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The reaction of superoxide radical with N-acetylcysteine
Abstract
The interaction of superoxide radicals with N-acetylcysteine (RSH) in an aqueous solution of pH 7 using the technique of steady state radiolysis has been investigated in this paper. The radiolytic yield of the products (G value) of RSH consumption and disulfide of N-acetylcysteine (RSSR) formation has been determined. The G value of the products is not dependent on the concentration of RSH (at the plateau of dilution curve) or on the inverse of the square root of the dose rate (dose rate)(-1/2), from which it is concluded that in this reaction there is no character of chain reaction. The disulfide of N-acetylcysteine is the only sulfur final product. Hydrogen peroxide is not a reaction product, and accordingly the reaction of O(2)(*-) with RSH does not proceed via hydrogen atom abstraction from RSH. A reaction mechanism is proposed, and an overall rate constant of 68 M(-1) s(-1) has been estimated.
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“Cystine and Met do not react with superoxide, but N-acetylcysteine and glutathione GSH do [132,133,134], Figure 49.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [132]
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Metadata
- Authors
- Benrahmoune, M., Thérond, P., & Abedinzadeh, Z.
- Affiliations
- Université Paris Descartes (FR)
- Hôpital André Mignot (FR)
- Corresponding author
- Abedinzadeh, Zohreh
- ORCID
- Thérond, Patrice
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 29
- Issue
- 8
- Pages
- 775-782
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1996787559
- Cited by
- 143
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 14 · 2012: 6
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- superoxide, N-acetylcysteine, radiolysis, disulfide bond formation, radiolysis yield, hydrogen abstraction, reaction mechanism, rate constants, chain reaction
- MeSH terms
- Acetylcysteine, Antioxidants, Gamma Rays, Hydrogen Peroxide, Kinetics, Superoxides, In Vitro Techniques
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