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Cited by 143Free Radicals and AntioxidantsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

The reaction of superoxide radical with N-acetylcysteine

Benrahmoune, Mustapha, Thérond, Patrice, Abedinzadeh, Zohreh·2000·Free Radical Biology and Medicine
DOI 10.1016/s0891-5849(00)00380-4
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Abstract

The interaction of superoxide radicals with N-acetylcysteine (RSH) in an aqueous solution of pH 7 using the technique of steady state radiolysis has been investigated in this paper. The radiolytic yield of the products (G value) of RSH consumption and disulfide of N-acetylcysteine (RSSR) formation has been determined. The G value of the products is not dependent on the concentration of RSH (at the plateau of dilution curve) or on the inverse of the square root of the dose rate (dose rate)(-1/2), from which it is concluded that in this reaction there is no character of chain reaction. The disulfide of N-acetylcysteine is the only sulfur final product. Hydrogen peroxide is not a reaction product, and accordingly the reaction of O(2)(*-) with RSH does not proceed via hydrogen atom abstraction from RSH. A reaction mechanism is proposed, and an overall rate constant of 68 M(-1) s(-1) has been estimated.

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Research works printed but not linked: 3

  1. Frick, H.; Hart, E. J. In: Attix, F. H.; Roesch, W. C., eds. Radiation dosimetry. New York: Academic Press; 1966:167–239.
  2. Tamba, 1986, Interactions of thiyl free radicals with oxygen, Int. J. Radiat. Biol., 50, 595
  3. Burns, W. G.; Barker, R. Radiation chemistry, Vol. 3. New York: Pergamon Press; 1965.

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Metadata

Authors
Benrahmoune, M., Thérond, P., & Abedinzadeh, Z.
Affiliations
  • Université Paris Descartes (FR)
  • Hôpital André Mignot (FR)
Corresponding author
Abedinzadeh, Zohreh
ORCID
Thérond, Patrice
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2000-10
Volume
29
Issue
8
Pages
775-782
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/s0891-5849(00)00380-4
OpenAlex
W1996787559
Cited by
143
References
51
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 14 · 2012: 6
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
superoxide, N-acetylcysteine, radiolysis, disulfide bond formation, radiolysis yield, hydrogen abstraction, reaction mechanism, rate constants, chain reaction
MeSH terms
Acetylcysteine, Antioxidants, Gamma Rays, Hydrogen Peroxide, Kinetics, Superoxides, In Vitro Techniques

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