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Cited by 352Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressCardiovascular and exercise physiology

The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index.

Oxidative stress in athletes during extreme endurance exercise

Mastaloudis, Angela, Leonard, Scott W, Traber, Maret G·2001·Free Radical Biology and Medicine
DOI 10.1016/s0891-5849(01)00667-0
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Abstract

Despite the many known health benefits of exercise, there is a body of evidence suggesting that endurance exercise is associated with oxidative stress. To determine whether extreme endurance exercise induces lipid peroxidation, 11 athletes (3 females, 8 males) were studied during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) 1 month later. The evening before each trial, with dinner, subjects consumed 75 mg each d(3)-RRR and d(6)-all rac-alpha-tocopheryl acetates. Blood was obtained at baseline, 30 min pre-race, mid-race, post-race, 1 h post-race, 24 h post-race, and at corresponding times during trial 2. All 11 subjects completed the race; average run time was 391 +/- 23 min. Plasma F(2)-isoprostanes increased from 75 +/- 7 pg/ml at pre-race to 131 +/- 17 (p <.02) at post-race, then returned to baseline at 24 h post-race; F(2)-isoprostanes were unchanged during trial 2. Deuterated alpha-tocopherol disappearance rates were faster (2.8 x 10(-4) +/- 0.2 x 10(-4)) during the race compared to the sedentary trial (2.3 x 10(-4) +/- 0.2 x 10(-4); p <.03). These data suggest that extreme endurance exercise results in the generation of lipid peroxidation with a concomitant increase in vitamin E disappearance.

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Research works printed but not linked: 1

  1. Goodman, 1997, Biochemistry and ultrastructural indices of muscle damage after a 21-km run, Aust. J. Sci. Med. Sport, 29, 95

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Metadata

Authors
Mastaloudis, A., Leonard, S. W., & Traber, M. G.
Affiliations
Oregon State University (US)
Corresponding author
Mastaloudis, Angela
ORCID
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2001-10
Volume
31
Issue
7
Pages
911-922
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/s0891-5849(01)00667-0
OpenAlex
W2033882509
Cited by
352
References
71
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 22 · 2020: 13 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 17 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 18
FWCI
13.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tobacco-Related Disease Research Program
  • National Institute of Environmental Health Sciences (ES-00-210, P30ES000210, R03ES011536)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
oxidative stress, endurance exercise, ultramarathon, lipid peroxidation, F2-isoprostanes, vitamin E, alpha-tocopherol, athletes
MeSH terms
Adult, Ascorbic Acid, Female, Humans, Lipids, Male, Middle Aged, Physical Endurance, Sports, Uric Acid, Vitamin E, Lipid Peroxidation, Exercise, Oxidative Stress, F2-Isoprostanes

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