The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene
Abstract
BTG2/TIS21/PC3 protein is involved in the regulation of G1/S transition of the cell cycle by inhibiting pRb function, suggesting that BTG2/TIS21/PC3 regulation is critical for normal cell growth and proliferation. To understand the regulatory mechanisms for the expression of BTG2/TIS21/PC3 we cloned the human gene. Potential binding sites for several transcription factors were identified in the 5'-flanking region of the gene. Transient expression assays with BTG2/TIS21/PC3 promoter deletions and electrophoretic mobility shift analysis identified a major wild-type p53 response element located -74 to -122 relative to the start codon. This genomic fragment was sufficient to constitute a promoter element in the presence of p53. The BTG2/TIS21/PC3 gene is an antiproliferative gene which maps within a chromosomal segment (1q32) frequently altered in breast adenocarcinomas. However, no mutations of BTG2/TIS21/PC3 were detected in breast cancer cells, suggesting that the inactivation of this gene is not a frequent genetic event during breast carcinogenesis.
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BTG2 can induce G1/S cell cycle arrest.
“The p53 target genes BTG236, 154, 155 and GADD45A13, 156 can also induce G1/S and G2/M cell cycle arrest, respectively.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [36]
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- Authors
- Duriez, C., Falette, N., Audoynaud, C., Moyret-Lalle, C., Bensaad, K., Courtois, S., Wang, Q., Soussi, T., & Puisieux, A.
- Affiliations
- Inserm (FR)
- Institut Curie (FR)
- Corresponding author
- Puisieux, Alain
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 282
- Issue
- 1-2
- Pages
- 207-214
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W1991407069
- Cited by
- 73
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- tumor suppressor, gene cloning, transcriptional regulation, p53 response elements, 5'-flanking region, promoter, retinoblastoma protein, G1/S cell cycle arrest, breast adenocarcinoma, chromosome 1q32, mammary carcinogenesis
- MeSH terms
- Base Sequence, Gene Expression Regulation, Genes, Genetic Vectors, Genotype, Humans, Luciferases, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Recombinant Fusion Proteins, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Immediate-Early Proteins, Tumor Suppressor Proteins
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