The DOI matches its Crossref record; 183 of the 186 references it cites were found in a registry or an index.
Nicotinic receptors in human brain: topography and pathology
Open accessAbstract
Brain nicotinic acetylcholine receptors (nAChR) are a class of ligand-gated channels composed of alpha and beta subunits with specific structural, functional and pharmacological properties. They participate in the physiological and behavioural effects of acetylcholine and mediate responses to nicotine. They are associated with numerous transmitter systems and their expression is altered during development and ageing as well as in diseases such as autism, schizophrenia, Alzheimer's disease, Parkinson's disease and Lewy body dementia. Nicotinic receptors containing a number of different subunits are highly expressed during early human development. Disorders believed to be associated with abnormal brain maturation involve deficits in both alpha4beta2, in the case of autism, and alpha7 possibly in addition to alpha4beta2 nAChRs in the case of schizophrenia. In ageing and age-related neurodegenerative disorders nAChR deficits are predominantly associated with alpha4-containing receptors, although some studies also indicate the involvement of alpha3 and alpha7 subunits. Whilst ageing appears to be associated with reductions in subunit mRNA as well as protein expression, in Alzheimer's disease only protein loss is apparent. Nicotinic therapy may be of benefit in a number of neurological conditions, however studies evaluating further both the distribution of specific subunit involvement and the correlation of nAChR deficits with clinical symptoms are required to inform therapeutic strategy.
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“The heteromeric a4b2* subtype and the homomeric a7 are the most prevalent receptor subtypes in the central nervous system (Court et al., 2000).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Court et al., 2000
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Research works printed but not linked: 1
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Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 678
The dynamic effects of nicotine on the developing brain
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Nicotinic acetylcholine receptors: From basic science to therapeutics
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Self-citation
Metadata
- Authors
- Court, J. A., Martin-Ruiz, C., Graham, A., & Perry, E.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Court, Jenny A.
- ORCID
- Martin-Ruiz, Carmen
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 20
- Issue
- 3-4
- Pages
- 281-298
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W1967131207
- Cited by
- 180
- References
- 186
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 9 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, human brain, receptor subunit expression, alpha4beta2 nAChR, alpha7 nAChR, brain development, brain aging, neurodegeneration, autism spectrum disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies
- MeSH terms
- Brain Chemistry, Brain Diseases, Humans, Receptors, Nicotinic
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