Cited by 182Nicotinic Acetylcholine Receptors StudySchizophrenia research and treatmentSmoking Behavior and Cessation

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Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

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Marutle, Amelia, Zhang, Xiao, Court, Jennifer, Piggott, Margaret, Johnson, Mary, Perry, Robert, Perry, Elaine, Nordberg, Agneta·2001·Journal of Chemical Neuroanatomy

DOI 10.1016/s0891-0618(01)00117-x

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Abstract

The laminar cortical distribution of the [125I]alpha-bungarotoxin, [3H]cytisine and [3H]epibatidine nicotinic acetylcholine receptor ligands was investigated by quantitative autoradiography in autopsy tissue from the cingulate, orbitofrontal and temporal cortices of control and schizophrenia subjects matched for age and smoking history. Different laminar binding patterns were observed for the various nicotinic ligands both in schizophrenic and control brains. [125I]alpha-Bungarotoxin binding was distributed homogeneously across all cortical layers in all three brain regions, with highest binding densities in the cingulate cortex. [3H]Cytisine and [3H]epibatidine binding varied across the cortical ribbon, with high binding in layers I, III, V and VI, within the three cortical regions. A significantly reduced [125I] alpha-bungarotoxin binding (-54%) was observed in the cingulate cortex of schizophrenia subjects, in comparison with normal individuals who smoked tobacco. In the same brain region also a significantly higher [3H]cytisine binding (48-77%) was observed in nearly all layers, except for layer I of the schizophrenia subjects, when compared to normal individuals with a history of tobacco use. No significant changes in [3H]epibatidine binding was observed within the individual cortical layers between control subjects and patients with schizophrenia, but when calculated as a whole region (i.e. measurements performed across the whole cortical ribbon), the temporal cortex showed a significant increase in [3H]epibatidine binding in schizophrenia subjects compared to control subjects. The results suggest opposite changes of the alpha4beta2 and alpha7 nicotinic receptor subtypes in the cingulate cortex of patients with schizophrenia which might reflect involvement of two different nicotinic receptor mechanisms in schizophrenia brain.

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Authors: Marutle, A., Zhang, X., Court, J., Piggott, M., Johnson, M., Perry, R., Perry, E., & Nordberg, A.
Affiliations: Karolinska Institutet (SE)
Medical Research Council (GB)
Corresponding author: Nordberg, Agneta
ORCID: Zhang, Xiao
Johnson, Mary
Perry, Robert
Nordberg, Agneta
Venue: Journal of Chemical Neuroanatomy
Publisher: Elsevier BV
Published: 2001-07
Volume: 22
Issue: 1-2
Pages: 115-126
ISSN: 0891-0618 (ISSN-L)
DOI: 10.1016/s0891-0618(01)00117-x
OpenAlex: W2019990977
Cited by: 175
References: 66
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 12 · 2012: 10
FWCI: 1.52
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chemical Neuroanatomy (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Vetenskapsrådet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: schizophrenia, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, alpha7 nicotinic acetylcholine receptor, laminar distribution, cingulate cortex, orbitofrontal cortex, temporal cortex, alpha-bungarotoxin binding, epibatidine binding, smoking, cortical layers
MeSH terms: Acetylcholine, Aged, Binding Sites, Brain Chemistry, Bungarotoxins, Cerebral Cortex, Cystine, Female, Humans, Iodine Radioisotopes, Ligands, Male, Middle Aged, Neurons, Pyridines, Radioligand Assay, Receptors, Nicotinic, Schizophrenia, Tobacco Use Disorder, Tritium, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic

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Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

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