The DOI matches its Crossref record; 63 of the 65 references it cites were found in a registry or an index.
CD28 Expression in T Cell Aging and Human Longevity
Abstract
Functional decrements of the immune system have a major contribution to aging and age-related diseases. Here, we further characterize the decline in proportion of CD28-positive T cells previously identified in centenarians. Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens. The significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8+ subset of T cells. This decline accounts largely for the age-related diminution of T cell responsiveness to mitogenic signals. CD28 expression is modulated in T cell cultures in a growth-related fashion and this modulation is dampened in cultures from centenarians. We propose that the decrease in CD28 expression reflects a compensatory adaptation of the immune system during aging in the face of chronic stimulation.
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“These changes can include an involuted thymus235, fewer naive B and T cells236, diminished T cell receptor diversity237, higher susceptibility to T cell apoptosis238 and reduced expression of crucial receptors such as CD28 on cytotoxic CD8+ T cells239.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [239]
Citations
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Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334
“As humans age, the immune system becomes senescent (Boucher et al., 1998; Wikby, Johansson, Ferguson, & Olsson, 1994).”
BackgroundmRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555
CD28 Costimulation: From Mechanism to Therapy
Esensten, J. H., Helou, Y. A., Chopra, G., Weiss, A., & Bluestone, J. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.020 · Cited by 937
“These cells represent a population of antigen-experienced cells that might have either pro- or anti-inflammatory characteristics (Boucher et al., 1998; Strioga et al., 2011).”
BackgroundThe aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Effros, R. B., Fletcher, C. V., Gebo, K., Halter, J. B., Hazzard, W. R., Horne, F. M., Huebner, R. E., Janoff, E. N., Justice, A. C., Kuritzkes, D., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/590150 · Cited by 539
“The percentage of CD4+ T cells that are CD28− rarely exceeds 10% in older individuals, whereas CD28− T cells can represent >70% of CD8+ T cells during very advanced age [47].”
Self-citation
Metadata
- Authors
- Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F.
- Affiliations
- Fondation Jean Dausset-CEPH (FR)
- Hôpital Saint-Louis (FR)
- University of California, Los Angeles (US)
- Corresponding author
- Schächter, François
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 33
- Issue
- 3
- Pages
- 267-282
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W1973076242
- Semantic Scholar
- 56c903c155c96dbf324ec10a879404754b4df8af
- Cited by
- 194
- References
- 65
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- CD28, T cell senescence, centenarians, human longevity, CD8+ T cells, immunosenescence, T cell responsiveness, mitogen stimulation, chronic immune stimulation, CD4+ T cells
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Cells, Cell Division, Cells, Cultured, Humans, Longevity, T-Lymphocytes, Cellular Senescence, CD28 Antigens
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