Cited by 143Free Radicals and AntioxidantsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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The reaction of superoxide radical with N-acetylcysteine

Benrahmoune, Mustapha, Thérond, Patrice, Abedinzadeh, Zohreh·2000·Free Radical Biology and Medicine

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Abstract

The interaction of superoxide radicals with N-acetylcysteine (RSH) in an aqueous solution of pH 7 using the technique of steady state radiolysis has been investigated in this paper. The radiolytic yield of the products (G value) of RSH consumption and disulfide of N-acetylcysteine (RSSR) formation has been determined. The G value of the products is not dependent on the concentration of RSH (at the plateau of dilution curve) or on the inverse of the square root of the dose rate (dose rate)(-1/2), from which it is concluded that in this reaction there is no character of chain reaction. The disulfide of N-acetylcysteine is the only sulfur final product. Hydrogen peroxide is not a reaction product, and accordingly the reaction of O(2)(*-) with RSH does not proceed via hydrogen atom abstraction from RSH. A reaction mechanism is proposed, and an overall rate constant of 68 M(-1) s(-1) has been estimated.

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Authors: Benrahmoune, M., Thérond, P., & Abedinzadeh, Z.
Affiliations: Université Paris Descartes (FR)
Hôpital André Mignot (FR)
Corresponding author: Abedinzadeh, Zohreh
ORCID: Thérond, Patrice
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2000-10
Volume: 29
Issue: 8
Pages: 775-782
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(00)00380-4
OpenAlex: W1996787559
Cited by: 143
References: 51
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 14 · 2012: 6
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: superoxide, N-acetylcysteine, radiolysis, disulfide bond formation, radiolysis yield, hydrogen abstraction, reaction mechanism, rate constants, chain reaction
MeSH terms: Acetylcysteine, Antioxidants, Gamma Rays, Hydrogen Peroxide, Kinetics, Superoxides, In Vitro Techniques

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The reaction of superoxide radical with N-acetylcysteine

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