Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT 1A receptors
Abstract
Systemic administration of cannabidiol (CBD) attenuates cardiovascular and behavioral changes induced by re-exposure to a context that had been previously paired with footshocks. Previous results from our group using cFos immunohistochemistry suggested that the bed nucleus of the stria terminalis (BNST) is involved in this effect. The mechanisms of CBD effects are still poorly understood, but could involve 5-HT(1A) receptor activation. Thus, the present work investigated if CBD administration into the BNST would attenuate the expression of contextual fear conditioning and if this effect would involve the activation of 5-HT(1A) receptors. Male Wistar rats with cannulae bilaterally implanted into the BNST were submitted to a 10 min conditioning session (six footshocks, 1.5 mA/3 s). Twenty-four hours later freezing and cardiovascular responses (mean arterial pressure and heart rate) to the conditioning box were measured for 10 min. CBD (15, 30 or 60 nmol) or vehicle was administered 10 min before the re-exposure to the aversive context. The second experiment was similar to the first one except that animals received microinjections of the 5-HT(1A) receptor antagonist WAY100635 (0.37 nmol) 5 min before CBD (30 nmol) treatment. The results showed that CBD (30 and 60 nmol) treatment significantly reduced the freezing and attenuated the cardiovascular responses induced by re-exposure to the aversive context. Moreover, WAY100635 by itself did not change the cardiovascular and behavioral response to context, but blocked the CBD effects. These results suggest that CBD can act in the BNST to attenuate aversive conditioning responses and this effect seems to involve 5-HT(1A) receptor-mediated neurotransmission.
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Systemic administration of CBD in rats exerts anxiolytic-like effects in the Vogel conflict test.
“Vogel conflict test (Campos and Guimaraes, 2008; Gomes et al., 2012; Moreira et al., 2006)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Gomes et al., 2012
Systemic administration of CBD in rats exerts anxiolytic-like effects in the elevated plus-maze.
“Systemic administration of CBD in rats exerts anxiolytic-like effects in the elevated plus-maze (Campos and Guimaraes, 2008; Campos et al., 2013b; Gomes et al., 2012; Guimaraes et al., 1990; Onaivi et al., 1990; Schiavon et al., 2016)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Gomes et al., 2012
CBD induced acute anxiolytic effects when injected into the dPAG and BNST.
“As shown in Figure 2, CBD induced acute anxiolytic effects when injected into the dPAG and BNST (21, 37–41).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [39]
The acute effects of CBD clearly depend on facilitation of serotonin 5HT1A receptor-mediated neurotransmission in defense-related areas.
“The acute effects of CBD clearly depend on facilitation of serotonin 5HT1A receptor-mediated neurotransmission in defense-related areas (28, 31, 39, 40, 42, 43, 46, 47).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [39]
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Self-citationThe endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol
Sultan, S. R., Millar, S. A., England, T. J., & O'Sullivan, S. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00081 · Cited by 95 · see citing works
“Also, in rats conditioned to stress (i.e., restraint or fear), CBD reduced the increase in HR and MBP (Resstel et al., 2006, 2009; Gomes et al., 2012).”
BackgroundInfluentialWright, M. J., Vandewater, S. A., & Taffe, M. A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12199 · Cited by 72 · see citing works
Marinho, A. L. Z., Vila-Verde, C., Fogaça, M. V., & Guimarães, F. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.023 · Cited by 68 · see citing works
Gomes, F. V., Alves, F. H. F., Guimarães, F. S., Correa, F. M. A., Resstel, L. B. M., & Crestani, C. C. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.09.007 · Cited by 27 · see citing works
- Authors
- Gomes, F. V., Reis, D. G., Alves, F. H., Corrêa, F. M., Guimarães, F. S., & Resstel, L. B.
- Affiliations
- Universidade de São Paulo (BR)
- Department of Pharmacology, School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2010-12-08
- Volume
- 26
- Issue
- 1
- Pages
- 104-113
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W1999133841
- Cited by
- 97
- References
- 90
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 10 · 2015: 6 · 2014: 1 · 2013: 7 · 2012: 7
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cannabidiol, bed nucleus of the stria terminalis, contextual fear conditioning, 5-HT1A receptor, WAY-100635, freezing behavior, cardiovascular response, mean arterial pressure, heart rate, aversive conditioning, microinjection
- MeSH terms
- Animals, Behavior, Animal, Cannabidiol, Cardiovascular Physiological Phenomena, Conditioning, Psychological, Fear, Male, Synaptic Transmission, Piperazines, Pyridines, Septal Nuclei, Rats, Wistar, Receptor, Serotonin, 5-HT1A, Rats, Serotonin 5-HT1 Receptor Antagonists
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