Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor
Abstract
Glycine has been shown to modulate N-methyl-D-aspartate (NMDA) subclass of acidic amino acid receptors which have been implicated in learning and memory. We report that d-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. Mice were trained on a footshock avoidance task. Immediately after training DCS was administered (2.5 to 50 mg/kg s.c.). When retention was tested a week later, 20 mg/kg facilitated retention the best with lower and higher doses be less effective in weakly trained young mice. DCS also facilitated retention in 'senescence-accelerated mice' in which impairment of learning and memory increases with age. DCS had to be administered at higher doses to improve retention as impairment of learning and memory increased.
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Various transgenic and pharmacological approaches that augment NMDAR signaling increase learning and memory in mice.
“Various transgenic and pharmacological approaches that augment NMDAR signaling have been found to increase learning and memory in mice, for example, NR2B overexpression and application of NMDAR partial agonist, D-cycloserine (79,80).”
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- Authors
- Flood, J. F., Morley, J. E., & Lanthorn, T. H.
- Affiliations
- St. Louis VA Medical Center (US)
- Saint Louis University Hospital (US)
- Corresponding author
- Flood, James F.
- ORCID
- Morley, John E.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 221
- Issue
- 2-3
- Pages
- 249-254
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2069839495
- Cited by
- 153
- References
- 1
- Citations by year
- 2024: 2 · 2023: 12 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag009321-04)
- National Institute on Aging (AG 09321)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- D-cycloserine, NMDA receptor, memory consolidation, retention, footshock avoidance, senescence-accelerated mice, age-related memory impairment, learning and memory
- MeSH terms
- Age Factors, Animals, Cycloserine, Dose-Response Relationship, Drug, Male, Memory, Retention, Psychology, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, Receptors, Glycine, Mice
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