Cited by 167Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Serotonin and decision making processes

Homberg, Judith R.·2012·Neuroscience & Biobehavioral Reviews

Abstract

Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant, anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric disorders characterized by impaired decision making, and exert both beneficial and harmful effects in patients. Detailed insight into the serotonergic mechanisms underlying decision making is needed to strengthen the first and weaken the latter. Although much remains to be done to achieve this, accumulating studies begin to deliver a coherent view. Thus, high central 5-HT levels are generally associated with improved reversal learning, improved attentional set shifting, decreased delay discounting, and increased response inhibition, but a failure to use outcome representations. Based on 5-HT's evolutionary role, I hypothesize that 5-HT integrates expected, or changes in, relevant sensory and emotional internal/external information, leading to vigilance behaviour affecting various decision making processes. 5-HT receptor subtypes play distinctive roles in decision making. 5-HT(2A) agonists and 5-HT2c antagonists decrease compulsivity, whereas 5-HT(2A) antagonists and 5-HT(2C) agonists decrease impulsivity. 5-HT(6) antagonists univocally affect decision making processes.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2011.06.001

Cites

270 of 270 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The GM modulates the tryptophan and kynurenine pathways and is a humoral route through which the GM may influence cognition at the level of the CNS.

    “Mounting evidence suggests that the GM modulates the tryptophan and kynurenine pathways and is a humoral route through which the GM may influence cognition at the level of the CNS (206–210).”

Cites

Flagged first, then by citations

3 of the 273 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Homberg, J. R.
Affiliations
Donders Institute for Brain, Cognition and Behaviour (NL)
Corresponding author
Homberg, Judith R.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2012-01
Volume
36
Issue
1
Pages
218-236
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2015724371
Cited by
167
References
273
Citations by year
2026: 2 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 4 · 2019: 7 · 2018: 27 · 2017: 12 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 23 · 2012: 8
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
The Netherlands Organisation for Scientific Research (NWO) (86410003)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
serotonin, decision-making, reversal learning, set-shifting, delay discounting, response inhibition, serotonergic receptors, 5-HT2A receptor, 5-HT2C receptor, 5-HT6 receptor, impulsivity, compulsivity, antidepressants, anxiolytics, antipsychotic drugs, vigilance behavior
MeSH terms
Animals, Decision Making, Humans, Receptors, Serotonin, Reversal Learning, Serotonin, Serotonin Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review