Cited by 232Ginseng Biological Effects and ApplicationsMedicinal Plants and Bioactive CompoundsTraditional Chinese Medicine Analysis

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

The aphrodisiac and adaptogenic properties of ginseng

Nocerino, Emilia, Amato, Marianna, Izzo, Angelo A·2000·Fitoterapia

DOI 10.1016/s0367-326x(00)00170-2

Open this paper in CoChat — free account

Abstract

Ginseng is the root of the perennial herbs of Panax quinquefolium and Panax ginseng which contain a series of tetracyclic triterpenoid saponins (ginsenosides) as active ingredients. It is considered a tonic or adaptogenic that enhances physical performance (including sexual), promotes vitality and increases resistance to stress and ageing. The adaptogenic properties of ginseng are believed to be due to its effects on hypothalamic-pituitary-adrenal axis, resulting in elevated plasma corticotropin and corticosteroids levels. When used appropriately, ginseng appears to be safe. Nevertheless, documented side effects include hypertension, diarrhoea, restlessness, mastalgia and vaginal bleeding.

Integrity signals

Registry

Crossref · 10.1016/s0367-326x(00)00170-2

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

New Substances of Plant Origin Which Increase Nonspecific Resistance
Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595
Panax ginseng pharmacology: A nitric oxide link?
Gillis, C. N. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00193-7 · Cited by 568
A Review of 12 Commonly Used Medicinal Herbs
Ohara, M. (1998) · Archives of Family Medicine · doi:10.1001/archfami.7.6.523 · Cited by 476
Ginseng abuse syndrome. Problems with the panacea
Siegel, R. (1979) · JAMA · doi:10.1001/jama.241.15.1614 · Cited by 269
Herbal Remedies in Psychiatric Practice
Wong, A. H. C., Smith, M. T., & Boon, H. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.1033 · Cited by 231
CARDIOVASCULAR PROTECTION BY GINSENOSIDES AND THEIR NITRIC OXIDE RELEASING ACTION
Chen, X. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb01767.x · Cited by 203
Ginseng Abuse Syndrome
Siegel, R. K. (1979) · JAMA · doi:10.1001/jama.1979.03290410046024 · Cited by 192
Drugs Of Natural Origin
Samuelsson, G. (1992) · Cited by 155
A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers
D’Angelo, L., Grimaldi, R., Caravaggi, M., Marcoli, M., Perucca, E., Lecchini, S., Frigo, G. M., & Crema, A. (1986) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(86)90063-2 · Cited by 146
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00003 · Cited by 143

Show all 26 references

Research works printed but not linked: 7

Shibata, 1985, Econ Med Plant Res, 1, 217
Sonnerborn, 1991, Br J Phytother, 2, 3
Pieralisi, 1991, Clin Ther, 13, 373
Choi, 1995, Int J Impot Res, 7, 181
Guodong, 1987, Chin J Integr Trad West Med, 7, 326
Yushu, 1988, J Trad Chin Med, 8, 293
Nakagawa, 1985, Hiroshima J Med Sci, 34, 303

Sorted by citations

Biological activities and distribution of plant saponins
Sparg, S. G., Light, M. E., & van Staden, J. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.05.016 · Cited by 1,469
Neuroprotective potential of phytochemicals
Kumar, G., & Khanum, F. (2012) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.99898 · Cited by 526
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress and aging related diseases
Panossian, A. G., Efferth, T., Shikov, A. N., Pozharitskaya, O. N., Kuchta, K., Mukherjee, P. K., Banerjee, S., Heinrich, M., Wu, W., Guo, D., et al. (2021) · Medicinal Research Reviews · doi:10.1002/med.21743 · Cited by 347
Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders
Radad, K., Gille, G., Liu, L., & Rausch, W. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05010x · Cited by 268
Herbal medicine for sports: a review
Sellami, M., Slimeni, O., Pokrywka, A., Kuvačić, G., Hayes, L. D., Milić, M., & Padulo, J. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0218-y · Cited by 189
Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets
Iriti, M., Vitalini, S., Fico, G., & Faoro, F. (2010) · Molecules · doi:10.3390/molecules15053517 · Cited by 191
Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
Han, L.-K., Zheng, Y., Yoshikawa, M., Okuda, H., & Kimura, Y. (2005) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-5-9 · Cited by 179
Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men
Gonzales, G. F., Cordova, A., Vega, K., Chung, A., Villena, A., & Gonez, C. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1760163 · Cited by 178
Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men
Gonzales, G. F., Cordova, A., Vega, K., Chung, A., Villena, A., Gonez, C., & Castillo, S. (2002) · Andrologia · doi:10.1046/j.1439-0272.2002.00519.x · Cited by 177
Herbal Processing and Extraction Technologies
Azmin, S. N. H. M., Manan, Z. A., Alwi, S. R. W., Chua, L. S., Mustaffa, A. A., & Yunus, N. A. (2016) · Separation and Purification Reviews · doi:10.1080/15422119.2016.1145395 · Cited by 169
Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects
Metwaly, A. M., Zhu, L., Luqi, H., & Deqiang, D. (2019) · Molecules · doi:10.3390/molecules24101856 · Cited by 144
DNA barcodes for everyday life: Routine authentication of Natural Health Products
Wallace, L. J., Boilard, S., Eagle, S. H. C., Spall, J. L., Shokralla, S., & Hajibabaei, M. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.048 · Cited by 146
Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell
Park, E. H., Kim, Y., Yamabe, N., Park, S.-H., Kim, H.-K., Jang, H.-J., Kim, J. H., Cheon, G. J., Ham, J., & Kang, K. S. (2014) · Journal of Ginseng Research · doi:10.1016/j.jgr.2013.11.007 · Cited by 143
Ginseng leaf-stem: bioactive constituents and pharmacological functions
Wang, H., Peng, D., & Xie, J. (2009) · Chinese Medicine · doi:10.1186/1749-8546-4-20 · Cited by 143
Ginsenoside Rb1 as a neuroprotective agent: A review
Ahmed, T., Raza, S. H., Maryam, A., Setzer, W. N., Braidy, N., Nabavi, S. F., de Oliveira, M. R., & Nabavi, S. M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.002 · Cited by 142
Adaptogenic effect of Bacopa monniera (Brahmi)
Rai, D., Bhatia, G., Palit, G., Pal, R., Singh, S., & Singh, H. K. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00156-4 · Cited by 140
Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives
Huang, X., Li, N., Pu, Y., Zhang, T., & Wang, B. (2019) · Molecules · doi:10.3390/molecules24162939 · Cited by 138
Anti-stress Effects of Ginkgo biloba and Panax ginseng: a Comparative Study
Rai, D., Bhatia, G., Sen, T., & Palit, G. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.458 · Cited by 134
Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs
Malík, M., & Tlustoš, P. (2022) · Nutrients · doi:10.3390/nu14163367 · Cited by 127
Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
Akkol, E. K., Çankaya, İ. İ. T., Karatoprak, G. Ş., Çarpar, E., Sobarzo‐Sánchez, E., & Capasso, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.669638 · Cited by 128
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121
Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?: Treatment of hypogonadism with Tongkat ali
Tambi, M. I. B. M., Imran, M. K., & Henkel, R. R. (2012) · Andrologia · doi:10.1111/j.1439-0272.2011.01168.x · Cited by 120
Male Sexual Dysfunction and Methods used in Assessing Medicinal Plants with Aphrodisiac Potentials
Yakubu, M., Akanji, M., & Oladiji, A. (2007) · Cited by 117
Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-β1-induced epithelial–mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance
Kim, Y., Choi, W., Jeon, B., Choi, K., Kim, K., Kim, T., Ham, J., Jang, H. J., Kang, K. S., & Ko, H. (2014) · Toxicology · doi:10.1016/j.tox.2014.04.002 · Cited by 113
Neuroprotective effects of ginsenosides
Rausch, W., Liu, S., Gille, G., & Radad, A. (2006) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2006-1625 · Cited by 104
Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: In Vitro and Animal Study
Lee, H.-S., Kim, M.-R., Park, Y., Park, H. J., Chang, U. J., Kim, S. Y., & Suh, H. J. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2187 · Cited by 101
Ginsenosides and Their CNS Targets
Radad, K., Moldzio, R., & Rausch, W. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00208.x · Cited by 98
Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs
Kumar, G. P., Anilakumar, K. R., & Naveen, S. (2015) · Pharmacognosy Journal · doi:10.5530/pj.2015.1.1 · Cited by 94
Thymoquinone protects dopaminergic neurons against MPP+ and rotenone
Radad, K., Moldzio, R., Taha, M., & Rausch, W. (2008) · Phytotherapy Research · doi:10.1002/ptr.2708 · Cited by 88
Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation
Kang, K. S., Yamabe, N., Kim, H. Y., Okamoto, T., Sei, Y., & Yokozawa, T. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.05.027 · Cited by 87
Review on Labisia pumila (Kacip Fatimah): Bioactive phytochemicals and skin collagen synthesis promoting herb
Chua, L. S., Lee, S. Y., Abdullah, N., & Sarmidi, M. R. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.04.002 · Cited by 88
Aphrodisiac properties of Allium tuberosum seeds extract
Guohua, H., Lü, Y., Rengang, M., Dong-zhi, W., Ma, Z., & Hua, Z. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.01.018 · Cited by 84
Rise of Herbal and Traditional Medicine in Erectile Dysfunction Management
Ho, C. C. K., & Tan, H. M. (2011) · Current Urology Reports · doi:10.1007/s11934-011-0217-x · Cited by 82
Natural Aphrodisiacs
Shamloul, R. M. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01521.x · Cited by 82
Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions
Irfan, M., Kwak, Y.-S., Han, C.-K., Hyun, S. H., & Rhee, M. H. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.03.001 · Cited by 81
Nutrients and botanicals for erectile dysfunction: examining the evidence.
McKay, D. (2004) · PubMed · Cited by 81
Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in lung cancer
Kim, H., Choi, P., Kim, T., Kim, Y.-S., Song, B. G., Park, Y., Choi, S.-J., Yoon, C. H., Lim, W., Ko, H., et al. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.02.005 · Cited by 77
Inhibition of inflammations and macrophage activation by ginsenoside-Re isolated from Korean ginseng (Panax ginseng C.A. Meyer)
Paul, S., Shin, H. S., & Kang, S. C. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.035 · Cited by 71
Actoprotective effect of ginseng: improving mental and physical performance
Oliynyk, S., & Oh, S. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.144 · Cited by 64
Korean Red Ginseng Slows Depletion of CD4 T Cells in Human Immunodeficiency Virus Type 1-Infected Patients
Sung, H., Kang, S., Lee, M.-S., Kim, T. G., & Cho, Y.-K. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.4.497-501.2005 · Cited by 62
Plant-derived nanovesicles: Promising therapeutics and drug delivery nanoplatforms for brain disorders
Wang, R., Zhang, Y., Guo, Y., Zeng, W., Li, J., Wu, J. J., Li, N., Zhu, A., Li, J., Di, L., et al. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.09.007 · Cited by 60
Veterinary Herbal Medicine: A Systems-Based Approach
Wynn, S. G., & Fougère, B. J. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-02998-8.50024-x · Cited by 59
Comparative Analysis of the Rats’ Gut Microbiota Composition in Animals with Different Ginsenosides Metabolizing Activity
Dong, W., Xuan, F.-L., Zhong, F., Jiang, J., Wu, S., Li, D., & Quan, L. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04848 · Cited by 59
Therapeutic Effects of Fermented Red Ginseng in Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study
Jung, J., Kang, H., Ji, G. E., Park, M.-S., Song, W., Kim, M., Kwon, J., Kim, T.-W., Park, H., Cho, S., et al. (2011) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2011.3.2.103 · Cited by 58
Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56
Subacute Oral Toxicity Study of Korean Red Ginseng Extract in Sprague-Dawley Rats
Park, S., Lim, K.-H., Noh, J.-H., Jeong, E. J., Kim, Y.-S., Han, B.-C., Lee, S., & Moon, K. (2013) · Toxicological Research · doi:10.5487/tr.2013.29.4.285 · Cited by 54
A current status of adaptogens: Natural remedy to stress
Pawar, V. S., & Shivakumar, H. (2012) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(12)60207-2 · Cited by 52
Antioxidant Activity of Panax ginseng to Regulate ROS in Various Chronic Diseases
Morshed, M. N., Ahn, J. C., Mathiyalagan, R., Rupa, E. J., Akter, R., Karim, M. R., Jung, D.-H., Yang, D. U., Yang, D., & Jung, S. K. (2023) · Applied Sciences · doi:10.3390/app13052893 · Cited by 53
Chemical constituents and biological activities of the berry of Panax ginseng
Lee, S., Kim, Y. K., Park, N. I., Kim, C. S., Lee, C., & Park., S. U. (2010) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000356 · Cited by 50
Fluoride Exposure Aggravates the Testicular Damage and Sperm Quality in Diabetic Mice: Protective Role of Ginseng and Banaba
Saumya, S. M., & Basha, P. M. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0893-y · Cited by 49
Effects of Red and Fermented Ginseng and Ginsenosides on Allergic Disorders
Han, M. J., & Kim, D. (2020) · Biomolecules · doi:10.3390/biom10040634 · Cited by 46
Nondestructive Differentiation of Panax Species Using Visible and Shortwave Near-Infrared Spectroscopy
Chen, X., Wu, D., He, Y., & Shou, L. (2009) · Food and Bioprocess Technology · doi:10.1007/s11947-009-0199-6 · Cited by 45
Using reverse docking to identify potential targets for ginsenosides
Park, K. C., & Cho, A. E. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.10.005 · Cited by 45
Red Ginseng Supplementation More Effectively Alleviates Psychological than Physical Fatigue
Choi, J., Woo, T. S., Yoon, S.-Y., Peña, I. C. D., Choi, Y., Ahn, H. S., Lee, Y. S., Yu, G.-Y., & Cheong, J.-H. (2011) · Journal of Ginseng Research · doi:10.5142/jgr.2011.35.3.331 · Cited by 45
Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
Panossian, A., & Efferth, T. (2022) · Pharmaceuticals · doi:10.3390/ph15091051 · Cited by 49
Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future
Guan, W., & Wang, Q. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154938 · Cited by 43
Efficacy and safety of traditional Chinese medicine for cancer-related fatigue: a systematic literature review of randomized controlled trials
Yang, J., Li, Y., Chau, C. I., Shi, J., Chen, X., Hu, H., & Ung, C. O. L. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00849-y · Cited by 41
Beneficial effects of american ginseng on epididymal sperm analyses in cyclophosphamide treated rats.
Hosseini, A., Pakdel, F. G., Ahmadi, A., & Zare, S. (2012) · Europe PMC (PubMed Central) · Cited by 41
Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach
Kim, M., Kim, Y., Jeon, J., & Kim, D. S. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13080 · Cited by 36
Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities
Singh, A. P. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/259 · Cited by 36
Metabolism of Ginsenosides to Bioactive Compounds by Intestinal Microflora and Its Industrial Application
Kim, D.-H. (2009) · Journal of Ginseng Research · doi:10.5142/jgr.2009.33.3.165 · Cited by 34
Growth kinetics and ginsenosides production in transformed hairy roots of American ginseng—Panax quinquefolium L
Mathur, A., Gangwar, A., Mathur, A. K., Verma, P., Uniyal, G. C., & Lal, R. K. (2009) · Biotechnology Letters · doi:10.1007/s10529-009-0158-3 · Cited by 34
Anthocyanin production in a callus line of Panax sikkimensis Ban
Mathur, A., Mathur, A. K., Gangwar, A., Yadav, S., Verma, P., & Sangwan, R. S. (2009) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-009-9253-3 · Cited by 34
Anti-stress effects of ginseng total saponins on hindlimb-unloaded rats assessed by a metabolomics study
Li, F., Liu, X., Cao, F., Wang, L.-S., Chen, Y., Pan, R., Liao, Y., Wang, Q., & Chang, Q. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.04.028 · Cited by 34
Effect of sun ginseng methanol extract on lipopolysaccharide-induced liver injury in rats
Kang, K. S., Yamabe, N., Kim, H. Y., & Yokozawa, T. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.01.002 · Cited by 33
Traditional Plant Aphrodisiacs and Male Sexual Dysfunction
Bella, A. J., & Shamloul, R. M. (2013) · Phytotherapy Research · doi:10.1002/ptr.5074 · Cited by 33
Subchronic oral toxicity study of Korean red ginseng extract in Sprague-Dawley rats with a 4-week recovery period
Park, S., Noh, J.-H., Jeong, E. J., Kim, Y.-S., Han, B.-C., Lee, S., & Moon, K. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.11.007 · Cited by 30
Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases
Jakaria, M., Kim, J.-S., Karthivashan, G., Park, S., Ganesan, P., & Choi, D. (2018) · Journal of Ginseng Research · doi:10.1016/j.jgr.2018.01.001 · Cited by 30
Effects of andrographolide on sexual functions, vascular reactivity and serum testosterone level in rodents
Sattayasai, J., Srisuwan, S., Arkaravichien, T., & Aromdee, C. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.04.037 · Cited by 29
Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism
Gonzales, E. L., Jang, J., Mabunga, D. F. N., Kim, J., Ko, M. J., Cho, K. S., Bahn, G. H., Hong, M., Ryu, J. H., Kim, H. J., et al. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.29245 · Cited by 29
Ginseng treatment improves the sexual side effects of methadone maintenance treatment
Farnia, V., Alikhani, M., Ebrahimi, A., Golshani, S., Bahmani, D. S., & Brand, S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.05.004 · Cited by 29
Menometrorrhagia and Tachyarrhythmia after Using Oral and Topical Ginseng
Kabalak, A. A., Soyal, Ö. B., Urfalıoğlu, A., Saraçoğlu, F., & Göğüş, N. (2004) · Journal of Women s Health · doi:10.1089/jwh.2004.13.830 · Cited by 29
Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics
Panossian, A. G., Abdelfatah, S., & Efferth, T. (2021) · Pharmaceuticals · doi:10.3390/ph14101010 · Cited by 28
Production of ginsenoside and polysaccharide by two-stage cultivation of Panax quinquefolium L. cells
Wang, J., Gao, W., Zhang, J., Zuo, B., Zhang, L., & Huang, L. (2011) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-011-9396-x · Cited by 28
Use of complementary and alternative medicines for menopausal symptoms in Australian women aged 40–65 years
Gartoulla, P., Davis, S. R., Worsley, R., & Bell, R. J. (2015) · The Medical Journal of Australia · doi:10.5694/mja14.01723 · Cited by 28
The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications
Luo, B.-Y., Jiang, J., Fang, Y.-F., Yang, F., Yin, M.-D., Zhang, B.-C., Zhao, R., & Shao, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105031 · Cited by 28
Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration
Kim, U., Park, M. H., Kim, D., & Yoo, H. H. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.09.050 · Cited by 27
Effect of Eurycoma longifolia Jack (Tongkat ali) extract on human spermatozoa in vitro
Erasmus, N., Solomon, M. C., Fortuin, K. A., & Henkel, R. (2012) · Andrologia · doi:10.1111/j.1439-0272.2012.01282.x · Cited by 27
A Review of the Different Methods Applied in Ginsenoside Extraction From Panax ginseng and Panax quinquefolius Roots
Jegal, J., Jeong, E. J., & Yang, M. H. (2019) · Natural Product Communications · doi:10.1177/1934578x19868393 · Cited by 26
Korean red ginseng extract does not cause embryo‐fetal death or abnormalities in mice
Shin, S., Jang, J. Y., Park, D., Yon, J., Baek, I., Hwang, B. Y., Nam, S., Yun, Y. W., Kim, K., Joo, S. S., et al. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20224 · Cited by 26
Differential morphogenetic responses, ginsenoside metabolism and RAPD patterns of three Panax species
Mathur, A., Mathur, A. K., Sangwan, R. S., Gangwar, A., & Uniyal, G. C. (2003) · Genetic Resources and Crop Evolution · doi:10.1023/a:1023534927337 · Cited by 26
The Potential of Minor Ginsenosides Isolated from the Leaves of Panax ginseng as Inhibitors of Melanogenesis
Lee, D., Cha, B., Lee, Y., Kim, G., Noh, H.-J., Kim, S.-Y., Kang, H. K., Kim, J., & Baek, N. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011677 · Cited by 25
Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through the Akt/GSK3β signaling pathway in human cervical cancer cells
Shi, X., Yang, J. H., & Wei, G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8454 · Cited by 25
Ginseng Total Saponins Reverse Corticosterone‐Induced Changes in Depression‐Like Behavior and Hippocampal Plasticity‐Related Proteins by Interfering with GSK‐3β‐CREB Signaling Pathway
Chen, L., Dai, J., Wang, Z., Zhang, H., Huang, Y.-F., & Zhao, Y. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/506735 · Cited by 24
Quality changes of ready-to-eat ginseng chicken porridge during storage at 25°C
Jang, D. H., & Lee, K. T. (2012) · Meat Science · doi:10.1016/j.meatsci.2012.05.013 · Cited by 24
Metabolite profiling of ginsenosides in rat plasma, urine and feces by LC–MS/MS and its application to a pharmacokinetic study after oral administration of Panax ginseng extract
Dong, W., Han, X., Zhao, J., Zhong, F., Ma, R., Wu, S., Li, D., Quan, L., & Jiang, J. (2017) · Biomedical Chromatography · doi:10.1002/bmc.4105 · Cited by 23
Factors influencing cultivated ginseng (Panax ginseng C. A. Meyer) bioactive compounds
Yu, H., Zhao, J., You, J., Li, J., Ma, H., & Chen, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223763 · Cited by 23
Optimization and quality assessment of adventitious roots culture in Panax quinquefolium L.
Liu, H., Wang, J., Gao, W., Wang, Q., Zhang, L., & Man, S. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1449-9 · Cited by 22
Korean red ginseng protects against doxorubicin-induced testicular damage: An experimental study in rats
Kopalli, S. R., Won, Y.-J., Hwang, S., Cha, K.-M., Kim, S.-Y., Han, C.-K., Lee, S., Hong, J.-Y., & Kim, S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.020 · Cited by 22
Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses
Cha, K.-M., Kopalli, S. R., Han, S. Y., Lee, S.-H., Jeong, M.-S., Cho, J. Y., Han, C.-G., Lee, S., Kim, S.-N., Kim, J.-C., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.008 · Cited by 21
Ginseng (Panax sp.) proteomics: an update
Kim, S. W., Lee, S. H., Min, C. W., Jo, I. H., Bang, K. H., Hyun, D.-Y., Agrawal, G. K., Rakwal, R., Zargar, S. M., Gupta, R., et al. (2017) · Applied Biological Chemistry · doi:10.1007/s13765-017-0283-y · Cited by 21
Erectile dysfunction: A review and herbs used for its treatment
Saxena, A. K., Prakash, P., Sissodia, N., Sharma, P., & Porwal, M. (2012) · International Journal of Green Pharmacy · doi:10.4103/0973-8258.102825 · Cited by 21
Isolation and Quantification of Ginsenoside Rh23, a New Anti-Melanogenic Compound from the Leaves of Panax ginseng
Lee, D., Kim, H., Lee, Y., Kim, J., Lee, J. W., Choi, B. R., Jang, I., Kim, G., & Baek, N. (2018) · Molecules · doi:10.3390/molecules23020267 · Cited by 21
Effect of Korean Red Ginseng on radiation-induced bone loss in C3H/HeN mice
Lee, J.-H., Lee, H., Yang, M., Moon, C., Kim, J.-C., Bae, C., Jo, S., Jang, J., & Kim, S. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.435 · Cited by 20
Study of the neuroprotective effect of ginseng on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in experimental diffuse head trauma
Demır, İ., Kıymaz, N., Güdü, B. O., Türköz, Y., Gül, M., Doğan, Z., & Demirtaş, S. (2013) · Acta Neurochirurgica · doi:10.1007/s00701-013-1672-6 · Cited by 19
UPLC-QTOFMS based metabolomics followed by stepwise partial least square-discriminant analysis (PLS-DA) explore the possible relation between the variations in secondary metabolites and the phylogenetic divergences of the genus Panax
Nguyen, H. T., Lee, D., Lee, W. J., Lee, G., Yoon, S. J., Shin, B.-K., Nguyen, M. D., Park, J. H., Lee, J., & Kwon, S. W. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.01.002 · Cited by 21
Nanocarriers in the Enhancement of Therapeutic Efficacy of Natural Drugs
Li, X., Liang, S., Tan, C. H., Cao, S., Xu, X., Saw, P. E., & Tao, W. (2021) · BIO Integration · doi:10.15212/bioi-2020-0040 · Cited by 19
American ginseng tea protects cellular DNA within 2 h from consumption: results of a pilot study in healthy human volunteers
Szeto, Y. T., Sin, Y. S. P., Pak, S. C., & Kalle, W. H. J. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1088937 · Cited by 19
Korean Red Ginseng Significantly Slows CD4 T Cell Depletion over 10 Years in HIV-1 Infected Patients: Association with HLA
(2004) · Journal of Ginseng Research · doi:10.5142/jgr.2004.28.4.173 · Cited by 18
Comparing Ginsenoside Production in Leaves and Roots of Wild American Ginseng (Panax quinquefolius)
Searels, J. M., Keen, K. D., Horton, J. L., Clarke, H. D., & Ward, J. R. (2013) · American Journal of Plant Sciences · doi:10.4236/ajps.2013.46154 · Cited by 17

Authors: Nocerino, E., Amato, M., & Izzo, A. A.
Affiliations: University of Naples Federico II (IT)
Corresponding author: Izzo, Angelo A
ORCID: Izzo, Angelo A
Venue: Fitoterapia
Publisher: Elsevier BV
Published: 2000-08
Volume: 71
Pages: S1-S5
ISSN: 0367-326X (ISSN-L)
DOI: 10.1016/s0367-326x(00)00170-2
OpenAlex: W2150490050
Cited by: 229
References: 26
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 15 · 2015: 7 · 2014: 9 · 2013: 16 · 2012: 18
FWCI: 0.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fitoterapia (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginseng Biological Effects and Applications
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
Keywords: ginseng, Panax quinquefolius, Panax ginseng, ginsenosides, triterpenoid saponins, aphrodisiac effect, adaptogenic properties, hypothalamic-pituitary-adrenal axis, corticosteroids, stress tolerance, aging, sexual performance, adverse effects, safety
MeSH terms: Aphrodisiacs, Drugs, Chinese Herbal, Panax, Humans, Phytotherapy, Plant Roots

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The aphrodisiac and adaptogenic properties of ginseng

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks