The DOI matches its Crossref record; 189 of the 192 references it cites were found in a registry or an index.
Visual dysfunction, neurodegenerative diseases, and aging
Abstract
The four most common sight-threatening conditions in older adults in North America are cataract, ARM, glaucoma, and diabetic retinopathy. Even in their moderate stages, these conditions cause visual sensory impairments and reductions in health-related quality of life, including difficulties in daily tasks and psychosocial problems. Many older adults are free from these conditions, yet still experience a variety of visual perceptual problems resulting from aging-related changes in the optics of the eye and degeneration of the visual neural pathways. These problems consist of impairments in visual acuity, contrast sensitivity, color discrimination, temporal sensitivity, motion perception, peripheral visual field sensitivity, and visual processing speed. PD causes a progressive loss of dopaminergic cells predominantly in the retina and possibly in other areas of the visual system. This retinal dopamine deficiency produces selective spatial-temporal abnormalities in retinal ganglion cell function, probably arising from altered receptive field organization in the PD retina. The cortical degeneration characteristics of AD, including neurofibrillary tangles and neuritic plaques, also are present in the visual cortical areas, especially in the visual association areas. The most prominent electrophysiologic change in AD is a delay in the P2 component of the flash VEP. Deficits in higher-order visual abilities typically are compromised in AD, including problems with visual attention, perceiving structure from motion, visual memory, visual learning, reading, and object and face perception. There have been reports of a visual variant of AD in which these types of visual problems are the initial and most prominent signs of the disease. Visual sensory impairments (e.g., contrast sensitivity or achromatopsia) also have been reported but are believed more reflective of cortical disturbances than of AD-associated optic neuropathy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“visual attention and control of visual short-term memory decline as a result of neurodegenerative processes that occur with ageing, MCI, and AD [51,52,53]”
From Designing ICTs for Users with Mild Cognitive Impairment: A Usability Study (2020) · cites this paper as [52]
Citations
Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Handbook of Sensory Physiology
Sanders, M. D. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.111-c · Cited by 7,166
Berti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190
Handbook of the Psychology of Aging
Schaie, K. W., Willis, S. L., Knight, B. G., & Park, D. C. (2016) · Elsevier eBooks · doi:10.1016/c2012-0-07221-3 · Cited by 3,440
Number of people with glaucoma worldwide.
Quigley, H. A. (1996) · British Journal of Ophthalmology · doi:10.1136/bjo.80.5.389 · Cited by 3,054
Development of the 25-list-item National Eye Institute Visual Function Questionnaire
Mangione, C. M. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.7.1050 · Cited by 2,230
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845
Handbook of the Psychology of Aging
(1986) · Journal of Gerontology · doi:10.1093/geronj/41.2.296 · Cited by 1,557
Early Photocoagulation for Diabetic Retinopathy
* (1991) · Ophthalmology · doi:10.1016/s0161-6420(13)38011-7 · Cited by 1,548
Research works printed but not linked: 14
- Owsley, 1990, A comparison of the Regan Low-Contrast Letter Charts and contrast sensitivity testing in older patients, Clin Vis Scie, 5, 325
- Weale, 1975, Senile changes in vision acuity, Trans Ophthalmol Soc UK, 95, 36
- Bodis-Wollner, 1980, Contrast sensitivity measurement in clinical diagnosis, vol. 1, 373
- Haegerstrom-Portnoy, 1997, The SKILL card: an acuity test of reduced luminance and contrast, Invest Ophthalmol Vis Sci, 38, 207
- Rubin, 1997, A comprehensive assessment of visual impairment in a population of older Americans, Invest Ophthalmol Vis Sci, 38, 557
- Lakowski, 1958, Age and color vision, Adv Sci, 15, 231
- Ohta, 1976, Colour perception changes with age, Mod Probl Ophthalmol, 17, 345
- Iudice, 1980, The electroretinogram in Parkinson's disease. Research communications in psychology, Psychiatry and Behavior, 5, 283
- Ellis, 1987, Electroretinographic abnormalities in idiopathic Parkinson's disease and the effect of levodopa administration, Cin Vis Sci, 1, 347
- Murayama, 1989, Effects of L-Dopa on electroretinographic responses and pattern visual evoked potentials in juvenile Parkinsonism, Clin Vis Sci, 4, 265
- Coben, 1977, The effect of aging and of dimming the stimulus upon the visual evoked response to reversing checks in man, Electroencephalogr Clin Neurophysiol, 43, 559
- Gilmore, 1994, Motion perception and Alzheimer's disease, J Gerontol Psychol Sci, 49, P52, 10.1093/geronj/49.2.P52 · DOI
- Damasio, 1985, Disorders of complex visual processing: agnosias, achromatopsias, Balint's syndrome and related difficulties of orientation and construction, vol. 26, 259
- Wright, 1986, The flash and pattern VEP as a diagnostic indicator of dementia, Doc Ophthalmol, 62, 89, 10.1007/BF00140551 · DOI
Cited by
Sorted by citations
Items 201–226 of 226
Morgia, C. L., Ross‐Cisneros, F. N., Hannibal, J., Sadun, A. A., Carelli, V., & Montagna, P. (2012) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna)
Veilleux, C. C. (2016) · Texas ScholarWorks (Texas Digital Library) · doi:10.15781/t24j7g
Study of Correlation of Retinal Layer Thickness with Duration and Severity of Parkinson’s Disease
Student, I. Y. D. M. N., & Jadhav, D. K. B. (2017) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v5i6.220
Evidence of Asymptomatic Visual Losses after Surgical Repair of Cerebral Aneurysm
Bastos, A. M., Rodrigues, A. R., Côrtes, M. I. T., Lacerda, E. M. D. C. B., Lima, M. G., Teixeira, C. E. C., & Silveira, L. C. L. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00487
Impact of Surgeon’s Experience on Surgical Outcomes in Colorectal Surgery
Holmer, C., Sanftleben, A. E., Kreis, M. E., & Gröne, J. (2018) · Indian Journal of Surgery · doi:10.1007/s12262-018-1784-6
Hogg, R. E. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7506-8816-1.50027-6
The Partially Sighted Older Computer User: Assessing the Ease of Use of Two Input Devices
van den Brink, B. K. (2012)
Understanding age-triggered cognitive assessments of late-career physicians
Monico, E., Allusson, V., Calise, A., & Allusson, V. R. C. (2019) · Journal of Hospital Administration · doi:10.5430/jha.v8n5p26
Functional activation during the stroop task in normal older adults & MCI
Puente, A. N. (2012)
Moloodi, A., Rezaie, H., Khademi, B., Chakrabarti, P., Chakrabarti, T., Kateb, B., & Nami, M. (2021) · doi:10.31235/osf.io/ksc9e
Nájera, F. C., Papaqui-Hernández, J., Fierro, I., García‐Pando, A. C., & Alba‐Leonel, A. (2022) · Revista CONAMED · doi:10.35366/108483
Rowley, C., & Cook, J. (2022) · The Neuropsychologist · doi:10.53841/bpsneur.2022.1.14.8
Marefat, H., Vahabi, Z., Afzalian, N., Khanbagi, M., Karimi, H., Ebrahiminia, F., Kalafatis, C., Modarres, M. H., & Khaligh‐Razavi, S. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230132
McIlwaine, S. G., & Carroll, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00039-6
Tea catechins and visual motion processing
Sugita, Y. (2024) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-443-14158-4.00075-0
Pizzi, E., Gornati, S. V., Stabilini, S., Brambilla, D., Mercurio, C., Russ, H., Parsons, C. G., & Mazzanti, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.21.634046
Can a doctor be too old to practice medicine?
Eong, J. T. W. A. (2025) · Frontiers in Health Services · doi:10.3389/frhs.2025.1521832
Chen, P., Ren, T., Yang, F., Yang, Y., Jia, X., & Wang, W. (2025) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2025.111310
Lei, Y., Xu, L., Cai, Y., Xin, Q., & Meng, L. (2026) · BMC Psychology · doi:10.1186/s40359-026-04451-3
Self images: an empirical enquiry into Rembrandt’s self-portraits
Bettelheim, E. C., Liu, J., Dazzan, P., & Turkheimer, F. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1631373
Maximum likelihood estimation of perceptual differences in sorting tasks
Liu, Y., Li, H., Xiang, Y., Zhou, M., Li, Q., Yu, H., Ejima, Y., Takahashi, S., Yang, J., Bai, B., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349396
Huang, Z., Dekker, T. M., Crutch, S. J., Yong, K. X. X., & Greenwood, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.18.725904
Adsit, L. M., Cekada, K., & Smith, I. T. (2026) · iScience · doi:10.1016/j.isci.2026.117187
Heggenberger, A., Leisge, K., & Schaefer, S. (2026) · Experimental Aging Research · doi:10.1080/0361073x.2026.2703931 · Cited by 1
Metadata
- Authors
- Jackson, G. R., & Owsley, C.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Jackson, Gregory R
- ORCID
- Owsley, Cynthia
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 21
- Issue
- 3
- Pages
- 709-728
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W2069089682
- Cited by
- 226
- References
- 192
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 17
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01 AG 04212, R01AG004212)
- National Eye Institute (R21 EY 14071, R21EY014071)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- visual dysfunction, aging, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, cataract, age-related macular degeneration, glaucoma, diabetic retinopathy, visual perception, contrast sensitivity, color vision, motion perception, visual field sensitivity, visual processing speed, retinal ganglion cells, dopamine deficiency, flash visual evoked potentials, visual attention, achromatopsia, optic neuropathy
- MeSH terms
- Age Factors, Aged, Aging, Alzheimer Disease, Humans, Parkinson Disease, Perceptual Disorders, Visual Acuity, Visual Perception, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
