Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology
Abstract
Samples from human brains were examined with both stereologic methods for neuronal counting and high resolution magic angle spinning (HRMAS) proton magnetic resonance spectroscopy (1HMRS) for quantification of cellular metabolites. A statistically significant linear correlation between neuronal density and the concentration of N-acetylaspartate (NAA) in the superior temporal sulcus (STS) area was observed. Although NAA has been widely utilized as a neuronal marker in in vivo MRS, an emerging sub-discipline of diagnostic neuroradiology, the experimental proof of the unilateral relationship between NAA and neurons has yet to be confirmed. The observed correlation provides experimental evidence that NAA concentration is proportional to the neuronal density. Metabolite ratios measured from the STS area were compared to those from frontal association cortex for their sensitivities in differentiating Alzheimer disease brains from control brains.
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SS HRMAS-NMR facilitates sample preparation and has been used for metabolomic screening of cancer tissue, neurons, metabolic syndrome, and plants.
“This facilitates the sample preparation and has been used for the metabolomic screening of, e.g., cancer tissue,136,137 metabolite screening in neurons,138 metabolic syndrome,139 plants140 or other.”
From Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products (2024) · cites this paper as [138]
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(2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.786
- Authors
- Cheng, L. L., Newell, K., Mallory, A. E., Hyman, B. T., & Gonzalez, R. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Cheng, Leo Ling
- Venue
- Magnetic Resonance Imaging
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 20
- Issue
- 7
- Pages
- 527-533
- ISSN
- 0730-725X (ISSN-L)
- OpenAlex
- W1973467448
- Cited by
- 77
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r29ca077727-01a1, 5r01rr013213-04)
- National Institute on Aging (AG-08487, P01AG05134)
- National Cancer Institute (CA77727)
- National Institute of Neurological Disorders and Stroke (NS 34626, R01NS034626)
- National Center for Research Resources (RR13213)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Keywords
- Alzheimer's disease, neuronal density, N-acetylaspartate, stereology, superior temporal sulcus, frontal association cortex, brain metabolite ratios, ex vivo brain tissue
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Aspartic Acid, Choline, Creatine, Humans, Neurons, Magnetic Resonance Spectroscopy, Least-Squares Analysis, Case-Control Studies, In Vitro Techniques
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