Cellular localization of serotonin2A (5HT2A) receptors in the rat brain
Abstract
The serotonin(2A) (5HT(2A)) receptors have been shown to play an important role in several psychiatric disorders, including depression, schizophrenia, and alcoholism. This immunohistochemical study examined the cellular localization of 5HT(2A) receptors in various rat brain structures (olfactory, striatum, cortex, hippocampus, and amygdala). The colocalization of 5HT(2A) receptors in astrocytes was performed by double-immunofluorescence staining of 5HT(2A) receptors and of glial fibrillary acidic protein (GFAP) using confocal laser microscopy. 5HT(2A) receptor immunolabeling was observed in olfactory bulbs, neostriatum, hippocampus, amygdala, and neocortex. Somata and dendrites of pyramidal cells in the frontal cortex (layer V) were densely labeled with 5HT(2A) receptors. In several other brain structures (hippocampus, amygdala, striatum, olfactory structures), 5HT(2A) receptor immunolabeling was found in cell bodies and processes of neurons. 5HT(2A) receptor immunolabeling was also observed in GFAP-positive cells of the various brain structures we investigated (layers I/VI of the neocortex, corpus callosum, hippocampal fissure and hilus, and amygdala). These results indicate that 5HT(2A) receptors are expressed in neurons and astrocytes and suggest the possibility that not only neuronal but also glial 5HT(2A) receptors have functional implications in psychiatric disorders.
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In rodents, the 5-HT2A receptor expression pattern has been confirmed using immunohistochemistry, light and electron microscope immunocytochemistry, in situ hybridization, receptor autoradiography, and transgenic mice expressing EGFP under control of the 5-HT2A receptor promoter.
“In rodents, this expression pattern has been confirmed using immunohistochemistry (203–206), light and electron microscope immunocytochemistry (203), in situ hybridization (207, 208), receptor autoradiography (209), and transgenic mice expressing EGFP under control of the 5-HT2A receptor promoter (210).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [204]
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- Authors
- Xu, T., & Pandey, S. C.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Pandey, Subhash C
- ORCID
- Pandey, Subhash C
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 51
- Issue
- 6
- Pages
- 499-505
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W1555828690
- Cited by
- 194
- References
- 32
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 4 · 2018: 12 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- University of Illinois at Chicago
- National Institute on Alcohol Abuse and Alcoholism (AA 10005)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- 5-HT2A receptor, receptor localization, rat brain, astrocytes, glial fibrillary acidic protein, olfactory bulb, neostriatum, hippocampus, amygdala, neocortex, pyramidal neurons, mental illness, schizophrenia, depression, alcoholism
- MeSH terms
- Amygdala, Animals, Astrocytes, Basal Ganglia, Brain, Cerebral Cortex, Fluorescent Antibody Technique, Glial Fibrillary Acidic Protein, Hippocampus, Male, Neurons, Olfactory Pathways, Receptors, Serotonin, Rats, Sprague-Dawley, Receptor, Serotonin, 5-HT2A, Rats
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