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Cited by 226Dementia and Cognitive Impairment ResearchVisual perception and processing mechanismsRetinal Diseases and Treatments

The DOI matches its Crossref record; 189 of the 192 references it cites were found in a registry or an index.

Visual dysfunction, neurodegenerative diseases, and aging

Jackson, Gregory R, Owsley, Cynthia·2003·Neurologic Clinics
DOI 10.1016/s0733-8619(02)00107-x
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Abstract

The four most common sight-threatening conditions in older adults in North America are cataract, ARM, glaucoma, and diabetic retinopathy. Even in their moderate stages, these conditions cause visual sensory impairments and reductions in health-related quality of life, including difficulties in daily tasks and psychosocial problems. Many older adults are free from these conditions, yet still experience a variety of visual perceptual problems resulting from aging-related changes in the optics of the eye and degeneration of the visual neural pathways. These problems consist of impairments in visual acuity, contrast sensitivity, color discrimination, temporal sensitivity, motion perception, peripheral visual field sensitivity, and visual processing speed. PD causes a progressive loss of dopaminergic cells predominantly in the retina and possibly in other areas of the visual system. This retinal dopamine deficiency produces selective spatial-temporal abnormalities in retinal ganglion cell function, probably arising from altered receptive field organization in the PD retina. The cortical degeneration characteristics of AD, including neurofibrillary tangles and neuritic plaques, also are present in the visual cortical areas, especially in the visual association areas. The most prominent electrophysiologic change in AD is a delay in the P2 component of the flash VEP. Deficits in higher-order visual abilities typically are compromised in AD, including problems with visual attention, perceiving structure from motion, visual memory, visual learning, reading, and object and face perception. There have been reports of a visual variant of AD in which these types of visual problems are the initial and most prominent signs of the disease. Visual sensory impairments (e.g., contrast sensitivity or achromatopsia) also have been reported but are believed more reflective of cortical disturbances than of AD-associated optic neuropathy.

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Citations

Cites

Research works printed but not linked: 14

  1. Owsley, 1990, A comparison of the Regan Low-Contrast Letter Charts and contrast sensitivity testing in older patients, Clin Vis Scie, 5, 325
  2. Weale, 1975, Senile changes in vision acuity, Trans Ophthalmol Soc UK, 95, 36
  3. Bodis-Wollner, 1980, Contrast sensitivity measurement in clinical diagnosis, vol. 1, 373
  4. Haegerstrom-Portnoy, 1997, The SKILL card: an acuity test of reduced luminance and contrast, Invest Ophthalmol Vis Sci, 38, 207
  5. Rubin, 1997, A comprehensive assessment of visual impairment in a population of older Americans, Invest Ophthalmol Vis Sci, 38, 557
  6. Lakowski, 1958, Age and color vision, Adv Sci, 15, 231
  7. Ohta, 1976, Colour perception changes with age, Mod Probl Ophthalmol, 17, 345
  8. Iudice, 1980, The electroretinogram in Parkinson's disease. Research communications in psychology, Psychiatry and Behavior, 5, 283
  9. Ellis, 1987, Electroretinographic abnormalities in idiopathic Parkinson's disease and the effect of levodopa administration, Cin Vis Sci, 1, 347
  10. Murayama, 1989, Effects of L-Dopa on electroretinographic responses and pattern visual evoked potentials in juvenile Parkinsonism, Clin Vis Sci, 4, 265
  11. Coben, 1977, The effect of aging and of dimming the stimulus upon the visual evoked response to reversing checks in man, Electroencephalogr Clin Neurophysiol, 43, 559
  12. Gilmore, 1994, Motion perception and Alzheimer's disease, J Gerontol Psychol Sci, 49, P52, 10.1093/geronj/49.2.P52 · DOI
  13. Damasio, 1985, Disorders of complex visual processing: agnosias, achromatopsias, Balint's syndrome and related difficulties of orientation and construction, vol. 26, 259
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Metadata

Authors
Jackson, G. R., & Owsley, C.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Jackson, Gregory R
ORCID
Owsley, Cynthia
Venue
Neurologic Clinics
Publisher
Elsevier BV
Published
2003-08
Volume
21
Issue
3
Pages
709-728
ISSN
0733-8619 (ISSN-L)
DOI
10.1016/s0733-8619(02)00107-x
OpenAlex
W2069089682
Cited by
226
References
192
Citations by year
2026: 6 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 17
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurologic Clinics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01 AG 04212, R01AG004212)
  • National Eye Institute (R21 EY 14071, R21EY014071)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords
visual dysfunction, aging, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, cataract, age-related macular degeneration, glaucoma, diabetic retinopathy, visual perception, contrast sensitivity, color vision, motion perception, visual field sensitivity, visual processing speed, retinal ganglion cells, dopamine deficiency, flash visual evoked potentials, visual attention, achromatopsia, optic neuropathy
MeSH terms
Age Factors, Aged, Aging, Alzheimer Disease, Humans, Parkinson Disease, Perceptual Disorders, Visual Acuity, Visual Perception, Neurodegenerative Diseases

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