Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.
Open accessAbstract
The involvement of Sp1 in regulating cell proliferation in myeloid leukemia cells was determined by measuring the levels and DNA binding activity of Sp1 in TF-1 cells, a human erythroleukemia cell line dependent on granulocyte/macrophage colony-stimulating factor (GM-CSF) for viability and cell growth. DNA binding of Sp1 to a specific double-stranded oligodeoxynucleotide was increased markedly in a dose-dependent manner in proliferating cells in response to GM-CSF compared with growth-arrested or apoptotic cells. Competition experiments and mobility shift interference assays with antibodies against Sp1 as well as wild-type or mutant p53 indicated that GM-CSF-inducible DNA-binding complexes contained both Sp1 and p53 and that these heterocomplexes bound to both p53- and Sp1-binding sequences with high affinity. Immunoprecipitation of nuclear extracts with a p53 antibody indicated that Sp1 was associated as a heterocomplex with p53. Formation of this complex was dependent on the level of p53 since p53 was more abundant in proliferating cells and decreased upon induction of growth arrest and apoptosis by withdrawal of GM-CSF while Sp1 levels remained unchanged. These results suggest that the association of Sp1 with p53 may represent a novel mechanism of growth regulation in cytokine-dependent leukemia cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
p53 was first reported to bind to coactivators including TATA-box binding protein, NF-Y, and Sp1, and to interfere with their transactivator function.
“In 1993, p53 was first reported to bind to coactivators, including the TATA-box binding protein,73, 74 the CCAAT-box binding factor (NF-Y)75 and specificity protein 1 (Sp1) that binds to GC-boxes,76 and to interfere with their transactivator function.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [76]
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
Wyllie, A. H. (1980) · Nature · doi:10.1038/284555a0 · Cited by 4,549 · see citing works
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785 · see citing works
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046 · see citing works
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,443 · see citing works
Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337 · see citing works
Fos and jun: The AP-1 connection
Curran, T., & Franza, B. R. (1988) · Cell · doi:10.1016/0092-8674(88)90024-4 · Cited by 1,595 · see citing works
Regulation of Inducible and Tissue-Specific Gene Expression
Maniatis, T., Goodbourn, S., & Fischer, J. A. (1987) · Science · doi:10.1126/science.3296191 · Cited by 1,553 · see citing works
Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445 · see citing works
Imagawa, M. (1987) · Cell · doi:10.1016/0092-8674(87)90152-8 · Cited by 1,384 · see citing works
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins
Dynan, W. S., & Tjian, R. (1985) · Nature · doi:10.1038/316774a0 · Cited by 1,251 · see citing works
Apoptosis And Programmed Cell Death In Immunity
Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112 · see citing works
Identification of p53 as a Sequence-Specific DNA-Binding Protein
Kern, S. E., Kinzler, K. W., Bruskin, A. M., Jarosz, D., Friedman, P. N., Prives, C. L., & Vogelstein, B. (1991) · Science · doi:10.1126/science.2047879 · Cited by 1,085 · see citing works
Gannon, J., Greaves, R. F., Iggo, R. D., & Lane, D. P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08279.x · Cited by 970 · see citing works
Mitchell, P. J., Wang, C. I., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90512-5 · Cited by 904 · see citing works
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
Williams, G. T., Smith, C. A., Spooncer, E., Dexter, T. M., & Taylor, D. R. (1990) · Nature · doi:10.1038/343076a0 · Cited by 887 · see citing works
Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells
Koury, M. J., & Bondurant, M. C. (1990) · Science · doi:10.1126/science.2326648 · Cited by 841 · see citing works
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro
Jones, K. A., Yamamoto, K. R., & Tjian, R. (1985) · Cell · doi:10.1016/0092-8674(85)90113-8 · Cited by 806 · see citing works
Kitamura, T., Tange, T., Terasawa, T., Chiba, S., Kuwaki, T., Miyagawa, K., Piao, Y., Miyazono, K., Urabe, A., & Takaku, F. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041400219 · Cited by 784 · see citing works
Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1
Jones, K. A., Kadonaga, J. T., Luciw, P. A., & Tjian, R. (1986) · Science · doi:10.1126/science.3008338 · Cited by 702 · see citing works
Santoro, C., Mermod, N., Andrews, P., & Tjian, R. (1988) · Nature · doi:10.1038/334218a0 · Cited by 696 · see citing works
Activation of HIV gene expression during monocyte differentiation by induction of NF-kB
Griffin, G. E., Leung, K., Folks, T. M., Kunkel, S. L., & Nabel, G. J. (1989) · Nature · doi:10.1038/339070a0 · Cited by 583 · see citing works
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
Courey, A. J., Holtzman, D. A., Jackson, S. P., & Tjian, R. (1989) · Cell · doi:10.1016/0092-8674(89)90606-5 · Cited by 524 · see citing works
Growth regulation of a cellular tumour antigen, p53, in nontransformed cells
Reich, N. C., & Levine, A. J. (1984) · Nature · doi:10.1038/308199a0 · Cited by 517 · see citing works
Banks, L., Matlashewski, G., & Crawford, L. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09919.x · Cited by 505 · see citing works
Pascal, E., & Tjian, R. (1991) · Genes & Development · doi:10.1101/gad.5.9.1646 · Cited by 441 · see citing works
Bargonetti, J., Friedman, P. N., Kern, S. E., Vogelstein, B., & Prives, C. L. (1991) · Cell · doi:10.1016/0092-8674(91)90560-l · Cited by 367 · see citing works
Li, R., Knight, J. D., Jackson, S. P., Tjian, R., & Botchan, M. R. (1991) · Cell · doi:10.1016/0092-8674(91)90467-d · Cited by 303 · see citing works
Ueda, K., Pastan, I. H., & Gottesman, M. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45397-5 · Cited by 290 · see citing works
Mercer, W. E., Nelson, D., DeLeo, A. B., Old, L. J., & Baserga, R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.20.6309 · Cited by 255 · see citing works
The Retinoblastoma Gene Product Regulates Sp1-Mediated Transcription
Kim, S. J., Onwuta, U. S., Lee, Y. I., Li, R., Botchan, M. R., & Robbins, P. D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2455 · Cited by 246 · see citing works
Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.
Mercer, W. E., Avignolo, C., & Baserga, R. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.2.276 · Cited by 216 · see citing works
Frequent mutations in the p53 gene in human myeloid leukemia cell lines
Sugimoto, K., Toyoshima, H., Sakai, R., Miyagawa, K., Hagiwara, K., Ishikawa, F., Takaku, F., Yazaki, Y., & Hirai, H. (1992) · Blood · doi:10.1182/blood.v79.9.2378.2378 · Cited by 213 · see citing works
The p53 tumor suppressor protein, a modulator of cell proliferation.
Ullrich, S. J., Anderson, C. W., Mercer, W. E., & Appella, E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49524-0 · Cited by 168 · see citing works
Sherman, M. L., Stone, R. M., Datta, R., Bernstein, S. H., & Kufe, D. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39769-8 · Cited by 166 · see citing works
Rajotte, D., Haddad, P. S., Haman, A., Cragoe, E. J., & Hoang, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50188-0 · Cited by 152 · see citing works
Programmed cell death (apoptosis) in hematopoiesis.
Mj, K. (1992) · PubMed · Cited by 149 · see citing works
Oligomerization of oncoprotein p53
Kraiss, S., Quaiser, A., Oren, M., & Montenarh, M. (1988) · Journal of Virology · doi:10.1128/jvi.62.12.4737-4744.1988 · Cited by 147 · see citing works
Cooperative interactions between transcription factors Sp1 and OTF-1.
Janson, L., & Pettersson, U. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4732 · Cited by 115 · see citing works
A DNA binding domain is contained in the C-terminus ofwild typep53 protein
Foord, O., Bhattacharya, P., Reich, Z., & Rotter, V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.19.5191 · Cited by 111 · see citing works
Yu, G., Smithgall, T. E., & Glazer, R. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81796-3 · Cited by 100 · see citing works
Self-citationAdunyah, S. E., Unlap, T., Wagner, F., & Kraft, A. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67647-7 · Cited by 66 · see citing works
Stein, G., Lian, J. B., Stein, J. L., Briggs, R. C., Shalhoub, V., Wright, K., Pauli, U., & van Wijnen, A. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.6.1865 · Cited by 57 · see citing works
Borellini, F., Aquino, A., Josephs, S. F., & Glazer, R. I. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5541 · Cited by 44 · see citing works
Self-citationBorellini, F., He, Y., Aquino, A., Yu, G., Josephs, S. F., & Glazer, R. I. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98486-3 · Cited by 38 · see citing works
Self-citationNakamura, T., Datta, R., Kharbanda, S. M., & Kufe, D. W. (1991) · PubMed · Cited by 35 · see citing works
Shabo, Y., Lotem, J., & Sachs, L. (1990) · PubMed · Cited by 21 · see citing works
Kraiss, S., Lorenz, A., & Montenarh, M. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90227-5 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works
Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2641 · Cited by 1,647 · see citing works
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
Black, A. R., Black, J. D., & Azizkhan‐Clifford, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1111 · Cited by 1,049 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression
Owen‐Schaub, L. B., Zhang, W. K., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A., Zhang, W., Kruzel, E., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3032 · Cited by 731 · see citing works
Mirza, A., McGuirk, M., Hockenberry, T., Wu, Q. J., Ashar, H. R., Black, S., Wen, S. F., Wang, L., Kirschmeier, P. T., Bishop, W. R., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205353 · Cited by 530 · see citing works
p53 in growth control and neoplasia
Gottlieb, T. M., & Oren, M. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(95)00019-c · Cited by 481 · see citing works
Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions
Safe, S. H. (2001) · Vitamins and hormones · doi:10.1016/s0083-6729(01)62006-5 · Cited by 418 · see citing works
Mukhopadhyay, D., Knebelmann, B., Cohen, H. T., Karumanchi, S. A., & Sukhatme, V. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5629 · Cited by 337 · see citing works
Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer.
Wang, L., Wei, D., Huang, S., Peng, Z., Le, X., Wu, T. T., Yao, J. C., Ajani, J. A., & Xie, K. (2003) · PubMed · Cited by 334 · see citing works
Harris, C. C. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1187 · Cited by 284 · see citing works
Xu, D., Wang, Q., Gruber, A., Björkholm, M., Chen, Z., Zaid, A., Selivanova, G., Peterson, C., Wiman, K. G., & Pisa, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203890 · Cited by 257 · see citing works
Zhang, Q., Gutsch, D. E., & Kenney, S. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1929 · Cited by 237 · see citing works
Zhang, L., Yu, D., Hu, M., Xiong, S., Lang, A., Ellis, L. M., & Pollock, R. E. (2000) · PubMed · Cited by 230 · see citing works
Egger, G., Doetzlhofer, A., Schuettengruber, B., Haidweger, E., Simboeck, E., Tischler, J., Chiocca, S., Suske, G., Rotheneder, H., Wintersberger, E., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2669-2679.2003 · Cited by 214 · see citing works
Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase
Rohlff, C., Ahmad, S., Borellini, F., Lei, J., & Glazer, R. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21137 · Cited by 206 · see citing works
Self-citationYao, J. C., Wang, L., Wei, D., Gong, W., Hassan, M. M., Wu, T., Mansfield, P. F., Ajani, J. A., & Xie, K. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0628 · Cited by 199 · see citing works
Activation of the cryptic DNA binding function of mutant forms of p53
Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3167 · Cited by 189 · see citing works
Mirza, A., Wu, Q. J., Wang, L., McClanahan, T., Bishop, W. R., Gheyas, F., Ding, W., Hutchins, B., Hockenberry, T., Kirschmeier, P. T., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206477 · Cited by 183 · see citing works
Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53
Ludes-Meyers, J. H., Subler, M. A., Shivakumar, C. V., Muñoz, R. M., Jiang, P., Bigger, J. E., Brown, D. R., Deb, S. P., & Deb, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6009 · Cited by 181 · see citing works
Thottassery, J. V., Zambetti, G. P., Arimori, K., Schuetz, E. G., & Schuetz, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11037 · Cited by 161 · see citing works
DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms
Clair, S. S., Giono, L. E., Varmeh, S., Resnick‐Silverman, L., Liu, W.-J., Padi, A., Dastidar, J., DaCosta, A., Mattia, M., & Manfredi, J. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.002 · Cited by 162 · see citing works
Koutsodontis, G., Tentes, I. K., Papakosta, P., Moustakas, A., & Kardassis, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104130200 · Cited by 159 · see citing works
Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157 · see citing works
Liu, Z., & Simpson, E. R. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9890 · Cited by 156 · see citing works
Inhibition of DNA Topoisomerase IIα Gene Expression by the p53 Tumor Suppressor
Wang, Q., Zambetti, G. P., & Suttle, D. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.389 · Cited by 149 · see citing works
Webster, N. J. G., Resnik, J. L., Reichart, D. B., Strauss, B. E., Haas, M., & Seely, B. L. (1996) · PubMed · Cited by 149 · see citing works
Tumor-Derived p53 Mutants Induce NF-κB2 Gene Expression
Scian, M. J., Stagliano, K. E., Anderson, M. A. E., Hassan, S., Bowman, M., Miles, M. F., Deb, S. P., & Deb, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10097-10110.2005 · Cited by 149 · see citing works
p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene Expression
Sun, Y., Sun, Y., Wenger, L., Rutter, J. L., Brinckerhoff, C., & Cheung, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11535 · Cited by 143 · see citing works
Nuclear Receptor-Mediated Transactivation Through Interaction with Sp Proteins
Safe, S. H., & Kim, K. (2004) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(04)77001-4 · Cited by 143 · see citing works
Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cells
Sinha-Datta, U., Horikawa, I., Michishita, E., Datta, A., Sigler-Nicot, J. C., Brown, M., Kazanji, M., Barrett, J. C., & Nicot, C. (2004) · Blood · doi:10.1182/blood-2003-12-4251 · Cited by 126 · see citing works
Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120 · see citing works
p53: A Cell Cycle Regulator Activated by DNA Damage
Selivanova, G., & Wiman, K. G. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60253-5 · Cited by 118 · see citing works
Modulation of Gene Expression by Tumor-Derived p53 Mutants
Scian, M. J., Stagliano, K. E., Ellis, M. A., Hassan, S., Bowman, M., Miles, M. F., Deb, S. P., & Deb, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1568 · Cited by 117 · see citing works
The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair
Müller‐Tidow, C., Ji, P., Diederichs, S., Potratz, J. C., Bäumer, N., Köhler, G., Cauvet, T., Choudary, C., van der Meer, T., Chan, W. Y. I., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8917-8928.2004 · Cited by 115 · see citing works
Zaky, A., Busso, C., Izumi, T., Chattopadhyay, R., Bassiouny, A., Mitra, S., & Bhakat, K. K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkm1173 · Cited by 111 · see citing works
p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism
Bist, A., Fielding, C. J., & Fielding, P. E. (2000) · Biochemistry · doi:10.1021/bi991721h · Cited by 104 · see citing works
Zhang, Q., Gutsch, D. E., & Kenney, S. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1929-1938.1994 · Cited by 104 · see citing works
Zhang, L., Kashanchi, F., Zhan, Q., Zhan, S., Brady, J. N., Fornace, A. J., Seth, P. K., & Helman, L. J. (1996) · PubMed · Cited by 102 · see citing works
Gualberto, A., & Baldwin, A. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19680 · Cited by 101 · see citing works
The (patho)physiological functions of the MRP family
Renes, J., de Vries, E. G. E., Jansen, P. L. M., & Müller, M. M. (2000) · Drug Resistance Updates · doi:10.1054/drup.2000.0156 · Cited by 100 · see citing works
Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene
Cohen, H. T., Bossone, S., Zhu, G., McDonald, G. A., & Sukhatme, V. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2901 · Cited by 100 · see citing works
Yan, C., Wang, H., & Boyd, D. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112069200 · Cited by 96 · see citing works
Sun, Y., Cheung, J. M., Martel‐Pelletier, J., Pelletier, J. P., Wenger, L., Altman, R. D., Howell, D. S., & Cheung, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11327 · Cited by 95 · see citing works
Bocangel, D., Sengupta, S., MITRA, S. P., & Bhakat, K. K. (2009) · PubMed · Cited by 94 · see citing works
Sp1-Mediated Transcription of the Werner Helicase Gene Is Modulated by Rb and p53
Yamabe, Y., Shimamoto, A., Goto, M., Yokota, J., Sugawara, M., & Furuichi, Y. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6191 · Cited by 91 · see citing works
The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication
Duan, L., Ozaki, I., Oakes, J. W., Taylor, J. P., Khalili, K., & Pomerantz, R. J. (1994) · Journal of Virology · doi:10.1128/jvi.68.7.4302-4313.1994 · Cited by 91 · see citing works
Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis
Ozbun, M. A., & Butel, J. S. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60252-3 · Cited by 89 · see citing works
Yang, J. J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.6.1117 · Cited by 86 · see citing works
Thornborrow, E. C., & Manfredi, J. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011643200 · Cited by 85 · see citing works
Regulation of Sp1 by cell cycle related proteins
Tapias, A., Ciudad, C. J., Roninson, I. B., & Noé, V. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6671 · Cited by 82 · see citing works
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening
Gunther, M., Laithier, M., & Brison, O. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007177623283 · Cited by 81 · see citing works
Role of Sp1 in cAMP-dependent Transcriptional Regulation of the Bovine CYP11A Gene
Ahlgren, R., Suske, G., Waterman, M. R., & Lund, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19422 · Cited by 78 · see citing works
Pietrzak, M., & Puzianowska‐Kuźnicka, M. (2008) · Biological Chemistry · doi:10.1515/bc.2008.039 · Cited by 74 · see citing works
Duriez, C., Falette, N., Audoynaud, C., Moyret-Lalle, C., Bensaad, K., Courtois, S., Wang, Q., Soussi, T., & Puisieux, A. (2002) · Gene · doi:10.1016/s0378-1119(01)00825-3 · Cited by 73 · see citing works
Liu, Z., & R. Simpson, E. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00036-2 · Cited by 71 · see citing works
Dittmer, J., Gégonne, A., Gitlin, S. D., Ghysdael, J., & Brady, J. N. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31821-5 · Cited by 71 · see citing works
D’Souza, S., Xin, H., Walter, S., & Choubey, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007155200 · Cited by 71 · see citing works
Gac, G. L., Estève, P., Férec, C., & Pradhan, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603724200 · Cited by 70 · see citing works
P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3
Zerrouqi, A., Pyrzynska, B., Febbraio, M., Brat, D. J., & Van Meir, E. G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci38596 · Cited by 70 · see citing works
Mutant p53 Forms a Complex with Sp1 on HIV-LTR DNA
Chicas, A., Molina, P. E., & Bargonetti, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3965 · Cited by 69 · see citing works
Regulation of multidrug resistance through the cAMP and EGF signalling pathways
Rohlff, C., & Glazer, R. I. (1995) · Cellular Signalling · doi:10.1016/0898-6568(95)00018-k · Cited by 69 · see citing works
Self-citationGoldsmith, M. E., Gudas, J. M., Schneider, E., & Cowan, K. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1894 · Cited by 69 · see citing works
Li, B., & Lee, M. Y. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101167200 · Cited by 65 · see citing works
p53 Homologue p63 Represses Epidermal Growth Factor Receptor Expression
Nishi, H., Senoo, M., Nishi, K., Murphy, B., Rikiyama, T., Matsumura, Y., Habu, S., & Johnson, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101241200 · Cited by 65 · see citing works
Infrequent mutations of the p53 gene in pulmonary carcinoid tumors.
Lohmann, D. R., FESSELER, B., Pütz, B., Reich, U., Böhm, J., Präuer, H. W., Wünsch, P. H., & Höfler, H. (1993) · PubMed · Cited by 65 · see citing works
Response of heat shock element within the human HSP70 promoter to mutated p53 genes.
Tsutsumi‐Ishii, Y., Tadokoro, K., Hanaoka, F., & Tsuchida, N. (1995) · PubMed · Cited by 64 · see citing works
Shen, L., Dean, N. M., & Glazer, R. I. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12039-1 · Cited by 64 · see citing works
Self-citationLead Exposure in Pheochromocytoma (PC12) Cells Alters Neural Differentiation and Sp1 DNA-Binding
Crumpton, T. L., Atkins, D. S., Zawia, N. H., & Barone, S. (2001) · NeuroToxicology · doi:10.1016/s0161-813x(00)00008-5 · Cited by 62 · see citing works
Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family
Kolesnikoff, N., Attema, J. L., Roslan, S., Bert, A. G., Schwarz, Q., Gregory, P. A., & Goodall, G. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529172 · Cited by 60 · see citing works
Persengiev, S. P., Raval, P., Rabinovitch, S., Millette, C. F., & Kilpatrick, D. L. (1996) · Endocrinology · doi:10.1210/en.137.2.638 · Cited by 60 · see citing works
Regulation of constitutive expression of mouse PTEN by the 5′-untranslated region
Han, B., Dong, Z., Liu, Y., Chen, Q., Hashimoto, K., & Zhang, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206783 · Cited by 58 · see citing works
p53-Dependent Transcriptional Control of Cellular Prion by Presenilins
Vincent, B., Sunyach, C., Orzechowski, H., George‐Hyslop, P. S., & Checler, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0789-09.2009 · Cited by 56 · see citing works
Ramaiah, M. J., Naushad, S. M., Ponnusamy, L., Arivazhagan, G., Sakthiprasad, V., & Pal‐Bhadra, M. (2017) · Gene · doi:10.1016/j.gene.2017.10.018 · Cited by 57 · see citing works
Sun, Y., Zeng, X., Wenger, L., Firestein, G. S., & Cheung, H. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20044 · Cited by 57 · see citing works
A comprehensive study of p53 protein
Patil, M. R., & Bihari, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30331 · Cited by 55 · see citing works
Torgeman, A., Mor‐Vaknin, N., Zelin, E., Ben-Aroya, Z., Löchelt, M., Flügel, R. M., & Aboud, M. (2001) · Virology · doi:10.1006/viro.2000.0779 · Cited by 54 · see citing works
Takada, N., Sanda, T., Okamoto, H., Yang, J., Asamitsu, K., Sarol, L. D. C., Kimura, G., Uranishi, H., Tetsuka, T., & Okamoto, T. (2002) · Journal of Virology · doi:10.1128/jvi.76.16.8019-8030.2002 · Cited by 53 · see citing works
Zhan, M., Yu, D., Liu, J., Hannay, J. A. F., & Pollock, R. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407450200 · Cited by 52 · see citing works
Benoît, V., Hellin, A., Huygen, S., GIELEN, J. E., Bours, V., & Merville, M.-P. (2000) · Oncogene · doi:10.1038/sj.onc.1203831 · Cited by 52 · see citing works
Gueven, N., Keating, K. E., Chen, P., Fukao, T., Khanna, K. K., Watters, D. J., Rodemann, H. P., & Lavin, M. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006190200 · Cited by 51 · see citing works
Kelavkar, U. P., & Badr, K. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4378 · Cited by 49 · see citing works
A Comparison of Apoptosis and Necrosis Induced by Hepatotoxins in HepG2 Cells
O’Brien, T. J., Babcock, G. F., Cornelius, J. R., Dingeldein, M., Talaska, G., Warshawsky, D., & Mitchell, K. R. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8917 · Cited by 49 · see citing works
Wang, F., Wang, W., & Safe, S. H. (1999) · Biochemistry · doi:10.1021/bi982578f · Cited by 49 · see citing works
The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression
van Bodegom, D., Saifudeen, Z. R., Dipp, S., Puri, S., Magenheimer, B. S., Calvet, J. P., & El-Dahr, S. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606510200 · Cited by 46 · see citing works
p53, proto-oncogene and rheumatoid arthritis
Sun, Y., & Cheung, H. S. (2002) · Seminars in Arthritis and Rheumatism · doi:10.1053/sarh.2002.31550 · Cited by 45 · see citing works
Subler, M. A., Martin, D. W., & Deb, S. (1994) · Journal of Virology · doi:10.1128/jvi.68.1.103-110.1994 · Cited by 45 · see citing works
BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53
Nie, E., Jin, X., Wu, W., Yu, T., Zhou, X., Zhi, T., Shi, Z., Zhang, J., Liu, N., & You, Y. (2016) · Scientific Reports · doi:10.1038/srep39743 · Cited by 44 · see citing works
Shen, L., & Glazer, R. I. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00045-8 · Cited by 39 · see citing works
Self-citationThe NF-Y/p53 liaison: Well beyond repression
Imbriano, C., Gnesutta, N., & Mantovani, R. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.11.001 · Cited by 38 · see citing works
Cheng, Y.-H., Chang, L. W., & Tsou, T. (2005) · Archives of Toxicology · doi:10.1007/s00204-005-0045-1 · Cited by 38 · see citing works
Regulation of p53 mediated transactivation by the β‐subunit of protein kinase CK2
Schuster, N., Prowald, A., Schneider, E., Scheidtmann, K., & Montenarh, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00273-2 · Cited by 37 · see citing works
Gualberto, A., Hixon, M. L., Finco, T. S., Perkins, N. D., Nabel, G. J., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3450 · Cited by 37 · see citing works
p53: Its Mutations and Their Impact on Transcription
Vaughan, C. A., Pearsall, I., Yeudall, W. A., Deb, S. P., & Deb, S. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_4 · Cited by 35 · see citing works
Dey, A., Atcha, I. A., & Bagchi, S. (1997) · Virology · doi:10.1006/viro.1996.8363 · Cited by 33 · see citing works
E2Fs and the Retinoblastoma Protein Family
Sardet, C., Cam, L. L., Fabbrizio, E., & Vidal, M. (1997) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8934-6_1 · Cited by 33 · see citing works
Tissue-specific p53 expression in the nervous system
Tendler, Y., Weisinger, G., Coleman, R., Diamond, E., Lischinsky, S., Kerner, H., Rotter, V., & Zinder, O. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00202-8 · Cited by 32 · see citing works
Wild-Type p53 Regulates Its Own Transcription in a Cell-Type Specific Manner
Hudson, J. M., Frade, R., & Bar‐Eli, M. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.759 · Cited by 29 · see citing works
Transcriptional involvement in neurotoxicity
Zawia, N. H. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00161-3 · Cited by 29 · see citing works
The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy
Milosavljević, V., Haddad, Y., Rodrigo, M. Á. M., Moulick, A., Polanska, H. H., Hynek, D., Heger, Z., Kopel, P., & Adam, V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163983 · Cited by 28 · see citing works
- Authors
- Borellini, F., & Glazer, R. I.
- Affiliations
- Georgetown University Medical Center (US)
- ORCID
- Glazer, R.I.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 268
- Issue
- 11
- Pages
- 7923-7928
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1547769073
- Cited by
- 147
- References
- 48
- Citations by year
- 2025: 1 · 2022: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca054231-03)
- National Cancer Institute (CA54231)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Sp1, p53, heterocomplexes, DNA binding, GM-CSF, erythroleukemia, TF-1 cell line, cell proliferation, growth regulation, apoptosis, growth arrest, transcription factor binding sites
- MeSH terms
- Base Sequence, Cell Division, Cell Nucleus, Chromatin, DNA-Binding Proteins, DNA, Neoplasm, Leukemia, Erythroblastic, Acute, Humans, Microscopy, Electron, Molecular Sequence Data, Oligodeoxyribonucleotides, Tumor Cells, Cultured, Tumor Suppressor Protein p53, Granulocyte-Macrophage Colony-Stimulating Factor, Sp1 Transcription Factor, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review