Repetitive and Non-Repetitive DNA Sequences and a Speculation on the Origins of Evolutionary Novelty
Abstract
Recent experimental information on DNA sequence repetition is reviewed, and the significance of both repetitive and non-repetitive sequence considered. Included are a summary of data on the distribution of genome sizes in animals, new experiments on interspecific DNA homology, the distribution of sequence frequencies, and the interspersion of repetitive sequences within the genome. Aspects of the process of evolution are considered at the level of change in the DNA. the process by which novel structure and function could have arisen during evolution are considered speculatively in terms of the authors' gene regulation theory (Britten and Davidson, 1969).
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Mobile elements could have provided a major mechanism of gene regulatory network evolution.
“In summary, as previously speculated (Britten and Davidson, 1971), mobile elements could have provided a major mechanism of GRN evolution.”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Britten and Davidson, 1971
In “Proposals for the Origin of Evolutionary Novelty” (pp. 124–126), the paper speculates that genomic rearrangements could construct new regulatory networks, including by moving regulatory sequences to new locations. That supports the proposed link to regulatory-network evolution, but the passages describe chromosomal rearrangements and repetitive sequences, not mobile elements specifically as a major mechanism. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSuch changes in gene regulatory network operation cause changes in developmental process and ultimately in the body plan.
“This will cause changes in developmental process, and ultimately in the product of that process, the body plan (Britten and Davidson, 1971; Davidson and Erwin, 2006; Erwin and Davidson, 2009).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Britten and Davidson, 1971
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Research works printed but not linked: 3
- BIER, K., w. KUNZ, and D. RIBBERT. 1969. Insect oogenesis with and without lampbrush chromo somes. In C. D. Darlington and K. R. Lewis (eds.), Chromosomes Today, Vol. 2, p. 107-115. Plenum Press, N.Y.
- 1969b. Repeated DNA and transcription. In E. W. Hanly (ed.), Problems in Biology: RNA in Development, p. 187-216. University of Utah Press, Salt Lake City.
- --, and --. 1969a. Repetition of nucleotide sequences in chromosomal DNA. In A. Lima de-Faria (ed.), Handbook of Molecular Cy-
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- Authors
- Britten, R. J., & Davidson, E. H.
- Venue
- The Quarterly Review of Biology
- Publisher
- University of Chicago Press
- Published
- 1971-06
- Volume
- 46
- Issue
- 2
- Pages
- 111-138
- ISSN
- 0033-5770 (ISSN-L)
- 1539-7718
- OpenAlex
- W2012036024
- Cited by
- 789
- References
- 0
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 17 · 2023: 8 · 2022: 9 · 2021: 17 · 2020: 20 · 2019: 17 · 2018: 19 · 2017: 15 · 2016: 25 · 2015: 22 · 2014: 27 · 2013: 15 · 2012: 13
- FWCI
- 35.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Quarterly Review of Biology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- repetitive DNA, interspersed repetitive elements, DNA sequence evolution
- MeSH terms
- Base Sequence, DNA, Biological Evolution, Genetic Code, Models, Chemical, Molecular Biology, RNA
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