Cited by 198Chromosomal and Genetic VariationsGenome Rearrangement AlgorithmsGenomic variations and chromosomal abnormalities

Mobile elements inserted in the distant past have taken on important functions

Britten, Roy J.·1997·Gene

Abstract

Current evidence on the long-term evolutionary effect of insertion of sequence elements is reviewed. There are three criteria for inclusion of an example: (i) the element was inserted far in the past and thus the event is not a transient mutation; (ii) the element is a member of a large group of similar sequences; (iii) the element now serves a useful function. There are 21 examples from Drosophila, sea urchin, human and mouse genomes that meet these criteria. Taken together, these examples show that the insertion of sequence elements in the genome has been a significant source of regulatory variation in evolution.

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Crossref · 10.1016/s0378-1119(97)00399-5

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  • Some conserved ancestral repeats have apparently taken on critical functions that may help differentiate mammals from ancestral vertebrates.

    “some have apparently taken on critical functions that may help to differentiate mammals from ancestral vertebrates (Britten 1997;Jordan et al. 2003;van de Lagemaat et al. 2003).”
  • Transposable elements contain functional subunits that can be exapted and modified by the host genome, and they can mediate duplication of existing CNEs to distant genomic locations.

    “Transposable elements contain a variety of functional subunits that can be exapted and modified by the host genome 89,91 , and they can mediate duplication of existing CNEs to distant genomic locations through transduction or chimaerism 92 .”

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Authors
Britten, R. J.
Affiliations
California Institute of Technology (US)
Corresponding author
Britten, Roy J.
Venue
Gene
Publisher
Elsevier BV
Published
1997-12
Volume
205
Issue
1-2
Pages
177-182
ISSN
0378-1119 (ISSN-L)
OpenAlex
W1989728485
Cited by
198
References
41
Citations by year
2026: 1 · 2024: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 5
FWCI
21.08
Type
journal article
Language
en
Open access
closed
Locations
  • Gene (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
transposable elements, genome evolution, regulatory variation, Drosophila, sea urchins, human genome, mouse genome
MeSH terms
Animals, DNA Transposable Elements, Gene Expression Regulation, Humans, Retroviridae, Transcription, Genetic, Retroelements, Evolution, Molecular

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