The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The aphrodisiac and adaptogenic properties of ginseng
Abstract
Ginseng is the root of the perennial herbs of Panax quinquefolium and Panax ginseng which contain a series of tetracyclic triterpenoid saponins (ginsenosides) as active ingredients. It is considered a tonic or adaptogenic that enhances physical performance (including sexual), promotes vitality and increases resistance to stress and ageing. The adaptogenic properties of ginseng are believed to be due to its effects on hypothalamic-pituitary-adrenal axis, resulting in elevated plasma corticotropin and corticosteroids levels. When used appropriately, ginseng appears to be safe. Nevertheless, documented side effects include hypertension, diarrhoea, restlessness, mastalgia and vaginal bleeding.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is considered that the adaptogenic properties of Panax ginseng extract are due to the ginsenosides [27].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [27]
In the citing paper
“The exact mechanism of adaptogenic action of Panax ginseng is unknown, but it is supposed that it affects the hypothalamic-pituitary-adrenal axis in Figure 2 and the antioxidant effect [24,27,28,29].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [27]
Citations
Cites
New Substances of Plant Origin Which Increase Nonspecific Resistance
Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595
Panax ginseng pharmacology: A nitric oxide link?
Gillis, C. N. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00193-7 · Cited by 568
A Review of 12 Commonly Used Medicinal Herbs
Ohara, M. (1998) · Archives of Family Medicine · doi:10.1001/archfami.7.6.523 · Cited by 476
Ginseng abuse syndrome. Problems with the panacea
Siegel, R. (1979) · JAMA · doi:10.1001/jama.241.15.1614 · Cited by 269
Herbal Remedies in Psychiatric Practice
Wong, A. H. C., Smith, M. T., & Boon, H. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.1033 · Cited by 231
CARDIOVASCULAR PROTECTION BY GINSENOSIDES AND THEIR NITRIC OXIDE RELEASING ACTION
Chen, X. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb01767.x · Cited by 203
Siegel, R. K. (1979) · JAMA · doi:10.1001/jama.1979.03290410046024 · Cited by 192
Samuelsson, G. (1992) · Cited by 155
D’Angelo, L., Grimaldi, R., Caravaggi, M., Marcoli, M., Perucca, E., Lecchini, S., Frigo, G. M., & Crema, A. (1986) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(86)90063-2 · Cited by 146
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00003 · Cited by 143
Research works printed but not linked: 7
- Shibata, 1985, Econ Med Plant Res, 1, 217
- Sonnerborn, 1991, Br J Phytother, 2, 3
- Pieralisi, 1991, Clin Ther, 13, 373
- Choi, 1995, Int J Impot Res, 7, 181
- Guodong, 1987, Chin J Integr Trad West Med, 7, 326
- Yushu, 1988, J Trad Chin Med, 8, 293
- Nakagawa, 1985, Hiroshima J Med Sci, 34, 303
Cited by
Sorted by citations
Biological activities and distribution of plant saponins
Sparg, S. G., Light, M. E., & van Staden, J. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.05.016 · Cited by 1,469
Neuroprotective potential of phytochemicals
Kumar, G., & Khanum, F. (2012) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.99898 · Cited by 526
Panossian, A. G., Efferth, T., Shikov, A. N., Pozharitskaya, O. N., Kuchta, K., Mukherjee, P. K., Banerjee, S., Heinrich, M., Wu, W., Guo, D., et al. (2021) · Medicinal Research Reviews · doi:10.1002/med.21743 · Cited by 347
Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders
Radad, K., Gille, G., Liu, L., & Rausch, W. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05010x · Cited by 268
Herbal medicine for sports: a review
Sellami, M., Slimeni, O., Pokrywka, A., Kuvačić, G., Hayes, L. D., Milić, M., & Padulo, J. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0218-y · Cited by 189
Metadata
- Authors
- Nocerino, E., Amato, M., & Izzo, A. A.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Izzo, Angelo A
- ORCID
- Izzo, Angelo A
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 71
- Pages
- S1-S5
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2150490050
- Cited by
- 229
- References
- 26
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 15 · 2015: 7 · 2014: 9 · 2013: 16 · 2012: 18
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- ginseng, Panax quinquefolius, Panax ginseng, ginsenosides, triterpenoid saponins, aphrodisiac effect, adaptogenic properties, hypothalamic-pituitary-adrenal axis, corticosteroids, stress tolerance, aging, sexual performance, adverse effects, safety
- MeSH terms
- Aphrodisiacs, Drugs, Chinese Herbal, Panax, Humans, Phytotherapy, Plant Roots
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review