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Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
Open accessAbstract
The laminar cortical distribution of the [125I]alpha-bungarotoxin, [3H]cytisine and [3H]epibatidine nicotinic acetylcholine receptor ligands was investigated by quantitative autoradiography in autopsy tissue from the cingulate, orbitofrontal and temporal cortices of control and schizophrenia subjects matched for age and smoking history. Different laminar binding patterns were observed for the various nicotinic ligands both in schizophrenic and control brains. [125I]alpha-Bungarotoxin binding was distributed homogeneously across all cortical layers in all three brain regions, with highest binding densities in the cingulate cortex. [3H]Cytisine and [3H]epibatidine binding varied across the cortical ribbon, with high binding in layers I, III, V and VI, within the three cortical regions. A significantly reduced [125I] alpha-bungarotoxin binding (-54%) was observed in the cingulate cortex of schizophrenia subjects, in comparison with normal individuals who smoked tobacco. In the same brain region also a significantly higher [3H]cytisine binding (48-77%) was observed in nearly all layers, except for layer I of the schizophrenia subjects, when compared to normal individuals with a history of tobacco use. No significant changes in [3H]epibatidine binding was observed within the individual cortical layers between control subjects and patients with schizophrenia, but when calculated as a whole region (i.e. measurements performed across the whole cortical ribbon), the temporal cortex showed a significant increase in [3H]epibatidine binding in schizophrenia subjects compared to control subjects. The results suggest opposite changes of the alpha4beta2 and alpha7 nicotinic receptor subtypes in the cingulate cortex of patients with schizophrenia which might reflect involvement of two different nicotinic receptor mechanisms in schizophrenia brain.
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“Notably, anomalies in the availability or expression of specific nAChR subunits have been implicated in depression [104] and schizophrenia patients [105, 106].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [106]
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Metadata
- Authors
- Marutle, A., Zhang, X., Court, J., Piggott, M., Johnson, M., Perry, R., Perry, E., & Nordberg, A.
- Affiliations
- Karolinska Institutet (SE)
- Medical Research Council (GB)
- Corresponding author
- Nordberg, Agneta
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 22
- Issue
- 1-2
- Pages
- 115-126
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W2019990977
- Cited by
- 175
- References
- 66
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 12 · 2012: 10
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- schizophrenia, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, alpha7 nicotinic acetylcholine receptor, laminar distribution, cingulate cortex, orbitofrontal cortex, temporal cortex, alpha-bungarotoxin binding, epibatidine binding, smoking, cortical layers
- MeSH terms
- Acetylcholine, Aged, Binding Sites, Brain Chemistry, Bungarotoxins, Cerebral Cortex, Cystine, Female, Humans, Iodine Radioisotopes, Ligands, Male, Middle Aged, Neurons, Pyridines, Radioligand Assay, Receptors, Nicotinic, Schizophrenia, Tobacco Use Disorder, Tritium, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic
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