DIFFERENT ROLES FOR ANDROGENS AND ESTROGENS IN THE SUSCEPTIBILITY TO AUTOIMMUNE RHEUMATIC DISEASES

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224 · see citing works

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works

Immune-neuro-endocrine interactions: facts and hypotheses.

BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564 · see citing works

The Pathophysiologic Roles of Interleukin-6 in Human Disease

Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works

Interactions between the Hypothalamic-Pituitary-Adrenal Axis and the Female Reproductive System: Clinical Implications

Chrousos, G. P., Torpy, D. J., & Gold, P. W. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-3-199808010-00012 · Cited by 707 · see citing works

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells.

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Spelsberg, T. C., & Riggs, B. L. (1999) · Endocrinology · doi:10.1210/endo.140.9.7131 · Cited by 692 · see citing works

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

Girasole, G., Jilka, R. L., Passeri, G., Boswell, S. H., Boder, G. B., Williams, D. C., & Manolagas, S. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115668 · Cited by 677 · see citing works

Gonadal Steroids and Immunity*

Olsen, N. J., & Kovacs, W. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-4-369 · Cited by 659 · see citing works

Neuroendocrine-Immune System Interactions and Autoimmunity

Wilder, R. L. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001515 · Cited by 457 · see citing works

Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.

Vamvakopoulos, N. C., & Chrousos, G. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116782 · Cited by 422 · see citing works

Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.

Caulin‐Glaser, T., Watson, C. A., Pardi, R., & Bender, J. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118774 · Cited by 339 · see citing works

Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response

Dalal, M. A., Kim, S., & Voskuhl, R. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.3 · Cited by 293 · see citing works

Estrogens, the immune response and autoimmunity.

Cutolo, M., Sulli, A., SERIOLO, B., Accardo, S., & Masi, A. T. (1995) · PubMed · Cited by 288 · see citing works

Estradiol Down‐Regulates LPS‐Induced Cytokine Production and NFkB Activation in Murine Macrophages

Deshpande, R. R., Khalili, H., Pergolizzi, R. G., Michael, S. D., & Chang, M.-D. Y. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00275.x · Cited by 285 · see citing works

Estrogen up-regulates Bcl-2 and blocks tolerance induction of naïve B cells

Bynoe, M. S., Grimaldi, C. M., & Diamond, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040577497 · Cited by 279 · see citing works

Estrogen enhances immunoglobulin production by human PBMCs

Kanda, N., & Tamaki, K. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70503-8 · Cited by 273 · see citing works

Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells

Araneo, B. A., Dowell, T., Diegel, M. L., & Daynes, R. (1991) · Blood · doi:10.1182/blood.v78.3.688.688 · Cited by 260 · see citing works

Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation.

Sthoeger, Z. M., Chiorazzi, N., & Lahita, R. G. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.1.91 · Cited by 248 · see citing works

CD3+ CD8+ CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause

White, H. D., Crassi, K. M., Givan, A. L., Stern, J. E., Gonzalez, J. L., Memoli, V. A., Green, W. R., & Wira, C. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.3017 · Cited by 233 · see citing works

Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.

Cid, M. C., Kleinman, H. K., Grant, D. S., Schnaper, H. W., Fauci, A. S., & Hoffman, G. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116941 · Cited by 231 · see citing works

Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women

Ralston, S. H., Russell, R. G. G., & Gowen, M. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050912 · Cited by 230 · see citing works

Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells

Kanda, N., Tsuchida, T., & Tamaki, K. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-842.x · Cited by 216 · see citing works

Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies.

Tetlow, L. C., & Woolley, D. E. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.11.896 · Cited by 193 · see citing works

Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors

Medina, K. L., Strasser, A., & Kincade, P. W. (2000) · Blood · doi:10.1182/blood.v95.6.2059 · Cited by 187 · see citing works

A New Mechanism of Bone Destruction in Rheumatoid Arthritis: Synovial Fibroblasts Induce Osteoclastogenesis

Takayanagi, H., Oda, H., Yamamoto, S., Kawaguchi, H., Tanaka, S., Nishikawa, T., & Koshihara, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7404 · Cited by 187 · see citing works

Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.

Staples, J. E., Gasiewicz, T. A., Fiore, N. C., Lubahn, D. B., Korach, K. S., & Silverstone, A. E. (1999) · PubMed · Cited by 184 · see citing works

Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro.

Li, Z. G., Danis, V. A., & Brooks, P. (1993) · PubMed · Cited by 174 · see citing works

Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychosocial stress in healthy young men

Kirschbaum, C., Schommer, N., Federenko, I. S., Gaab, J., Neumann, O., Oellers, M., Rohleder, N., Untiedt, A., Hanker, J. P., Pirke, K., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855815 · Cited by 172 · see citing works

Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor.

Screpanti, I., Morrone, S., Meco, D., Santoni, A., Gulino, A., Paolini, R., Crisanti, A., Mathieson, B. J., & Frati, L. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.10.3378 · Cited by 165 · see citing works

Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.

Fujikawa, Y., Sabokbar, A., Neale, S. D., & Athanasou, N. A. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.11.816 · Cited by 165 · see citing works

Estrogen Receptor α Is Necessary in Thymic Development and Estradiol-Induced Thymic Alterations

Staples, J. E., Gasiewicz, T. A., Fiore, N. C., Lubahn, D. B., Korach, K. S., & Silverstone, A. E. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4168 · Cited by 159 · see citing works

Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MRL lpr/lpr mice

Carlsten, H., Nilsson, N., Jonsson, R., Bäckman, K., Holmdahl, R., & Tarkowski, A. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90236-i · Cited by 156 · see citing works

Inhibition of NFκB Activity through Maintenance of IκBα Levels Contributes to Dihydrotestosterone-mediated Repression of the Interleukin-6 Promoter

Keller, E. T., Chang, C., & Ershler, W. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26267 · Cited by 152 · see citing works

Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis.

Gallucci, W. T., Baum, A. E., Laue, L., Rabin, D. S., Chrousos, G. P., Gold, P. W., & Kling, M. A. (1993) · Health Psychology · doi:10.1037//0278-6133.12.5.420 · Cited by 143 · see citing works

Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells

Sunyer, T., Lewis, J., Collin‐Osdoby, P., & Osdoby, P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4682 · Cited by 139 · see citing works

Corticotropin releasing hormone mRNA is elevated on the afternoon of proestrus in the parvocellular paraventricular nuclei of the female rat

BOHLER, H. C. L., Zoeller, R. T., King, J. C., Rubin, B. S., Weber, R. F. A., & Merriam, G. R. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90025-9 · Cited by 136 · see citing works

Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sj�gren's syndrome

Manoussakis, M. N., Dimitriou, I. D., Kapsogeorgou, E. K., Xanthou, G., Paikos, S., Polihronis, M., & Moutsopoulos, H. Μ. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199902)42:2 · Cited by 134 · see citing works

Testosterone suppresses anti‐DNA antibody production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Kanda, N., Tsuchida, T., & Tamaki, K. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400921 · Cited by 124 · see citing works

Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells.

Suenaga, R., Evans, M. J., Mitamura, K., Rider, V., & Abdou, N. I. (1998) · PubMed · Cited by 122 · see citing works

Androgen and estrogen receptors are present in primary cultures of human synovial macrophages

Cutolo, M., Accardo, S., Villaggio, B., Barone, A. A., Sulli, A., Coviello, D. A., Carabbio, C., Felli, L., Miceli, D., FARRUGGIO, R., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636310 · Cited by 119 · see citing works

Estrogen induces normal murine CD5+ B cells to produce autoantibodies.

Ahmed, S. A., Dauphinée, M. J., Montoya, I. A., & Talal, N. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.8.2647 · Cited by 118 · see citing works

Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis.

Gallucci, W. T., Baum, A. E., Laue, L., et al. (1993) · Health Psychology · doi:10.1037/0278-6133.12.5.420 · Cited by 118 · see citing works

Estradiol Coupling to Human Monocyte Nitric Oxide Release Is Dependent on Intracellular Calcium Transients: Evidence for an Estrogen Surface Receptor

Stefano, G. B., Prévot, V., Beauvillain, J., Fimiani, C., Welters, I. D., Cadet, P., Breton, C., Pestel, J., Salzet, M., & Bilfinger, T. V. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3758 · Cited by 108 · see citing works

Estrogen Decreasesin VitroApoptosis of Peripheral Blood Mononuclear Cells from Women with Normal Menstrual Cycles and Decreases TNF-α Production in SLE but Not in Normal Cultures

Evans, M. J., MacLaughlin, S., Marvin, R. D., & Abdou, N. I. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.4300 · Cited by 96 · see citing works

Hormonal Regulation of Type II Glucocorticoid Receptor Messenger Ribonucleic Acid in Rat Brain*

PEIFFER, R., Lapointe, B. M., & Barden, N. (1991) · Endocrinology · doi:10.1210/endo-129-4-2166 · Cited by 96 · see citing works

Presence of estrogen‐binding sites on macrophage‐like synoviocytes and cd8+, cd29+, cd45ro+ t lymphocytes in normal and rheumatoid synovium

Cutolo, M., Accardo, S., Villaggio, B., Clerico, P., Bagnasco, M., Coviello, D. A., Carruba, G., Casto, M. L., & CASTAGNETTA, L. A. M. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360809 · Cited by 84 · see citing works

Sex hormones and Sjögren's syndrome.

Sullivan, D. A. (1997) · PubMed · Cited by 78 · see citing works

17 beta-estradiol, but not 5 alpha-dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice.

Verthelyi, D. I., & Ahmed, S. A. (1994) · Endocrinology · doi:10.1210/endo.135.6.7988450 · Cited by 76 · see citing works

Hypothalamic-pituitary-mediated immunomodulation: arginine vasopressin is a neuroendocrine immune mediator

Chikanza, I. C., & Grossman, A. (1998) · Lara D. Veeken · doi:10.1093/rheumatology/37.2.131 · Cited by 71 · see citing works

Plasma and Urinary Cortisol in Pregnancy and during Estrogen-Gestagen Treatment

Lindholm, J. (1973) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517309082426 · Cited by 68 · see citing works

The three-way interactions between the hypothalamic-pituitary-adrenal and gonadal axes and the immune system

Torpy, D. J., & Chrousos, G. P. (1996) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(96)80014-8 · Cited by 67 · see citing works

Evidence for the presence of androgen receptors in the synovial tissue of rheumatoid arthritis patients and healthy controls

Cutolo, M., Accardo, S., Villaggio, B., Clerico, P., Indiveri, F., Carruba, G., Fecarotta, E., & CASTAGNETTA, L. A. M. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350905 · Cited by 62 · see citing works

BONE RESORPTION BY TARTRATE-RESISTANT ACID PHOSPHATASE-POSITIVE MULTINUCLEAR CELLS ISOLATED FROM RHEUMATOID SYNOVIUM

Fujikawa, Y., Shingu, M., Torisu, T., Itonaga, I., & Masumi, S. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.3.213 · Cited by 58 · see citing works

Estrogen and progesterone receptors in some human myeloma cell lines and murine hybridomas

Danel, L., Vincent, C., Rousset, F., Klein, B., Bataille, R., Flacher, M., Durie, B. G. M., & Révillard, J. P. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90124-0 · Cited by 53 · see citing works

Expression of estrogen receptor related protein (p29) and estradiol binding in human arthritic synovium.

Ushiyama, T., 井上克枝, & Nishioka, J. (1995) · PubMed · Cited by 47 · see citing works

Androgen metabolism and inhibition of interleukin‐1 synthesis in primary cultured human synovial macrophages

Cutolo, M., Accardo, S., Villaggio, B., Barone, A. A., Sulli, A., Balleari, E., Bason, C., Felli, L., Granata, O. M., Amodio, R., et al. (1995) · Mediators of Inflammation · doi:10.1155/s096293519500024x · Cited by 46 · see citing works

Hormonal modulation of responses to thymus-independent and thymus-dependent antigens in autoimmune NZB/W mice.

Brick, J. E., Wilson, D. A., & Walker, S. E. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.6.3693 · Cited by 45 · see citing works

Estradiol or ovariectomy decreases crf synthesis in hypothalamus

Haas, D. A., & George, S. R. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90150-0 · Cited by 36 · see citing works

Effects of 17β-estradiol and progesterone on migration of human monocytic THP-1 cells stimulated by minimally oxidized low-density lipoprotein in vitro

Okada, M. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00060-6 · Cited by 33 · see citing works

The rate of hyaluronic acid production by human synovial cells studied in tissue culture

Castor, C. W. (1959) · Arthritis & Rheumatism · doi:10.1002/1529-0131(195906)2:3 · Cited by 32 · see citing works

Testosterone metabolism and cyclosporin A treatment in rheumatoid arthritis

Cutolo, M., Giusti, M., Villaggio, B., Barone, A. A., Accardo, S., Sulli, A., Granata, O. M., Carruba, G., & CASTAGNETTA, L. A. M. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.4.433 · Cited by 28 · see citing works

HORMONAL AND IMMUNOLOGIC RISK FACTORS FOR THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: AN INTEGRATIVE PHYSIOPATHOGENETIC PERSPECTIVE

Masi, A. T. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70169-1 · Cited by 25 · see citing works

17 beta-estradiol, but not 5 alpha-dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice

Verthelyi, D. I. (1994) · Endocrinology · doi:10.1210/en.135.6.2615 · Cited by 24 · see citing works

Primary Cultures of Human Synovial Macrophages Metabolize Androgensa

Cutolo, M., Villaggio, B., BARONE, A., Sulli, A., Accardo, S., Granata, O. M., & CASTAGNETTA, L. A. M. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb16277.x · Cited by 21 · see citing works

Supraphysiological level of estrogen exposure in vivo increases lymphoid cell death in mice

Zajchowski, S., & Hoffman‐Goetz, L. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00456-2 · Cited by 20 · see citing works

Immunomodulatory Mechanisms Mediated by Sex Hormones in Rheumatoid Arthritisa

Cutolo, M., & CASTAGNETTA, L. A. M. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb16239.x · Cited by 20 · see citing works

Effects of sex steroids on immunoglobulin M production by Epstein-Barr virus-transformed B-cell line SKW6-CL4

Mori, H., Sawairi, M., Itoh, N., Hanabayashi, T., & Tamaya, T. (1991) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01133023 · Cited by 7 · see citing works

Increase in serum 5 alpha-androstane-3 alpha,17 beta-diol glucuronide as a possible marker of the androgen-mediated immunosuppressive activity exerted by cyclosporin A: preliminary results.

Cutolo, M., Sulli, A., Giusti, M., Barone, A., SERIOLO, B., & Accardo, S. (1994) · PubMed · Cited by 7 · see citing works

The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis

Gravellese (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200002)43:2 · Cited by 2 · see citing works

The complex role of estrogens in inflammation

Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950 · see citing works

The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid Profiles in Hypogonadal Men

Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731 · see citing works

TFOS DEWS II Sex, Gender, and Hormones Report

Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 451 · see citing works

High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome

Janßen, O., Mehlmauer, N., Hahn, S., Offner, A., & Gärtner, R. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500363 · Cited by 322 · see citing works

Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life

Malkin, C. J., Pugh, P. J., Morris, P. D., Kerry, K. E., Jones, R. D., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.021121 · Cited by 250 · see citing works

Neural immune pathways and their connection to inflammatory diseases.

Eskandari, F., Webster, J. I., & Sternberg, E. M. (2003) · Arthritis Research · doi:10.1186/ar1002 · Cited by 201 · see citing works

Androgens and Estrogens Modulate the Immune and Inflammatory Responses in Rheumatoid Arthritis

CUTOLO, M., SERIOLO, B., VILLAGGIO, B., PIZZORNI, C., CRAVIOTTO, C., & SULLI, A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04210.x · Cited by 194 · see citing works

Sjögren's syndrome

Delaleu, N., Jonsson, R., & Koller, M. M. (2005) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2004.00183.x · Cited by 190 · see citing works

Estrogens, osteoarthritis and inflammation

Martín-Millán, M., & Castañeda, S. (2013) · Joint Bone Spine · doi:10.1016/j.jbspin.2012.11.008 · Cited by 166 · see citing works

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.

CASTAGNETTA, L. A. M., Carruba, G., Granata, O. M., Stefano, R., Miele, M., Schmidt, M., Cutolo, M., & Straub, R. H. (2003) · PubMed · Cited by 160 · see citing works

Sex steroids and autoimmune rheumatic diseases: state of the art

Cutolo, M., & Straub, R. H. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0503-4 · Cited by 164 · see citing works

Sex hormones and autoimmunity

González, D. A., Díaz, B. B., Pérez, M. D. C. R., Hernández, A. G., Díaz-Chico, B. N., & de León, A. C. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.07.001 · Cited by 149 · see citing works

Estrogens and the Vascular Endothelium

Cid, M. C., Schnaper, H. W., & Kleinman, H. K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04211.x · Cited by 148 · see citing works

Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample

Byrne, M. L., O’Brien-Simpson, N. M., Reynolds, E. C., Walsh, K. A., Laughton, K., Waloszek, J. M., Woods, M. J., Trinder, J., & Allen, N. B. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.08.010 · Cited by 144 · see citing works

Estrogen and brain inflammation: Effects on microglial expression of MHC, costimulatory molecules and cytokines

Dimayuga, F. O., Reed, J. L., Carnero, G. A., Wang, C., Dimayuga, E. R., Smith, V. D., Perger, A., Wilson, M. E., Keller, J. N., & Bruce‐Keller, A. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.12.016 · Cited by 142 · see citing works

Estrogen metabolism and autoimmunity

Cutolo, M., Sulli, A., & Straub, R. H. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.11.014 · Cited by 140 · see citing works

Sex and Life Expectancy

Seifarth, J., McGowan, C. L. M., & Milne, K. J. (2012) · Gender Medicine · doi:10.1016/j.genm.2012.10.001 · Cited by 139 · see citing works

Brain-immune interactions and disease susceptibility

Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 132 · see citing works

Steroid hormones and disease activity during pregnancy in systemic lupus erythematosus

Doria, A., Cutolo, M., Ghirardello, A., Zampieri, S., Vescovi, F., Sulli, A., Giusti, M., Piccoli, A., Grella, P., & Gambari, P. F. (2002) · Arthritis Care & Research · doi:10.1002/art.10248 · Cited by 130 · see citing works

Sex Hormones and the Genesis of Autoimmunity

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Estradiol Treatment Redirects the Isotype of the Autoantibody Response and Prevents the Development of Autoimmune Arthritis

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Bioavailable testosterone in men with rheumatoid arthritis--high frequency of hypogonadism

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Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

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Sex and gender in psychoneuroimmunology research: Past, present and future

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Gender and Estrogen Manipulation Do Not Affect Traumatic Brain Injury in Mice

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Oestrogens in rheumatic diseases: friend or foe?

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Nociception and role of immune system in pain

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Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1

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Pubertal Status and Age are Differentially Associated with Inflammatory Biomarkers in Female and Male Adolescents

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Neuroimmune Interaction in Inflammatory Diseases

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A Review of the Impact of Neuter Status on Expression of Inherited Conditions in Dogs

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Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats

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Investigating Sleep Disturbances in Adults With Rheumatoid Arthritis

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Increased Severity of Murine Lupus in Female Mice Is Due to Enhanced Expansion of Pathogenic T Cells

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Leptin and ghrelin in Korean systemic lupus erythematosus

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Safety of contraceptive methods for women with rheumatoid arthritis: a systematic review

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Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review

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Anti–interleukin‐6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled study

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Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome

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A Comprehensive Review of Sex Disparities in Symptoms, Pathophysiology, and Epidemiology of Dry Eye Syndrome

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Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis

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Heart Failure as an Inflammatory Condition: Potential Role for Androgens as Immune Modulators

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Outdoor Air Pollution and Pterygium in Korea

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Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?

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Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology

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Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages

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Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line).

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Immune Modulation by Estrogens: Role in CNS HIV-1 Infection

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Nationwide collaborative study of HLA class II associations with distinct types of juvenile chronic arthritis (JCA) in Greece

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Sex Hormones Related Ocular Dryness in Breast Cancer Women

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Annual Research Review: Puberty and the development of anhedonia – considering childhood adversity and inflammation

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Health risk assessment and management as an effective tool to solve issues to ensure the health and epidemiological well-being of the Russian Federation population

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Chronic Stress That Changed Intestinal Permeability and Induced Inflammation Was Restored by Estrogen

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Short-Term Effects of Ground-Level Ozone in Patients With Dry Eye Disease: A Prospective Clinical Study

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Differential Male and Female Adrenal Cortical Steroid Hormone and Cortisol Responses to Interleukin‐6 in Humans

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Down regulation of glucocorticoid receptors in early-diagnosed rheumatoid arthritis.

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HORMONAL AND IMMUNOLOGIC RISK FACTORS FOR THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: AN INTEGRATIVE PHYSIOPATHOGENETIC PERSPECTIVE

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Sex differences in the effect of aging on dry eye disease

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Hormone therapy in rheumatic diseases

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Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives

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Hormone Replacement Therapy and Chronic Graft‐versus‐Host Disease Activity in Women Treated with Bone Marrow Transplantation for Hematologic Malignancies

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Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management

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The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus

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Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach

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The mandibles of castrated male rhesus macaques ( M acaca mulatta): The effects of orchidectomy on bone and teeth

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Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study

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Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4+ cells in mice

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Lupus eritematoso sist?mico

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Role and interactions of annexin A 1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation

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Association of serum total testosterone concentration with skeletal muscle mass in men under hemodialysis

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Preface

Cutolo, M., Bijlsma, J. W. J., Lahita, R. G., Masi, A. T., Straub, R. H., & Bradlow, H. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04195.x · Cited by 16 · see citing works

Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats

Manigrasso, M. B., Sawyer, R. T., Hutchens, Z. M., Flynn, E. R., & Maric‐Bilkan, C. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00569.2011 · Cited by 15 · see citing works

Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuroendocrine-immune Interactions and Evolutionary Biology

STRAUB, R. H., DEL REY, A., & BESEDOVSKY, H. O. (2007) · Psychoneuroimmunology · doi:10.1016/b978-012088576-3/50014-9 · Cited by 14 · see citing works

The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?

Bongiovanni, B., Díaz, A., Santucci, N. E., D’Attilio, L., Bottasso, O. A., Hernández‐Pando, R., & Bay, M. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.892270 · Cited by 14 · see citing works

Sex steroids and autoimmune rheumatic diseases: state of the art

Cutolo, M., & Straub, R. H. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0503-4 · Cited by 164 · see citing works

Chapter 2 Sex Hormones, the Immune System and Autoimmune Diseases

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Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity

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Estrogens and Autoimmune Diseases

Cutolo, M., Capellino, S., Sulli, A., SERIOLI, B., Secchi, M. E., Villaggio, B., & Straub, R. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.043 · Cited by 311 · see citing works

Estrogens and Arthritis

Cutolo, M., & Lahita, R. G. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.10.001 · Cited by 52 · see citing works