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Cited by 194T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

The DOI matches its Crossref record; 63 of the 65 references it cites were found in a registry or an index.

CD28 Expression in T Cell Aging and Human Longevity

Boucher, Nathalie, Dufeu-Duchesne, Tania, Vicaut, Eric, Farge, Dominique, Effros, Rita B, Schächter, François·1998·Experimental Gerontology
DOI 10.1016/s0531-5565(97)00132-0
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Abstract

Functional decrements of the immune system have a major contribution to aging and age-related diseases. Here, we further characterize the decline in proportion of CD28-positive T cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8+ subset of T cells. This decline accounts largely for the age-related diminution of T cell responsiveness to mitogenic signals. CD28 expression is modulated in T cell cultures in a growth-related fashion and this modulation is dampened in cultures from centenarians. We propose that the decrease in CD28 expression reflects a compensatory adaptation of the immune system during aging in the face of chronic stimulation.

Overview

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Crossref · 10.1016/s0531-5565(97)00132-0

Cites

63 of 63 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Butcher, 1990, Cellular and molecular mechanisms that direct leukocyte traffic, Am. J. Pathol., 136, 3
  2. Murasko, 1988, Association of lack of mitogen-induced lymphocyte proliferation with increased mortality in the elderly, Aging Immunol. Infect. Dis., 1, 1
  3. Schächter, 1995, Sénescence cellulaire et survie des lymphocytes T, C. R. Acad. Sci. Paris, 318, 563

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Metadata

Authors
Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F.
Affiliations
  • Fondation Jean Dausset-CEPH (FR)
  • Hôpital Saint-Louis (FR)
  • University of California, Los Angeles (US)
Corresponding author
Schächter, François
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
1998-05
Volume
33
Issue
3
Pages
267-282
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/s0531-5565(97)00132-0
OpenAlex
W1973076242
Semantic Scholar
56c903c155c96dbf324ec10a879404754b4df8af
Cited by
194
References
65
Citations by year
2025: 3 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords
CD28, T cell senescence, centenarians, human longevity, CD8+ T cells, immunosenescence, T cell responsiveness, mitogen stimulation, chronic immune stimulation, CD4+ T cells
MeSH terms
Adult, Aged, Aged, 80 and over, Blood Cells, Cell Division, Cells, Cultured, Humans, Longevity, T-Lymphocytes, Cellular Senescence, CD28 Antigens

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