Cited by 194T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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CD28 Expression in T Cell Aging and Human Longevity

Boucher, Nathalie, Dufeu-Duchesne, Tania, Vicaut, Eric, Farge, Dominique, Effros, Rita B, Schächter, François·1998·Experimental Gerontology

DOI 10.1016/s0531-5565(97)00132-0

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Abstract

Functional decrements of the immune system have a major contribution to aging and age-related diseases. Here, we further characterize the decline in proportion of CD28-positive T cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8+ subset of T cells. This decline accounts largely for the age-related diminution of T cell responsiveness to mitogenic signals. CD28 expression is modulated in T cell cultures in a growth-related fashion and this modulation is dampened in cultures from centenarians. We propose that the decrease in CD28 expression reflects a compensatory adaptation of the immune system during aging in the face of chronic stimulation.

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Macián, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_112-1
The Complex Relationship Between Nutrition and Immunosenescence
Larbi, A., Lesourd, B., & Fülöp, T. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_65-1
Chronic stress and ageing : effects on immune function
Vitlić, A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Somatic Cells – Growth and Expansion Potential of T Lymphocytes
Effros, R. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00075-5
Self-citation
Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infection
Fauce, S. R., & Effros, R. B. (2008) · Springer eBooks · doi:10.1007/978-0-387-76842-7_4
Self-citation
References
(2021) · Wiley eBooks · doi:10.1002/9781119611288.refs
Generation and Gene Expression of CD28−CD8 T Cells in Human
Kim, J., & Weng, N. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_17
T-Cell Cycle and Immunosenescence: Role of Aging in the T-Cell Proliferative Behavior and Status Quo Maintenance
Witkowski, J. M., & Fülöp, T. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_13-1
Autophagy and T Cell Aging
Macián, F. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_112
T Cell Cycle and Immunosenescence: Role of Aging in the T Cell Proliferative Behavior and Status Quo Maintenance
Witkowski, J. M., & Fülöp, T. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_13
Generation and Gene Expression of CD28−CD8 T Cells in Human
Kim, J., & Weng, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_17-1
Phenotypic frailty in people living with HIV is not correlated with age or immunosenescence
Klotz, S. A., Egurrola, C., Love, M., et al. (2022) · International Journal of STD & AIDS · doi:10.1177/09564624221091455
“In aging uninfected individuals, there is a major decline in CD4 and CD8 cells expressing CD28, in itself an expression of immunosenescence.(8) In this work, we measure physical frailty as well as immunological markers of aging in a group of older, mostly men, on long-term, suppressive ART.”
Background
Faculty Opinions recommendation of CD28 costimulation: from mechanism to therapy.
Tuosto, L. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726363559.793546230
Genetics of Survival
Schächter, F. (2000) · Springer eBooks · doi:10.1007/978-3-642-56947-0_1
Self-citation
Somatic Cells: Growth and Expansion Potential of T Lymphocytes
Effros, R. B. (2008) · Elsevier eBooks · doi:10.1016/b978-012369410-2.50028-0
Self-citation
T cell exhaustion and aging: is replicative senescence relevant?
Effros, R. B. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13016-1
Self-citation
Additional file 1 of Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
Semelka, C., DeWitt, M. E., Blevins, M. W., Holbrook, B. C., Sanders, J. W., & Alexander‐Miller, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26561866
Évolution des mécanismes de production et de régulation du sommeil paradoxale au cours du vieillissement chez le rat : implication de la NO-synthase inductible : conséquences sur la réponse au stress : rétablissement de la réponse au stress par un antidépresseur
Descamps, A. (2009) · theses.fr (ABES) · doi:10.70675/b1d785e5zdc1az4353z958czf0e16102bc0d
CD28 : nouvelles données sur un récepteur majeur de la costimulation lymphocytaire T
Morin, S. O. (2017) · theses.fr (ABES) · doi:10.70675/cb01635fz2f63z43e2zad0cz210485c4c5cf
Rôle des virus EBV et VIH dans la formation de la translocation chromosomique t(8;14) du Lymphome de Burkitt
Sall, F. B. (2021) · theses.fr (ABES) · doi:10.70675/4ade78c4z0bf6z4533zb4a6z084522268290
From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes
Effros, R. B. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50005-9
Self-citation

Authors: Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F.
Affiliations: Fondation Jean Dausset-CEPH (FR)
Hôpital Saint-Louis (FR)
University of California, Los Angeles (US)
Corresponding author: Schächter, François
ORCID: Boucher, Nathalie
Farge, Dominique
Effros, Rita B
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 1998-05
Volume: 33
Issue: 3
Pages: 267-282
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/s0531-5565(97)00132-0
OpenAlex: W1973076242
Semantic Scholar: 56c903c155c96dbf324ec10a879404754b4df8af
Cited by: 194
References: 65
Citations by year: 2025: 3 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
FWCI: 2.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: CD28, T cell senescence, centenarians, human longevity, CD8+ T cells, immunosenescence, T cell responsiveness, mitogen stimulation, chronic immune stimulation, CD4+ T cells
MeSH terms: Adult, Aged, Aged, 80 and over, Blood Cells, Cell Division, Cells, Cultured, Humans, Longevity, T-Lymphocytes, Cellular Senescence, CD28 Antigens

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CD28 Expression in T Cell Aging and Human Longevity

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