 · see citing works
Physiological and behavioral effects of tilt-induced body fluid shifts.
Parker, D. E., Tjernström, Ö., Ivarsson, A., et al. (1983) · PubMed · Cited by 25 · see citing works
Spatial orientation and balance control changes induced by altered gravitoinertial force vectors
Paloski, W. H., Gianna, C. C., Black, F. O., Kaufman, G. D., & Wood, S. J. (2001) · Experimental Brain Research · doi:10.1007/s002210000636 · Cited by 25 · see citing works
Space Sickness and Fluid Shifts: A Hypothesis
Simanonok, K. E., & Charles, J. B. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb02020.x · Cited by 25 · see citing works
Motion sickness susceptibility and aerobic fitness: a longitudinal study.
Cheung, B., Money, K. E., & Jacobs, I. (1990) · PubMed · Cited by 25 · see citing works
A sustained hyper-g load as a tool to simulate space sickness.
Bles, W., de Graaf, B., Bos, J. E., Groen, E. L., & Krol (1997) · PubMed · Cited by 25 · see citing works
Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea.
Kl, K. (1999) · PubMed · Cited by 24 · see citing works
Untitled work
(1998) · PubMed · Cited by 24 · see citing works
Motion sickness susceptibility in parabolic flight and velocity storage activity.
DiZio, P. A., & Lackner, J. R. (1991) · PubMed · Cited by 23 · see citing works
Self-citation
Reliability of Psychophysiological Responses Across Multiple Motion Sickness Stimulation Tests
Stout, C. S., Toscano, W. B., & Cowings, P. S. (1995) · Journal of Vestibular Research · doi:10.3233/ves-1995-5103 · Cited by 23 · see citing works
Effect of direction of head movement on motion sickness caused by Coriolis stimulation.
Woodman, P. D., & Griffin, M. J. (1997) · PubMed · Cited by 23 · see citing works
Nausogenic properties of various dynamic and static force environments
von Baumgarten, R. J., Vogel, H., & Kass, J. R. (1981) · Acta Astronautica · doi:10.1016/0094-5765(81)90072-2 · Cited by 23 · see citing works
Predicting motion sickness during parabolic flight
Harm, D. L., & Schlegel, T. T. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00043-7 · Cited by 23 · see citing works
Labyrinth and cerebral-spinal fluid pressure changes in guinea pigs and monkeys during simulated zero G.
Parker, D. E. (1977) · PubMed · Cited by 22 · see citing works
Physiology of motion sickness symptoms
Harm, D. L. (1990) · NASA Technical Reports Server (NASA) · Cited by 22 · see citing works
Spacelab experiments on space motion sickness
Oman, C. M. (1987) · Acta Astronautica · doi:10.1016/0094-5765(87)90066-x · Cited by 21 · see citing works
Space adaptation syndrome: Incidence and operational implications for the space transportation system program
Homick, J. L., Reschkle, M. F., & Vanderploeg, J. M. (1984) · NASA Technical Reports Server (NASA) · Cited by 20 · see citing works
Measurement of Otolith Function in Man
Graybiel, A. (1974) · Handbook of sensory physiology · doi:10.1007/978-3-642-65920-1_4 · Cited by 20 · see citing works
Optokinetic motion sickness: attenuation of visually-induced apparent self-rotation by passive head movements.
Teixeira, R. A., & Lackner, J. R. (1979) · PubMed · Cited by 20 · see citing works
Self-citation
Elicitation of motion sickness by head movements in the microgravity phase of parabolic flight maneuvers.
Lackner, J. R., & Graybiel, A. (1984) · PubMed · Cited by 20 · see citing works
Self-citation
The menstrual cycle and susceptibility to coriolis-induced sickness
Cheung, B., Heskin-Sweezie, R., Hofer, K., & Gagnon, M. (2001) · Journal of Vestibular Research · doi:10.3233/ves-2001-11207 · Cited by 20 · see citing works
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness.
Markham, C. H., & Diamond, S. G. (1992) · PubMed · Cited by 20 · see citing works
Treatment of motion sickness in parabolic flight with buccal scopolamine.
Norfleet, W. T., Degioanni, J. J., Calkins, D. S., et al. (1992) · PubMed · Cited by 19 · see citing works
General remarks on the role of the vestibular system in weightlessness
von Baumgarten, R. J. (1987) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/bf00464257 · Cited by 18 · see citing works
Instability of ocular torsion in zero gravity: possible implications for space motion sickness.
Diamond, S. G., Markham, C. H., & Money, K. E. (1990) · PubMed · Cited by 17 · see citing works
Car‐sickness in Twins
BAKWIN, H. T. (1971) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1971.tb03267.x · Cited by 17 · see citing works
Altered sensorimotor control of the body as an etiological factor in space motion sickness.
Lackner, J. R., Graybiel, A., & DiZio, P. A. (1991) · PubMed · Cited by 17 · see citing works
Self-citation
Comparison of susceptibility to motion sickness during rotation at 30 rpm in the earth-horizontal, 10 degrees head-up, and 10 degrees head-down positions.
Graybiel, A., & Lackner, J. R. (1977) · PubMed · Cited by 16 · see citing works
Self-citation
Otolith organ activity within earth standard, one-half standard and zero gravity environments.
Miller, E. F., Graybiel, A., & Kellogg, R. S. (1965) · PubMed · Cited by 16 · see citing works
A new nausea model in humans produces mild nausea without electrogastrogram and vasopressin changes
Kiernan, B. D., Soykan, İ., Lin, Z., et al. (1997) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1997.d01-61.x · Cited by 16 · see citing works
Changes in the vestibular function during space flight
Gurovskiy, N. N., Bryanov, I. I., & Yegorov, A. D. (1975) · Acta Astronautica · doi:10.1016/0094-5765(75)90091-0 · Cited by 16 · see citing works
The effect of autogenic training and biofeedback on motion sickness tolerance.
Jozsvai, E. E., & Pigeau, R. A. (1996) · PubMed · Cited by 16 · see citing works
Effect of sickness severity on habituation to repeated motion challenges in aircrew referred for airsickness treatment.
Golding, J. F., & Stott, J. (1995) · PubMed · Cited by 16 · see citing works
Motion sickness, vascular changes accompanying pseudo-coriolis-induced nausea.
Johnson, W. H., Sunahara, F. A., & Landolt, J. P. (1993) · PubMed · Cited by 15 · see citing works
Parabolic flight reveals independent binocular control of otolith-induced eye torsion.
Markham, C. H., Diamond, S. G., & Stoller, D. F. (2000) · PubMed · Cited by 15 · see citing works
Genetical and Developmental Aspects of Susceptibility to Motion Sickness and Frost-bite
Abe, K., Amatomi, M., & Kajiyama, S. (1970) · Human Heredity · doi:10.1159/000152352 · Cited by 14 · see citing works
Anatomical Position of Heart in Snakes with Vertical Orientation: A New Hypothesis
Badeer, H. S. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(97)00444-3 · Cited by 14 · see citing works
Why do astronauts suffer space sickness?
Oman, C. M. (1984) · PubMed · Cited by 14 · see citing works
Rotation at 30 RPM about the A axis after 6 hours in the 10 degree head-down position: effect on susceptibility to motion sickness.
Graybiel, A., & Lackner, J. R. (1979) · PubMed · Cited by 13 · see citing works
Self-citation
Untitled work
(1972) · PubMed · Cited by 13 · see citing works
Development of space motion sickness in a ground-based human centrifuge
Albery, W. B., & Martin, E. T. (1996) · Acta Astronautica · doi:10.1016/0094-5765(96)00011-2 · Cited by 13 · see citing works
The absence of residual effects attributable to the otolith organs following unilateral labyrinthectomy in man
Graybiel, A., & Niven, J. I. (1953) · The Laryngoscope · doi:10.1288/00005537-195301000-00002 · Cited by 13 · see citing works
Statistical prediction of space motion sickness
Reschke, M. F. (1990) · NASA Technical Reports Server (NASA) · Cited by 12 · see citing works
A sudden-stop vestibulovisual test for rapid assessment of motion sickness manifestations
Graybiel, A., & Lackner, J. R. (1980) · Journal of Sound and Vibration · doi:10.1016/0022-460x(80)90681-1 · Cited by 12 · see citing works
Self-citation
Salivary changes associated with seasickness
Gordon, C. R., Ben‐Aryeh, H., Szargel, R., et al. (1989) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(89)90105-7 · Cited by 12 · see citing works
Otolith Function in Hypo- and Hypergravity: Relation to Space Motion Sickness
Diamond, S. G., & Markham, C. H. (1991) · Acta Oto-Laryngologica · doi:10.3109/00016489109131335 · Cited by 11 · see citing works
Physiological effects induced by antiorthostatic hypokinesia.
Kakurin, L. I., Kuz'min, M. P., Ei, M., et al. (1976) · PubMed · Cited by 11 · see citing works
Ocular counterrolling measured during eight hours of sustained body tilt
Miller, E. F., & Graybiel, A. (1972) · PsycEXTRA Dataset · doi:10.1037/e479312008-001 · Cited by 10 · see citing works
Pharmacotherapeutics in space.
Putcha, L. (1999) · PubMed · Cited by 10 · see citing works
The vestibular system and cardiovascular responses to altered gravity
Yates, B. J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00576.2003 · Cited by 9 · see citing works
Nystagmus, turning sensations, and illusory movement in motion sickness susceptibility.
Lentz, J. M. (1976) · PubMed · Cited by 9 · see citing works
Pharmacological interventions for motion sickness: cardiovascular effects.
Sunahara, F. A., Farewell, J., Mintz, L., et al. (1987) · PubMed · Cited by 9 · see citing works
Prevention of overt motion sickness by incremental exposure to otherwise highly stressful Coriolis accelerations. NAMI-1044.
Graybiel, A., Deane, F. R., & Colehour, J. K. (1968) · PubMed · Cited by 8 · see citing works
Electrical vestibular stimulation and space motion sickness
Cauquil, A. S. (1992) · Acta Astronautica · doi:10.1016/0094-5765(92)90044-j · Cited by 8 · see citing works
Sudden emesis following parabolic flight maneuvers: implications for space motion sickness.
Lackner, J. R., & Graybiel, A. (1986) · PubMed · Cited by 7 · see citing works
Self-citation
I am Eagle
Titov, G., & Caidin, M. (1962) · Medical Entomology and Zoology · Cited by 7 · see citing works
Effect of environmental temperature on sweat onset during motion sickness.
McClure, J. A., & Fregly, A. R. (1972) · PubMed · Cited by 6 · see citing works
Of what importance are psychological factors in motion sickness?
Wendt, G. R. (1948) · PubMed · Cited by 6 · see citing works
THE EFFECT OF GRAVITOINERTIAL FORCE UPON OCULAR COUNTERROLLING
Miller, E. F., Graybiel, I. I., & Ashton (1970) · doi:10.21236/ad0707124 · Cited by 5 · see citing works
Diuretic as a means for rapid adaptation to weightlessness
Noskov, V. B., & Grigoriev, A. I. (1994) · Acta Astronautica · doi:10.1016/0094-5765(94)90091-4 · Cited by 5 · see citing works
Physiological responses to visually induced motion sickness
Lawson, B. D., Sunahara, F. A., & Lackner, J. R. (1991) · The Society for Neuroscience Abstracts · Cited by 4 · see citing works
Self-citation
Successful Transfer Of Adaptation Acquired In A Slow Rotation Room To Motion Environments In Navy Flight Training
Cramer, D. B., Graybiel, A., & Oosterveld, W. J. (1978) · Acta Oto-Laryngologica · doi:10.3109/00016487809121426 · Cited by 3 · see citing works
Studies of Motion Sickness: X. Experimental Proof that Aviation Cadets Tell the Truth on Motion Sickness History Questionnaires
Alexander, S. J., Cotzin, M., Hill, C. J., et al. (1955) · The Journal of Psychology · doi:10.1080/00223980.1955.9916189 · Cited by 1 · see citing works
Successful Transfer of Adaptation Acquired in a Slow Rotation Room to Motion Environments in Navy Flight Training,
Cramer, D. B., Graybiel, A., & Oosterveld, W. J. (1976) · doi:10.21236/ada118013 · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

The virtual reality head-mounted display Oculus Rift induces motion sickness and is sexist in its effects
Munafo, J., Diedrick, M., & Stoffregen, T. A. (2017) · Experimental Brain Research · doi:10.1007/s00221-016-4846-7 · Cited by 566 · see citing works
Motion sickness: more than nausea and vomiting
Lackner, J. R. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4008-8 · Cited by 314 · see citing works
Self-citation
Vestibulo‐Sympathetic Responses
Yates, B. J., Bolton, P. S., & Macefield, V. G. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130041 · Cited by 160 · see citing works
Less sickness with more motion and/or mental distraction
Bos, J. E. (2015) · Journal of Vestibular Research · doi:10.3233/ves-150541 · Cited by 123 · see citing works
Integration of vestibular and emetic gastrointestinal signals that produce nausea and vomiting: potential contributions to motion sickness
Yates, B. J., Catanzaro, M. F., Miller, D. J., & McCall, A. A. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3937-6 · Cited by 90 · see citing works
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment
Chen, W., Chao, J.-G., Chen, X.-W., Wang, J.-K., & Tan, C. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.01.007 · Cited by 29 · see citing works
Impact of oral vitamin C on histamine levels and seasickness
Jarisch, R., Weyer, D., Ehlert, E., Koch, C. H., Pinkowski, E., Jung, P., Kähler, W., Girgensohn, R., Kowalski, J., Weisser, B., et al. (2014) · Journal of Vestibular Research · doi:10.3233/ves-140509 · Cited by 17 · see citing works
Pharmaceutical Countermeasures Have Opposite Effects on the Utricles and Semicircular Canals in Man
Weerts, A. P., De Meyer, G., Pauwels, G., Vanspauwen, R., Dornhoffer, J. L., Van de Heyning, P. H., & Wuyts, F. L. (2012) · Audiology and Neurotology · doi:10.1159/000337273 · Cited by 12 · see citing works

Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight
Horie, K., Kato, T., Kudo, T., Sasanuma, H., Miyauchi, M., Akiyama, N., Miyao, T., Seki, T., Ishikawa, T., Takakura, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56432-9 · Cited by 41 · see citing works
Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation
Martinez, E. M., Yoshida, M., Candelario, T. L. T., & Hughes‐Fulford, M. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00449.2014 · Cited by 88 · see citing works
Changes in the astronaut serum proteome during prolonged spaceflight
Kimura, Y., Nakai, Y., Ino, Y., Akiyama, T. H., Moriyama, K., Aiba, T., Ohira, T., Egashira, K., Yamamoto, Y., Takeda, Y., et al. (2024) · PROTEOMICS · doi:10.1002/pmic.202300328 · Cited by 6 · see citing works
High dose ondansetron for reducing motion sickness in highly susceptible subjects.
Muth, E. R., & Elkins, A. N. (2007) · PubMed · Cited by 19 · see citing works
Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight
Chakraborty, N., Zamarioli, A., Gautam, A., Campbell, R., Mendenhall, S. K., Childress, P., Dimitrov, G. I., Sowe, B., Tucker, A., Zhao, L., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.05.050 · Cited by 16 · see citing works

Authors: Lackner, J. R., & DiZio, P.
Affiliations: Brandeis University (US)
Corresponding author: Lackner, James R.
ORCID: Lackner, James R.
DiZio, Paul
Venue: Experimental Brain Research
Publisher: Springer Science and Business Media LLC
Published: 2006-10-05
Volume: 175
Issue: 3
Pages: 377-399
ISSN: 0014-4819 (ISSN-L)
1432-1106
DOI: 10.1007/s00221-006-0697-y
OpenAlex: W2160904244
Cited by: 163
References: 190
Citations by year: 2026: 3 · 2025: 16 · 2024: 13 · 2023: 17 · 2022: 16 · 2021: 10 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 2 · 2012: 7
FWCI: 0.47
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Experimental Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords: space motion sickness, motion sickness, spaceflight, fluid shifts, head movement, otolith asymmetry, susceptibility prediction, vestibular physiology
MeSH terms: Humans, Motion Sickness, Space Flight, Weightlessness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Space motion sickness

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks