Obesity and dyslipidemia
Abstract
The primary dyslipidemia related to obesity is characterized by increased triglycerides, decreased HDL levels, and abnormal LDL composition. Much work has been done to elucidate the pathogenesis of the dyslipidemia of obesity, which seems to be closely related to insulin resistance in obese individuals; however, more studies in humans are needed to further understand the metabolic mechanisms underlying the changes, and to distinguish between the roles of insulin resistance and body fat in the lipoprotein changes. The dyslipidemia associated with obesity no doubt plays a major role in the development of atherosclerosis and CVD in obese individuals. All of the components of the dyslipidemia, including higher triglycerides, decreased HDL levels, and increased small, dense LDL particles, have been shown to be atherogenic. Weight loss and exercise, even if they do not result in normalization of body weight, can improve this dyslipidemia and thus reduce CVD risk. In addition, obese individuals should be targeted for intense lipid-lowering therapy, when necessary.
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In US adults, 27% have hypertension and 31% have prehypertension according to NHANES 1999-2000.
“According to the most recent National Health and Nutrition Examination Survey (NHANES) (1999 -2000), 27% of adult Americans have hypertension (systolic BP Ն140 mm Hg, diastolic BP Ն90 mm Hg, or use of antihypertensive medication), and another 31% have prehypertension.20”
From Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee (2006) · cites this paper as [20]
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Mechanisms linking obesity with cardiovascular disease
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- Authors
- Howard, B. V., Ruotolo, G., & Robbins, D. C.
- Affiliations
- MedStar Health Research Institute (US)
- Eli Lilly (United States) (US)
- Corresponding author
- Howard, Barbara V
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 32
- Issue
- 4
- Pages
- 855-867
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W1970434966
- Cited by
- 318
- References
- 1
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 25 · 2021: 24 · 2020: 17 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 21 · 2012: 25
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- obesity, dyslipidemia, insulin resistance, hypertriglyceridemia, low HDL cholesterol, small dense LDL, atherosclerosis, cardiovascular risk, weight loss, physical activity, lipid-lowering therapy, lipoprotein metabolism
- MeSH terms
- Adult, Cardiovascular Diseases, Female, Humans, Hyperlipidemias, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Nutrition Surveys, Obesity, Triglycerides, Body Mass Index, Racial Groups
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