Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism
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Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired social and emotional skills, the anatomical substrate of which is still unknown. In this study, we compared a group of 14 high-functioning ASD adults with a group of controls matched for sex, age, intelligence quotient, and handedness. We used an automated technique of analysis that accurately measures the thickness of the cerebral cortex and generates cross-subject statistics in a coordinate system based on cortical anatomy. We found local decreases of gray matter in the ASD group in areas belonging to the mirror neuron system (MNS), argued to be the basis of empathic behavior. Cortical thinning of the MNS was correlated with ASD symptom severity. Cortical thinning was also observed in areas involved in emotion recognition and social cognition. These findings suggest that the social and emotional deficits characteristic of autism may reflect abnormal thinning of the MNS and the broader network of cortical areas subserving social cognition.
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These difficulties have been associated with anatomical and functional differences in the empathy network.
“These difficulties have been associated with anatomical and functional differences in the empathy network5–10.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [9]
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- Authors
- Hadjikhani, N., Joseph, R. M., Snyder, J., & Tager-Flusberg, H.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Hadjikhani, Nouchine
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-23
- Volume
- 16
- Issue
- 9
- Pages
- 1276-1282
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2112023300
- Cited by
- 554
- References
- 123
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 16 · 2022: 17 · 2021: 23 · 2020: 14 · 2019: 21 · 2018: 29 · 2017: 25 · 2016: 29 · 2015: 46 · 2014: 42 · 2013: 39 · 2012: 53
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Cerebral Cortex (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (P01/U19 DC 03610, U19DC003610)
- National Institute of Neurological Disorders and Stroke (R01 NS 44824-01, R01NS044824)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, mirror neuron system, social cognition, cortical thinning, gray matter, emotion recognition, empathic behavior, symptom severity, high-functioning adults
- MeSH terms
- Adult, Autistic Disorder, Cerebral Cortex, Cognition, Empathy, Humans, Interpersonal Relations, Male, Nerve Net, Neural Pathways, Neurons, Social Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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