Treatment of opioid-dependent pregnant women: Clinical and research issues
Open accessAbstract
This article addresses common questions that clinicians face when treating pregnant women with opioid dependence. Guidance, based on both research evidence and the collective clinical experience of the authors, which include investigators in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) project, is provided to aid clinical decision making. The MOTHER project is a double-blind, double-dummy, flexible-dosing, parallel-group clinical trial examining the comparative safety and efficacy of methadone and buprenorphine for the treatment of opioid dependence in pregnant women and their neonates. The article begins with a discussion of appropriate assessment during pregnancy and then addresses clinical management stages including maintenance medication selection, induction, and stabilization; opioid agonist medication management before, during, and after delivery; pain management; breast-feeding; and transfer to aftercare. Lastly, other important clinical issues including managing co-occurring psychiatric disorders and medication interactions are discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Current standard of care for treatment of opioid use disorder is medication treatment, most often with methadone or buprenorphine.
“Current standard of care for treatment of OUD is medication treatment, most often with methadone or buprenorphine [1].”
From Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder (2025) · cites this paper as [1]
Section 3 (page unavailable) identifies methadone as the standard of care for opioid-dependent patients entering treatment during pregnancy. The paper discusses buprenorphine as a treatment option, but says methadone was the only medication recommended for pregnant patients at the time. It does not establish the broader claim about current treatment of OUD generally or present both medications as standard options in pregnancy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Fifth Edition of the Addiction Severity Index.
Mclellan, A., Kushner, H., Metzger, D., Peters, R., Smith, I. E., Grissom, G. R., Pettinati, H., & Argeriou, M. (1992) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(92)90062-s · Cited by 4,279 · see citing works
Yu, S. M. (1998) · Maternal and Child Health Journal · doi:10.1023/a:1021801927353 · Cited by 3,876 · see citing works
Lumeij, J. T. (1997) · Elsevier eBooks · doi:10.1016/b978-012396305-5/50031-2 · Cited by 1,185 · see citing works
The Clinical Opiate Withdrawal Scale (COWS)
Wesson, D. R., & Ling, W. W. (2003) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2003.10400007 · Cited by 1,120 · see citing works
Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn
Chambers, C., Hernández–Dı́az, S., Marter, L. J. V., Werler, M. M., Louik, C., Jones, K. L., & Mitchell, A. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052744 · Cited by 877 · see citing works
A meta-analysis of voucher-based reinforcement therapy for substance use disorders
Lussier, J. P., Heil, S. H., Mongeon, J. A., Badger, G. J., & Higgins, S. T. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01311.x · Cited by 858 · see citing works
Self-citationMechanisms of fatal opioid overdose
White, J. M., & Irvine, R. J. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9479612.x · Cited by 635 · see citing works
Eap, C. B., Buclin, T., & Baumann, P. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241140-00003 · Cited by 599 · see citing works
Effective Medical Treatment of Opiate Addiction
Addiction, N. C. D. P. O. E. M. T. O. O. (1998) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.280.22.1936 · Cited by 577 · see citing works
Perinatal Risks of Untreated Depression during Pregnancy
Bonari, L., Pinto, N., Ahn, E., Einarson, A., Steiner, M. S., & Koren, G. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901103 · Cited by 524 · see citing works
Acute Pain Management for Patients Receiving Maintenance Methadone or Buprenorphine Therapy
Alford, D. P., Compton, P. A., & Samet, J. H. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-2-200601170-00010 · Cited by 465 · see citing works
Textbook of Substance Abuse Treatment
Seelye, E. E. (1995) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1995.49.2.300 · Cited by 386 · see citing works
Jones, H. E., Johnson, R. E., Jasinski, D. R., O’Grady, K. E., Chisholm, C. A., Choo, R. E., Crocetti, M. T., Dudas, R. A., Harrow, C., Huestis, M. A., et al. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.013 · Cited by 294 · see citing works
Self-citationRawson, R. A., Huber, A., McCann, M., SHOPTAW, S. J., Farabee, D. J., Reiber, C., & Ling, W. W. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.817 · Cited by 290 · see citing works
OPIOID DEPENDENCE DURING PREGNANCY
Kaltenbach, K. A., Berghella, V., & Finnegan, L. P. (1998) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70362-4 · Cited by 282 · see citing works
Self-citationAbuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine.
Henningfield, J. E., Miyasato, K., & Jasinski, D. R. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23319-5 · Cited by 281 · see citing works
In utero antiepileptic drug exposure
Meador, K. J., Baker, G. A., Finnell, R. H., Kalayjian, L. A., Liporace, J. D., Loring, D. W., Mawer, G. E., Pennell, P. B., Clayton‐Smith, J., & Wolff, M. (2006) · Neurology · doi:10.1212/01.wnl.0000227919.81208.b2 · Cited by 277 · see citing works
Abdel-Latif, M. E., Pinner, J., Clews, S., Cooke, F., Lui, K., & Oei, J. (2006) · Pediatrics · doi:10.1542/peds.2005-1561 · Cited by 266 · cited 1× · see citing works
“Although the overall amount of methadone in breast milk appears to be low, ranging from 21 to 314 ng/ml, and not related to maternal methadone dose (Jansson, Dipietro, Elko, & Velez, 2007), ingesting breast milk relative to formula has been found to be associated with less severe NAS (Abdel-Latif et al., 2006).”
BackgroundUse of buprenorphine in pregnancy: patient management and effects on the neonate
Johnson, R. E. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00062-0 · Cited by 243 · see citing works
Lejeune, C., Simmat-Durand, L., Gourarier, L., & Aubisson, S. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.10.001 · Cited by 237 · see citing works
Methadone versus buprenorphine in pregnant addicts: a double‐blind, double‐dummy comparison study
Fischer, G., Ortner, R., Rohrmeister, K., Jagsch, R., Baewert, A., Langer, M., & Aschauer, H. N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01321.x · Cited by 235 · see citing works
Self-citationClinical guide to alcohol treatment: The Community reinforcement approach
Hertzman, M. (1996) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(96)00047-5 · Cited by 229 · see citing works
Carroll, K. M., Easton, C. J., Nich, C., Hunkele, K. A., Neavins, T. M., Sinha, R., Ford, H. L., Vitolo, S. A., Doebrick, C. A., & Rounsaville, B. J. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.5.955 · Cited by 214 · see citing works
Short-term effects of early suckling and touch of the nipple on maternal behaviour
Widström, A.-M., Wahlberg, V., MATTHIESEN, A. ‐., Eneroth, P. H. E., Uvnäs‐Moberg, K., Werner, S., & Winberg, J. (1990) · Early Human Development · doi:10.1016/0378-3782(90)90114-x · Cited by 207 · see citing works
Cohen, R., Mrtek, M. B., & Mrtek, R. G. (1995) · American Journal of Health Promotion · doi:10.4278/0890-1171-10.2.148 · Cited by 193 · see citing works
Altered methadone pharmacokinetics in methadone-maintained pregnant women.
Pond, S. M., Kreek, M. J., Tong, T. G., Raghunath, J., & Benowitz, N. L. (1985) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21130-2 · Cited by 189 · see citing works
Pharmacokinetics of the combination tablet of buprenorphine and naloxone
CHIANG, C. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00058-9 · Cited by 181 · see citing works
The Community Reinforcement Approach
Meyers, R. J., Smith, J. E., & Lash, D. N. (2002) · Springer eBooks · doi:10.1007/0-306-47939-7_14 · Cited by 180 · see citing works
Methadone maintenance vs. methadone taper during pregnancy: maternal and neonatal outcomes.
Jones, H., O'Grady, K., Malfi, D., & Tuten, M. (2008) · American Journal on Addictions · doi:10.1080/10550490802266276 · Cited by 180 · see citing works
Self-citationDHHS Blueprint for Action on Breastfeeding
Satcher, D. S. (2001) · Public Health Reports · doi:10.1093/phr/116.1.72 · Cited by 167 · see citing works
The narcotic-dependent mother: Fetal and neonatal consequences
Kandall, S. R., Albin, S., Gartner, L. M., Lee, K., Eidelman, A. I., & Lowinson, J. H. (1977) · Early Human Development · doi:10.1016/0378-3782(77)90017-2 · Cited by 166 · see citing works
Pharmacotherapy for Cocaine-Abusing Methadone-Maintained Patients Using Amantadine or Desipramine
Kosten, T. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110058009 · Cited by 162 · see citing works
Treatment of opioid‐dependent pregnant women with buprenorphine
Fischer, G., Johnson, R. E., Eder, H., Jagsch, R., Peternell, A., Weninger, M., Langer, M., & Aschauer, H. N. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.95223910.x · Cited by 160 · see citing works
Self-citationGeorge, T. P., Chawarski, M. C., Pakes, J., Carroll, K. M., Kosten, T. R., & Schottenfeld, R. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00310-8 · Cited by 159 · see citing works
Wilson, G. S., Desmond, M. M., & Wait, R. B. (1981) · The Journal of Pediatrics · doi:10.1016/s0022-3476(81)80830-x · Cited by 157 · see citing works
Involvement of cytochrome P450 3A4 in N-dealkylation of buprenorphine in human liver microsomes
Iribarne, C., PICART, D., Dréano, Y., Bail, J. P., & Berthou, F. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00160-4 · Cited by 157 · see citing works
Fetal stress from methadone withdrawal
Zuspan, F. P., Gumpel, J. A., Mejia-Zelaya, A., Madden, J. D., & Davis, R. (1975) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(75)90613-4 · Cited by 156 · see citing works
Perinatal addiction: Outcome and management
Connaughton, J. F., Reeser, D. S., Schut, J., & Finnegan, L. P. (1977) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(77)90652-4 · Cited by 151 · see citing works
Six deaths linked to concomitant use of buprenorphine and benzodiazepines
Reynaud, M., Petit, G., Potard, D., & Courty, P. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.93913859.x · Cited by 146 · see citing works
Amass, L., Kamien, J. B., & Mikulich, S. K. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00074-5 · Cited by 136 · see citing works
Narcotic withdrawal in pregnancy: Stillbirth incidence with a case report
Rementería, J. L., & Nunag, N. N. (1973) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(73)90953-8 · Cited by 130 · see citing works
Estimating WAIS IQ from the shipley institute of living scale using continuously adjusted age norms
Zachary, R. A., Paulson, M. J., & Gorsuch, R. L. (1985) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198511)41:6 · Cited by 125 · see citing works
McCance‐Katz, E. F., Rainey, P. M., Friedland, G. H., & Jatlow, P. I. (2003) · Clinical Infectious Diseases · doi:10.1086/376907 · Cited by 125 · see citing works
Buprenorphine treatment of pregnant opioid-dependent women: maternal and neonatal outcomes
Johnson, R. E., Jones, H. E., Jasinski, D. R., Svikis, D. S., Haug, N. A., Jansson, L. M., Kissin, W. B., Alpan, G., Lantz, M. E., Cone, E. J., et al. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00194-0 · Cited by 125 · see citing works
Self-citationGreenwald, M., Johanson, C.-E., Bueller, J., Chang, Y., Moody, D. E., Kilbourn, M., Koeppe, R., & Zubieta, J.-K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.043 · Cited by 124 · see citing works
Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors.
Iribarne, C., Berthou, F., Carlhant, D., Dréano, Y., PICART, D., Dévéhat, F. L., & Riché, C. (1998) · PubMed · Cited by 123 · see citing works
Brunton, P. J., Meddle, S., Ma, S., Ochędalski, T., Douglas, A. J., & Russell, J. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0866-05.2005 · Cited by 120 · see citing works
Methadone Effects on Zidovudine Disposition (AIDS Clinical Trials Group 262)
McCance‐Katz, E. F., Rainey, P. M., Jatlow, P. I., & Friedland, G. H. (1998) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199808150-00004 · Cited by 113 · see citing works
A new series of 13 buprenorphine-related deaths
Kintz, P. (2002) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00304-1 · Cited by 112 · see citing works
Fetal response to maternal methadone administration
Jansson, L. M., DiPietro, J. A., & Elko, A. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.02.075 · Cited by 104 · see citing works
Mood disorders affect drug treatment success of drug-dependent pregnant women
Fitzsimons, H., Tuten, M., Vaidya, V. M., & Jones, H. E. (2006) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.06.015 · Cited by 97 · see citing works
Self-citationPretreatment dropout as a function of treatment delay and client variables
Festinger, D. S., Lamb, R. J., Kountz, M. R., Kirby, K. C., & Marlowe, D. B. (1995) · Addictive Behaviors · doi:10.1016/0306-4603(94)00052-z · Cited by 93 · see citing works
Haller, D. L., Knisely, J. S., Dawson, K. S., & Schnoll, S. H. (1993) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199308000-00006 · Cited by 93 · see citing works
Buprenorphine dosing every 1, 2, or 3 days in opioid-dependent patients
Bickel, W. K., Amass, L., Crean, J. P., & Badger, G. J. (1999) · Psychopharmacology · doi:10.1007/s002130051096 · Cited by 92 · see citing works
Alternate-day dosing during buprenorphine treatment of opioid dependence
Amass, L., Bickel, W. K., Higgins, S. T., & Badger, G. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00848-5 · Cited by 90 · see citing works
Intrapartum and Postpartum Analgesia for Women Maintained on Methadone During Pregnancy
Meyer, M. C., Wagner, K., Benvenuto, A., Plante, D., & Howard, D. B. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000275288.47258.e0 · Cited by 89 · see citing works
Assessment of Opioid Dependence with Naloxone
Peachey, J. E., & LEI, H. (1988) · British Journal of Addiction · doi:10.1111/j.1360-0443.1988.tb03981.x · Cited by 89 · see citing works
Stark, M. M., Campbell, B. B., & Brinkerhoff, C. (1990) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999009001573 · Cited by 88 · see citing works
Interaction between buprenorphine and atazanavir or atazanavir/ritonavir
McCance‐Katz, E. F., Moody, D. E., Morse, G. D., Ma, Q., DiFrancesco, R., Friedland, G. H., Pade, P., & Rainey, P. M. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.06.007 · Cited by 85 · see citing works
McCance‐Katz, E. F., Moody, D. E., Morse, G. D., FRIEDLAND, G. H., Pade, P., Baker, J., Alvanzo, A. A. H., Smith, P. F., Ogundele, A., Jatlow, P. I., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/508187 · Cited by 84 · see citing works
Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans.
Eissenberg, T., Greenwald, M. K., Johnson, R. E., Liebson, I. A., Bigelow, G. E., & Stitzer, M. L. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12294-5 · Cited by 79 · see citing works
Amass, L., Kamien, J. B., & Mikulich, S. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00141-1 · Cited by 79 · see citing works
Pregnancy in narcotics addicts treated by medical withdrawal
Blinick, G., Wallach, R. C., & Jerez, E. (1969) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(69)90117-3 · Cited by 78 · see citing works
Festinger, D. S., Lamb, R. J., Marlowe, D. B., & Kirby, K. C. (2002) · Addictive Behaviors · doi:10.1016/s0306-4603(01)00172-1 · Cited by 75 · see citing works
Modified Directly Observed Therapy (MDOT) for Injection Drug Users with HIV Disease
McCance‐Katz, E. F., Gourevitch, M. N., Arnsten, J. H., Sarlo, J. A., Rainey, P. M., & Jatlow, P. L. (2002) · American Journal on Addictions · doi:10.1080/10550490290088072 · Cited by 70 · see citing works
Methadone metabolism by human placenta
Nanovskaya, T. N., Deshmukh, S. V., Nekhayeva, I. A., Zharikova, O. L., Hankins, G. D. V., & Ahmed, M. S. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.011 · Cited by 70 · see citing works
Douglas, A. J., Meddle, S., Toschi, N., Bosch, O. J., & Neumann, I. D. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01272.x · Cited by 69 · see citing works
Cases of buprenorphine abuse in India
Singh, R., Mattoo, S. K., Malhotra, A. K., & Varma, V. K. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03224.x · Cited by 67 · see citing works
Alternate-day buprenorphine dosing is preferred to daily dosing by opioid-dependent humans
Amass, L., Bickel, W. K., Crean, J. P., Blake, J. E., & Higgins, S. T. (1998) · Psychopharmacology · doi:10.1007/s002130050559 · Cited by 67 · see citing works
Kreek, M. J., Schecter, A. J., Gutjahr, C. L., Bowen, D., Field, F. H., Queenan, J. T., & Merkatz, I. R. (1974) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952997409011033 · Cited by 66 · see citing works
Jansson, L. M., DiPietro, J. A., Elko, A., & Vélez, M. L. (2007) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701490327 · Cited by 65 · see citing works
Methadone disposition during the perinatal period in humans.
Mj, K. (1979) · PubMed · Cited by 64 · see citing works
Methadone trough levels in pregnancy
Drozdick, J., Berghella, V., Hill, M., & Kaltenbach, K. A. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.127132 · Cited by 60 · see citing works
Self-citationIn vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine
Iribarne, C., PICART, D., Dréano, Y., & Berthou, F. (1998) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1998.tb00941.x · Cited by 59 · see citing works
Effects of buprenorphine sublingual tablet maintenance on opioid drug-seeking behavior by humans
Greenwald, M. K., Schuh, K. J., Hopper, J. A., Schuster, C. R., & Johanson, C. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0975-0 · Cited by 59 · see citing works
The relationship between infant feeding method and maternal role adjustment
Virden, S. (1988) · Journal of Nurse-Midwifery · doi:10.1016/0091-2182(88)90246-7 · Cited by 59 · see citing works
Stasiewicz, P. R., & Stalker, R. (1999) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00082-3 · Cited by 58 · see citing works
Post‐Cesarean Pain Management of Patients Maintained on Methadone or Buprenorphine
Jones, H. E., Johnson, R. E., & Milio, L. A. (2006) · American Journal on Addictions · doi:10.1080/10550490600626721 · Cited by 57 · see citing works
Self-citationEffect of Opioid Dependence Pharmacotherapies on Zidovudine Disposition
McCance‐Katz, E. F., Rainey, P. M., Friedland, G. H., Kosten, T. R., & Jatlow, P. L. (2001) · American Journal on Addictions · doi:10.1111/j.1521-0391.2001.tb00519.x · Cited by 56 · see citing works
Methadone‐related deaths in Western Australia 1993–99
Ernst, E., Bartu, A. E., Popescu, A., Ilett, K. F., Hansson, R. C., & Plumley, N. (2002) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2002.tb00188.x · Cited by 55 · see citing works
Opioid antagonist challenges in buprenorphine maintained patients
Kosten, T. R., Krystal, J. H., Charney, D. S., Price, L. H., Morgan, C. H., & Kleber, H. D. (1990) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(90)90144-4 · Cited by 54 · see citing works
Comparison of Buprenorphine and Methadone Maintenance in Opiate Addicts
Eder, H., Fischer, G., Gombas, W., Jagsch, R., Stühlinger, G., & Kasper, S. F. (1998) · European Addiction Research · doi:10.1159/000052034 · Cited by 52 · see citing works
Self-citationIdentifying pregnant women at risk for early attrition from substance abuse treatment.
Kissin, W. B., Svikis, D., Moylan, P. L., Haug, N., & Stitzer, M. (2004) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2004.03.007 · Cited by 52 · see citing works
Handelsman, L., Stein, J. A., & Grella, C. E. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.03.022 · Cited by 52 · see citing works
Neonatal abstinence syndrome following abrupt cessation of breastfeeding.
Malpas, T. J., & Darlow, B. A. (1999) · PubMed · Cited by 51 · see citing works
Perinatal substance abuse: comments and perspectives.
Finnegan, L. P. (1991) · PubMed · Cited by 51 · see citing works
Buprenorphine Maintenance in Pregnant Opiate Addicts
Fischer, G., Etzersdorfer, P., Eder, H., Jagsch, R., Langer, M., & Weninger, M. (1998) · European Addiction Research · doi:10.1159/000052040 · Cited by 50 · see citing works
Self-citationJones, H. E., Johnson, R. E., Jasinski, D. R., & Milio, L. A. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.08.027 · Cited by 49 · see citing works
Self-citationWittmann, B. K., & Segal, S. (1991) · International Journal of the Addictions · doi:10.3109/10826089109053183 · Cited by 47 · see citing works
Friedland, G. H., Andrews, L., Schreibman, T., Agarwala, S., Daley, L., Child, M., Shi, J. M., Wang, Y., & O'Mara, E. M. (2005) · AIDS · doi:10.1097/01.aids.0000183628.20041.f2 · Cited by 46 · see citing works
Methadone—Disulfiram Interaction During Methadone Maintenance
Tong, T. G., Benowitz, N. L., & Kreek, M. J. (1980) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1980.tb02543.x · Cited by 46 · see citing works
Effect of buprenorphine on CYP3A activity in rat and human liver microsomes
Ibrahim, R. B., Wilson, J. G., Thorsby, M. E., & Edwards, D. J. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00436-7 · Cited by 45 · see citing works
THE ACCELERATED INTAKE: A METHOD FOR INCREASING INITIAL ATTENDANCE TO OUTPATIENT COCAINE TREATMENT
Festinger, D. S., Lamb, R. J., Kirby, K. C., & Marlowe, D. B. (1996) · Journal of Applied Behavior Analysis · doi:10.1901/jaba.1996.29-387 · Cited by 45 · see citing works
Diagnosis and Treatment of Depression During Pregnancy
Cohen, L. S., Nonacs, R. M., Viguera, A. C., & Reminick, A. M. (2004) · CNS Spectrums · doi:10.1017/s1092852900009007 · Cited by 42 · see citing works
Treatment of Pain in Pregnancy
Wunsch, M. J., Stanard, V., & Schnoll, S. H. (2003) · Clinical Journal of Pain · doi:10.1097/00002508-200305000-00002 · Cited by 42 · see citing works
Effect of Chronic Maternal Methadone Therapy on Intrapartum Fetal Heart Rate Patterns
Ramirez-Cacho, W. A., Flores, S., Schrader, R., McKay, J., & Rayburn, W. F. (2006) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2005.11.001 · Cited by 42 · see citing works
A Comparative Study of Postpartum Depression in Abused and Nonabused Women
Records, K., & Rice, M. J. (2005) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2005.07.010 · Cited by 41 · see citing works
Petry, N. M., Bickel, W. K., & Badger, G. J. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9668234.x · Cited by 41 · see citing works
Baker, J., Rainey, P. M., Moody, D. E., Morse, G. D., Ma, Q., & McCance‐Katz, E. F. (2009) · American Journal on Addictions · doi:10.1111/j.1521-0391.2009.00004.x · Cited by 40 · see citing works
Lack of Interaction of Buprenorphine With Flunitrazepam Metabolism
Kilicarslan, T., & Sellers, E. M. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1164 · Cited by 39 · see citing works
Precipitated withdrawal by pentazocine in methadone-maintained volunteers.
Strain, E. C., Preston, K. L., Liebson, I. A., & Bigelow, G. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39357-2 · Cited by 38 · see citing works
Fluoxetine Addition to Methadone in Addicts: Pharmacokinetic Aspects
Bertschy, G., Eap, C. B., Powell, K., & Baumann, P. (1996) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199610000-00008 · Cited by 36 · see citing works
Buprenorphine Therapy of Opiate Addiction
Kintz, P., & Marquet, P. P. (2002) · Humana Press eBooks · doi:10.1385/1592592821 · Cited by 34 · see citing works
Methadone Dosing and Pregnancy: Impact on Program Compliance
DePetrillo, P. B., & Rice, J.-M. (1995) · International Journal of the Addictions · doi:10.3109/10826089509060743 · Cited by 34 · see citing works
Assessing the needs of substance abusing women. Psychometric data on the psychosocial history.
Comfort, M., Zanis, D., Whiteley, M., Kelly-Tyler, A., & Kaltenbach, K. (1999) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(98)00048-8 · Cited by 33 · see citing works
Self-citationKetoconazole increases cocaine and opioid use in methadone maintained patients
Kosten, T. R., Oliveto, A. H., Sevarino, K. A., Gonsai, K., & Feingold, A. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00198-3 · Cited by 32 · see citing works
The effect of methadone and buprenorphine on human placental aromatase
Zharikova, O. L., Deshmukh, S. V., Nanovskaya, T. N., Hankins, G. D. V., & Ahmed, M. S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.035 · Cited by 29 · see citing works
Lack of Methadone Dose Alterations or Withdrawal Symptoms During Therapy With Lopinavir/Ritonavir
Stevens, R. C., Rapaport, S., Maroldo-Connelly, L., Patterson, J. B., & Bertz, R. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200308150-00016 · Cited by 28 · see citing works
Methadone induction doses: are our current practices safe?
Srivastava, A., & Kahan, M. (2006) · PubMed · doi:10.1300/j069v25n03_02 · Cited by 27 · see citing works
Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users
Oliveto, A. H., Kosten, T. R., Schottenfeld, R. S., Falcioni, J., & Ziedonis, D. M. (1995) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(95)02015-2 · Cited by 26 · see citing works
Petry, N. M., Bickel, W. K., & Badger, G. J. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.95710698.x · Cited by 25 · see citing works
A Therapeutic Use of the Methadone Fluvoxamine Drug Interaction
DeMaria, P. A., & Serota, R. D. (1999) · Journal of Addictive Diseases · doi:10.1300/j069v18n04_02 · Cited by 25 · see citing works
The effectiveness of drug treatment.
Dr, G. (1992) · PubMed · Cited by 24 · see citing works
Jones, H. E., Suess, P. E., Jasinski, D. R., & Johnson, R. E. (2006) · American Journal on Addictions · doi:10.1080/10550490500419094 · Cited by 23 · see citing works
Self-citation[Drug interactions with methadone].
Schlatter, J., Madras, J. L., Saulnier, J., & Poujade, F. (1999) · PubMed · Cited by 22 · see citing works
The effect of opiates on the activity of human placental aromatase/CYP19
Zharikova, O. L., Deshmukh, S. V., Kumar, M., Vargas, R., Nanovskaya, T. N., Hankins, G. D. V., & Ahmed, M. S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.019 · Cited by 21 · see citing works
Dosing Adjustments in Postpartum Patients Maintained on Buprenorphine or Methadone
Jones, H. E., Johnson, R. E., O’Grady, K. E., Jasinski, D. R., Tuten, M., & Milio, L. A. (2008) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e31815ca2c6 · Cited by 21 · see citing works
Self-citationEinarson, A., Selby, P. L., & Koren, G. (2001) · PubMed Central · Cited by 21 · see citing works
Self-citationTraining Primary Health Care Professionals to Prvide Buprenorphine and LAAM Treatment
Lintzeris, N., Ritter, A. J., Dunlop, A. J., & Muhleisen, P. (2002) · Substance Abuse · doi:10.1080/08897070209511497 · Cited by 19 · see citing works
Drug Addiction During Pregnancy
Jones, H. E. (2006) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2006.00421.x · Cited by 19 · see citing works
Self-citationKintz, P. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-282-1_8 · Cited by 17 · see citing works
Are the new SSRIs safe for pregnant women?
Kulin, N. A., Pastuszak, A. L., & Koren, G. (1998) · PubMed · Cited by 14 · see citing works
Detoxifikation polytoxikomaner Patienten mit Buprenorphin
Paetzold, W., Eronat, V., Seifert, J., Holze, I., Emrich, H. M., & Schneider, U. (2000) · Der Nervenarzt · doi:10.1007/s001150050656 · Cited by 10 · see citing works
Drug Interactions With Methadone in Humans
Kreek, M. J. (1986) · PsycEXTRA Dataset · doi:10.1037/e496852006-013 · Cited by 9 · see citing works
Depression in pregnant drug-dependent women.
Regan, D. O., Leifer, B., Matteucci, T., & Finnegan, L. P. (1982) · PsycEXTRA Dataset · doi:10.1037/e474622004-001 · Cited by 8 · see citing works
Intrapartum and Postpartum Analgesia for Women Maintained on Methadone During Pregnancy
Meyer, M. C., Wagner, K., Benvenuto, A., Plante, D. A., & Howard, D. B. (2008) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000319836.75469.8a · Cited by 7 · see citing works
Se, S. (1972) · PubMed · Cited by 5 · see citing works
Vulnerability to fluoxetine-induced indifference syndrome among opiate addicts: A case report
Bertschy, G., & Baumann, P. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00219-7 · Cited by 4 · see citing works
Changes in methadone pharmacokinetics during pregnancy
Pond, S. M., Kreek, M. J., Tong, T. G., & Benowitz, N. L. (1982) · Clinical research · Cited by 4 · see citing works
Fornataro, K. (1999) · PubMed · Cited by 3 · see citing works
Buprenorphine Therapy of Opiate Addiction
(President), P. K., & Pharmacology), P. M. (. O. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-282-1 · Cited by 2 · see citing works
Flagged first, then by citations
5 of the 137 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Center for Substance Abuse Treatment. State Methadone Treatment Guidelines. (Treatment Improvement Protocol Series 1) Rockville, MD: US Department of Health and Human Services; 1993. [Google Scholar]
- Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. (Treatment Improvement Protocol Series 40) Rockville, MD: US Department of Health and Human Services; 2004. [PubMed] [Google Scholar]
- Center for Substance Abuse Treatment. Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs. (Treatment Improvement Protocol Series 43) Rockville, MD: US Department of Health and Human Services; 2005. [PubMed] [Google Scholar]
- Cowan A. Update of the general pharmacology of buprenorphine. In: Lewis J, Cowan A, editors. Buprenorphine: combating drug abuse with a unique opioid. New York: Wiley; 1995. pp. 31–47. [Google Scholar]
- Dunlop A, Panjari M, O’Sullivan H, et al. Clinical Guidelines for the Use of Buprenorphine during Pregnancy. Fitzroy: Turning Point Alcohol and Drug Centre; 2003. [Google Scholar]
- Gazaway PM, Bigelow GE, Brooner RK. The influence of pregnancy upon trough plasma levels of methadone and its' opioid effects. NIDA Research Monograph. 1993;132:112. [Google Scholar]
- Meyer M, Paranya G, Kristensen E, Plante D. Buprenorphine impairs intrapartum patient controlled epidural analgesia (PCEA) efficacy. Poster presentation presented at the annual meeting of the Society of Obstetric Anesthesia and Perinatology; Alberta, Canada. 2007b. [Google Scholar]
Cited by
Sorted by citations
Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure
Jones, H. E., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Arria, A. M., O'Grady, K. E., Selby, P., Martin, P. R., & Fischer, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005359 · Cited by 986 · see citing works
Self-citationCommittee Opinion No. 711: Opioid Use and Opioid Use Disorder in Pregnancy
(2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002235 · Cited by 674 · see citing works
The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics
Sachs, H. C., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Johnson, T., Neville, K. A., Paul, I. M., & van den Anker, J. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1985 · Cited by 553 · see citing works
Management of opioid use disorders: a national clinical practice guideline
Bruneau, J., Ahamad, K., Goyer, M.-È., Poulin, G., Selby, P. L., Fischer, B., Wild, T. C., & Wood, E. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.170958 · Cited by 412 · see citing works
Self-citationKraus, M. L., Alford, D. P., Kotz, M. M., Levounis, P., Mandell, T. W., Meyer, M. C., Salsitz, E. A., Wetterau, N., & Wyatt, S. A. (2011) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e3182312983 · Cited by 265 · see citing works
Unintended pregnancy in opioid-abusing women
Heil, S. H., Jones, H. E., Arria, A. M., Kaltenbach, K. A., Coyle, M. G., Fischer, G., Stine, S. M., Selby, P. L., & Martin, P. (2010) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2010.08.011 · Cited by 264 · see citing works
Self-citationThe United States opioid epidemic
Lyden, J. R., & Binswanger, I. A. (2019) · Seminars in Perinatology · doi:10.1053/j.semperi.2019.01.001 · Cited by 249 · see citing works
Maintenance agonist treatments for opiate dependent pregnant women
Minozzi, S., Amato, L., Vecchi, S., & Davoli, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006318.pub2 · Cited by 225 · see citing works
Grella, C. E. (2008) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2008.10400661 · Cited by 209 · see citing works
Buprenorphine treatment of opioid‐dependent pregnant women: a comprehensive review
Jones, H. E., Heil, S. H., Baewert, A., Arria, A. M., Kaltenbach, K. A., Martin, P., Coyle, M. G., Selby, P. L., Stine, S. M., & Fischer, G. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.04035.x · Cited by 176 · see citing works
Self-citationWinklbaur, B., Kopf, N., Ebner, N., Jung, E., Thau, K., & Fischer, G. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02283.x · Cited by 169 · see citing works
Self-citationBuprenorphine versus Methadone for Opioid Use Disorder in Pregnancy
Suarez, E. A., Huybrechts, K. F., Straub, L., Hernández–Dı́az, S., Jones, H. E., Connery, H. S., Davis, J. M., Gray, K. J., Lester, B. M., Terplan, M., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2203318 · Cited by 169 · see citing works
Self-citationPrenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications.
Minnes, S., Lang, A., & Singer, L. T. (2011) · Europe PMC (PubMed Central) · Cited by 160 · see citing works
Management of psychotropic drugs during pregnancy
Chisolm, M. S., & Payne, J. L. (2016) · BMJ · doi:10.1136/bmj.h5918 · Cited by 135 · see citing works
Increasing pregnancy-related use of prescribed opioid analgesics
EPSTEIN, R. A., Bobo, W. V., Martin, P., Morrow, J. A., Wang, W., Chandrasekhar, R., & Cooper, W. O. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.05.017 · Cited by 127 · see citing works
Self-citationWelle-Strand, G. K., Skurtveit, S. O., Jones, H. E., Waal, H., Bakstad, B., Bjarkø, L., & Ravndal, E. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.07.001 · Cited by 123 · see citing works
Self-citationClinical care for opioid-using pregnant and postpartum women: the role of obstetric providers
Jones, H. E., Deppen, K., Hudak, M. L., Leffert, L. R., McClelland, C., Şahin, L., Starer, J., Terplan, M., Thorp, J. M., Walsh, J., et al. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.10.010 · Cited by 117 · see citing works
Self-citationMaintenance agonist treatments for opiate-dependent pregnant women
Minozzi, S., Amato, L., Bellisario, C., Ferri, M., & Davoli, M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006318.pub3 · Cited by 114 · see citing works
Management of injecting drug users admitted to hospital
Haber, P., Demirkol, A., Lange, K. J., & Murnion, B. P. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61036-9 · Cited by 114 · see citing works
Soyka, M., Kranzler, H. R., van den Brink, W., Krystal, J. H., Möller, H., Kasper, S. F., & The WFSBP Task Force on Treatment, G. F. S. U. D. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.561872 · Cited by 112 · see citing works
Unplanned pregnancy and contraceptive use in women attending drug treatment services
Black, K. I., Stephens, C., Haber, P., & Lintzeris, N. (2012) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2012.01413.x · Cited by 105 · see citing works
Buprenorphine and Naloxone Compared With Methadone Treatment in Pregnancy
Wiegand, S. L., Stringer, E. M., Stuebe, A. M., Jones, H. E., Seashore, C. J., & Thorp, J. M. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000000640 · Cited by 102 · see citing works
Self-citationBenningfield, M. M., Arria, A. M., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Fischer, G., Jones, H. E., & Martin, P. R. (2010) · The American Journal on Addictions · doi:10.1111/j.1521-0391.2010.00064.x · Cited by 96 · see citing works
Self-citationBrown, J. D., Goodin, A. J., & Talbert, J. (2017) · The Journal of Rural Health · doi:10.1111/jrh.12251 · Cited by 95 · see citing works
Neonatal neurobehavior effects following buprenorphine versus methadone exposure
Coyle, M. G., Salisbury, A. L., Lester, B. M., Jones, H. E., Lin, H., Graf‐Rohrmeister, K., & Fischer, G. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.04040.x · Cited by 92 · see citing works
Self-citationPolysubstance Use Among US Women of Reproductive Age Who Use Opioids for Nonmedical Reasons
Jarlenski, M., Barry, C. L., Gollust, S. E., Graves, A. J., Kennedy‐Hendricks, A., & Kozhimannil, K. B. (2017) · American Journal of Public Health · doi:10.2105/ajph.2017.303825 · Cited by 82 · see citing works
Prenatal and Postpartum Care of Women with Substance Use Disorders
Gopman, S. (2014) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2014.02.004 · Cited by 88 · see citing works
Gender Issues in the Pharmacotherapy of Opioid-Addicted Women: Buprenorphine
Unger, A., Jung, E., Winklbaur, B., & Fischer, G. (2010) · Journal of Addictive Diseases · doi:10.1080/10550881003684814 · Cited by 77 · see citing works
Self-citationMethadone and Buprenorphine Toxicity in Children
Boyer, E. W., McCance‐Katz, E. F., & Marcus, S. M. (2009) · American Journal on Addictions · doi:10.1111/j.1521-0391.2009.00002.x · Cited by 69 · see citing works
Fetal neurobehavioral effects of exposure to methadone or buprenorphine
Jansson, L. M., DiPietro, J. A., Vélez, M. L., Elko, A., Williams, E., Milio, L. A., O’Grady, K. E., & Jones, H. E. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.09.003 · Cited by 68 · see citing works
Self-citationGoodman, D. (2015) · Journal of Midwifery & Women's Health · doi:10.1111/jmwh.12340 · Cited by 65 · see citing works
Bisaga, A. M., Mannelli, P., Sullivan, M. A., Vosburg, S. K., Compton, P. A., WOODY, G. E., & Kosten, T. R. (2018) · American Journal on Addictions · doi:10.1111/ajad.12711 · Cited by 62 · see citing works
Bailey, B. A., McCook, J. G., Hodge, A., & McGrady, L. (2011) · Maternal and Child Health Journal · doi:10.1007/s10995-011-0776-y · Cited by 61 · see citing works
Benningfield, M. M., Dietrich, M. S., Jones, H. E., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Arria, A. M., O'Grady, K. E., Fischer, G., et al. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.04041.x · Cited by 60 · see citing works
Self-citationPsychopharmacologic Management of Opioid‐Dependent Women during Pregnancy
Martin, P., Arria, A. M., Fischer, G., Kaltenbach, K. A., Heil, S. H., Stine, S. M., Coyle, M. G., Selby, P. L., & Jones, H. E. (2009) · American Journal on Addictions · doi:10.1080/10550490902772975 · Cited by 59 · see citing works
Self-citationConcheiro, M., Jones, H. E., Johnson, R. E., Choo, R. E., Shakleya, D. M., & Huestis, M. A. (2010) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e3181d0bd68 · Cited by 59 · see citing works
Self-citationJones, H. E., Heil, S. H., O’Grady, K. E., Martin, P. R., Kaltenbach, K. A., Coyle, M., Stine, S. M., Selby, P. L., Arria, A. M., & Fischer, G. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990903125235 · Cited by 56 · see citing works
Self-citationConcheiro, M., Jones, H. E., Johnson, R. E., Choo, R. E., & Huestis, M. A. (2011) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e318228bb2a · Cited by 53 · see citing works
Self-citationMeinhofer, A., Hinde, J. M., & Ali, M. M. (2019) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2019.12.005 · Cited by 54 · see citing works
Maintenance agonist treatments for opiate-dependent pregnant women
Minozzi, S., Amato, L., Jahanfar, S., Bellisario, C., Ferri, M., & Davoli, M. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006318.pub4 · Cited by 53 · see citing works
Drug use and pregnancy – challenges for public health
Gyarmathy, V. A., Giraudon, I., Hedrich, D., Montanari, L., Guarita, B., & Wiessing, L. G. (2009) · Eurosurveillance · doi:10.2807/ese.14.09.19142-en · Cited by 52 · see citing works
Impact of treatment approach on maternal and neonatal outcome in pregnant opioid‐maintained women
Metz, V. E., Jagsch, R., Ebner, N., Würzl, J., Pribasnig, A., Aschauer, C., & Fischer, G. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1224 · Cited by 52 · see citing works
Self-citationNeonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid CrisisPreprint
Weller, A. E., Crist, R. C., Reiner, B. C., Doyle, G. A. R., & Berrettini, W. H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039669 · Cited by 52 · see citing works
Developmental Consequences of Prenatal Substance Use in Children and Adolescents
Guille, C., & Aujla, R. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0177 · Cited by 49 · see citing works
Jumah, N. A., Edwards, C., Balfour-Boehm, J., Loewen, K., Dooley, J., Gerber-Finn, L., & Kelly, L. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011774 · Cited by 45 · see citing works
The treatment of alcohol and opioid dependence in pregnant women
Heberlein, A., Leggio, L., Stichtenoth, D. O., & Hillemacher, T. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328358ad36 · Cited by 43 · see citing works
Davie‐Gray, A., Moor, S., Spencer, C., & Woodward, L. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.04.006 · Cited by 42 · see citing works
Concheiro, M., Jones, H. E., Johnson, R. E., Choo, R. E., Shakleya, D. M., & Huestis, M. A. (2010) · Journal of Analytical Toxicology · doi:10.1093/jat/34.8.498 · Cited by 38 · see citing works
Self-citationPrenatal opioid exposure and vulnerability to future substance use disorders in offspring
Abu, Y. F., & Roy, S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113621 · Cited by 38 · see citing works
Effects of opioids on the parental brain in health and disease
Swain, J. E., Ho, S.-H. S., Fox, H. C., Garry, D. J., & Brummelte, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100766 · Cited by 37 · see citing works
Treatment of Opioid Dependence in the Setting of Pregnancy
Young, J. L., & Martin, P. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.008 · Cited by 35 · see citing works
Self-citationO’Connor, A. B., Alto, W. A., Musgrave, K., Gibbons, D. C., Llanto, L., Holden, S., & Karnes, J. (2011) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2011.02.100155 · Cited by 35 · see citing works
Are Male Neonates More Vulnerable to Neonatal Abstinence Syndrome Than Female Neonates?
Unger, A., Jagsch, R., Bäwert, A., Winklbaur, B., Rohrmeister, K., Martin, P., Coyle, M. G., & Fischer, G. (2011) · Gender Medicine · doi:10.1016/j.genm.2011.10.001 · Cited by 34 · see citing works
Self-citationChanges in methadone maintenance therapy during and after pregnancy
Albright, B. B., de la Torre, L., SKIPPER, B. J., Price, S., Abbott, P., & Rayburn, W. F. (2011) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.05.002 · Cited by 33 · see citing works
Heller, N. A., Logan, B. A., Morrison, D. G., Paul, J. A., Brown, M. S., & Hayes, M. J. (2017) · Developmental Psychobiology · doi:10.1002/dev.21532 · Cited by 33 · see citing works
Pharmacological treatment of opioid use disorder in pregnancy
Rodriguez, C. E., & Klie, K. A. (2019) · Seminars in Perinatology · doi:10.1053/j.semperi.2019.01.003 · Cited by 32 · see citing works
Tsuda‐McCaie, F., & Kotera, Y. (2022) · Drug and Alcohol Review · doi:10.1111/dar.13421 · Cited by 34 · see citing works
Unger, A., Jagsch, R., Jones, H. E., Arria, A. M., Leitich, H., Rohrmeister, K., Aschauer, C., Winklbaur, B., Bäwert, A., & Fischer, G. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03440.x · Cited by 32 · see citing works
Self-citationManagement of women treated with buprenorphine during pregnancy
Alto, W. A., & O’Connor, A. B. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.04.001 · Cited by 31 · see citing works
Bachhuber, M. A., Mehta, P., Faherty, L. J., & Saloner, B. K. (2017) · Medical Care · doi:10.1097/mlr.0000000000000803 · Cited by 31 · see citing works
Pharmacological Management of Opioid Use Disorder in Pregnant Women
Wilder, C. M., & Winhusen, T. M. (2015) · CNS Drugs · doi:10.1007/s40263-015-0273-8 · Cited by 30 · see citing works
Schlagal, C. R., Dunn, T. J., Xu, P., Felsing, D. E., Merritt, C. R., Manja, S., Fox, R. G., Buffington, S. A., Saade, G. R., Dineley, K. T., et al. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.03.014 · Cited by 29 · see citing works
Meyer, M. C., Benvenuto, A., Howard, D. B., Johnston, A., Plante, D., Metayer, J., & Mandell, T. W. (2012) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e3182541933 · Cited by 29 · see citing works
Sutter, M. B., Watson, H., Bauers, A., JOHNSON, K., Hatley, M., Yonke, N., & Leeman, L. M. (2019) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.12960 · Cited by 28 · see citing works
Safe Management of Chronic Pain in Pregnancy in an Era of Opioid Misuse and Abuse
Pritham, U. A., & McKay, L. (2014) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/1552-6909.12487 · Cited by 28 · see citing works
First Trimester Use of Buprenorphine or Methadone and the Risk of Congenital Malformations
Suarez, E. A., Bateman, B. T., Straub, L., Hernández–Dı́az, S., Jones, H. E., Gray, K. J., Connery, H. S., Davis, J. M., Lester, B. M., Terplan, M., et al. (2024) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.6986 · Cited by 28 · see citing works
Self-citationKo, J. Y., Tong, V. T., Haight, S., Terplan, M., Snead, C. M., & Schulkin, J. (2019) · Journal of Perinatology · doi:10.1038/s41372-019-0535-2 · Cited by 23 · see citing works
Advances in animal models of prenatal opioid exposure
Ferrante, J. R., & Blendy, J. A. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.03.005 · Cited by 26 · see citing works
Concheiro, M., Jones, H. E., Johnson, R. E., Shakleya, D. M., & Huestis, M. A. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.11.005 · Cited by 26 · see citing works
Self-citationIllicit drug use in pregnancy: effects and management
MADGULA, R., Groshkova, T., & Mayet, S. (2011) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.10.54 · Cited by 25 · see citing works
Apsley, H. B., Brant, K., Brothers, S., Harrison, E., Skogseth, E. M., Schwartz, R. P., & Jones, A. A. (2024) · Women s Health · doi:10.1177/17455057231224181 · Cited by 23 · see citing works
“Subutex is safe”: Perceptions of risk in using illicit drugs during pregnancy
Leppo, A. (2012) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2012.01.004 · Cited by 24 · see citing works
Janssen, P. A., Demorest, L. C., Kelly, A. M., Thiessen, P. N., & Abrahams, R. (2012) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/1747-597x-7-48 · Cited by 24 · see citing works
Initiation and Engagement with Methadone Treatment among Pregnant and Postpartum Women
Mattocks, K. M., Clark, R. E., & Weinreb, L. (2017) · Women s Health Issues · doi:10.1016/j.whi.2017.05.002 · Cited by 24 · see citing works
Pharmacotherapies for the Treatment of Alcohol Use Disorders During Pregnancy: Time to Reconsider?
Kelty, E. A., Terplan, M., Greenland, M., & Preen, D. B. (2021) · Drugs · doi:10.1007/s40265-021-01509-x · Cited by 25 · see citing works
Postpartum changes in methadone maintenance dose
Pace, C. A., Kaminetzky, L. B., Winter, M. R., Cheng, D. M., Saia, K., Samet, J. H., & Walley, A. Y. (2014) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2014.04.004 · Cited by 21 · see citing works
Opioid use disorder in pregnancy
Harter, K. (2019) · Mental Health Clinician · doi:10.9740/mhc.2019.11.359 · Cited by 21 · see citing works
Unger, A., Martin, P., Kaltenbach, K. A., Stine, S. M., Heil, S. H., Jones, H. E., Arria, A. M., Coyle, M. G., Selby, P. L., & Fischer, G. (2010) · European Addiction Research · doi:10.1159/000284683 · Cited by 21 · see citing works
Self-citationStine, S. M., Heil, S. H., Kaltenbach, K. A., Martin, P., Coyle, M. G., Fischer, G., Arria, A. M., Selby, P. L., & Jones, H. E. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990903374080 · Cited by 20 · see citing works
Self-citationOpioid misuse as a coping behavior for unmet mental health needs among U.S. adults
Cruden, G., & Karmali, R. N. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108805 · Cited by 20 · see citing works
Welle-Strand, G. K., Skurtveit, S. O., Tanum, L., Waal, H., Bakstad, B., Bjarkø, L., & Ravndal, E. (2015) · European Addiction Research · doi:10.1159/000381670 · Cited by 20 · see citing works
Neonatal outcomes following in utero exposure to buprenorphine/naloxone or methadone
Gawronski, K. M., Prasad, M. R., Backes, C. R., Lehman, K. J., Gardner, D. K., & Cordero, L. (2014) · SAGE Open Medicine · doi:10.1177/2050312114530282 · Cited by 20 · see citing works
Lim, G., Soens, M., Wanaselja, A., Chyan, A., Carvalho, B., Landau, R., George, R. B., Klem, M. L., Osmundson, S. S., Krans, E. E., et al. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006167 · Cited by 19 · see citing works
Evaluation and Management of Opioid Dependence in Pregnancy
Park, E. M., Meltzer-Brody, S. E., & Suzuki, J. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.04.003 · Cited by 19 · see citing works
Miller, C. D., Grynspan, D., Gaudet, L., Ferretti, E., Lawrence, S. L., Moretti, F., Lafreniere, A. J., McGee, A., Lattuca, S., & Black, A. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000478 · Cited by 19 · see citing works
Buprenorphine Use in Pregnant Opioid Users: A Critical Review
Soyka, M. (2013) · CNS Drugs · doi:10.1007/s40263-013-0072-z · Cited by 19 · see citing works
Goldfarb, S. S., Stanwood, G. D., Flynn, H. A., & Graham, D. L. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219883601 · Cited by 18 · see citing works
Lessons learned from a comparison of evidence‐based research in pregnant opioid‐dependent women
Winklbaur, B., Jagsch, R., Graf‐Rohrmeister, K., Unger, A., Baewert, A., Langer, M., Thau, K., & Fischer, G. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2275 · Cited by 17 · see citing works
Self-citationInitial Feasibility of a Woman-Focused Intervention for Pregnant African-American Women
Jones, H. E., Berkman, N. D., Kline, T., Ellerson, R. M., Browne, F. A., Poulton, W., & Wechsberg, W. M. (2011) · International Journal of Pediatrics · doi:10.1155/2011/389285 · Cited by 17 · see citing works
Self-citationMedications for opioid use disorder in pregnancy in a state women’s prison facility
Knittel, A. K., Zarnick, S., Thorp, J. M., Amos, E., & Jones, H. E. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108159 · Cited by 17 · see citing works
Self-citationBaewert, A., Jagsch, R., Winklbaur, B., Kaiser, G., Thau, K., Unger, A., Aschauer, C., Weninger, M., & Metz, V. E. (2012) · European Addiction Research · doi:10.1159/000335082 · Cited by 16 · see citing works
The management of opioid dependence during pregnancy in rural and remote settings
Jumah, N. A., Graves, L. E., & Kahan, M. (2014) · Canadian Medical Association Journal · doi:10.1503/cmaj.131723 · Cited by 16 · see citing works
Investigating Mechanisms of Stillbirth in the Setting of Prenatal Substance Use
Miller, C. B., & Wright, T. E. (2018) · Academic Forensic Pathology · doi:10.1177/1925362118821471 · Cited by 15 · see citing works
Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study
Badhan, R. K. S., & Gittins, R. (2021) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2021.108521 · Cited by 15 · see citing works
Trends in Injection Drug Use Among Pregnant Women Admitted into Drug Treatment: 1994–2006
Terplan, M., Smith, E. J., & Glavin, S. H. (2010) · Journal of Women s Health · doi:10.1089/jwh.2009.1562 · Cited by 15 · see citing works
Leeman, L. M., Brown, S. A., Albright, B. B., SKIPPER, B. J., Hsi, A., & Rayburn, W. F. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2010.536863 · Cited by 15 · see citing works
Knittel, A. K., Swartzwelder, R. A., Zarnick, S., Tsujimoto, T. H. M., Horne, T., Lin, F., Edwards, J., Amos, E., Alexander, J. M., Thorp, J. M., et al. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109308 · Cited by 14 · see citing works
Self-citationPadwa, H., Mark, T. L., & Wondimu, B. B. (2020) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000804 · Cited by 14 · see citing works
Mahoney, K., Reich, W., & Urbanek, S. (2019) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/nmc.0000000000000551 · Cited by 14 · see citing works
BODEN, S. L., Jones, C., & Cabacungan, E. (2021) · Maternal and Child Health Journal · doi:10.1007/s10995-021-03127-1 · Cited by 13 · see citing works
- Authors
- Jones, H. E., Martin, P. R., Heil, S. H., Kaltenbach, K., Selby, P., Coyle, M. G., Stine, S. M., O'Grady, K. E., Arria, A. M., & Fischer, G.
- Affiliations
- Vanderbilt University (US)
- University of Vermont (US)
- Thomas Jefferson University (US)
- University of Toronto (CA)
- Brown University (US)
- Wayne State University (US)
- University of Maryland, College Park (US)
- Medical University of Vienna (AT)
- ORCID
- Venue
- Journal of Substance Abuse Treatment
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 35
- Issue
- 3
- Pages
- 245-259
- ISSN
- 0740-5472 (ISSN-L)
- PMC
- PMC2633026
- OpenAlex
- W2094830932
- Cited by
- 191
- References
- 137
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 16
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Substance Abuse Treatment (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Rice University
- University of Vermont
- Universität Wien
- National Institute on Drug Abuse (R01 DA15832, R01DA015778, R01DA015764, R01DA 0184103, R01DA015713, R01DA 0175138, R01DA015832, R01DA015741, R01DA015738, R01DA018410, R01DA018417)
- National Center for Research Resources (M01RR000095, M01RR000109, M01-RR-00095)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- opioid use disorder, pregnancy, maternal opioid treatment, methadone, buprenorphine, neonatal outcomes, induction, stabilization, pain management, breastfeeding, follow-up care, psychiatric comorbidity, drug interactions, clinical decision-making
- MeSH terms
- Analgesics, Opioid, Buprenorphine, Clinical Trials as Topic, Decision Making, Female, Humans, Infant, Newborn, Methadone, Opioid-Related Disorders, Pain, Pregnancy, Pregnancy Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
