The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index.
Oxidative stress in athletes during extreme endurance exercise
Abstract
Despite the many known health benefits of exercise, there is a body of evidence suggesting that endurance exercise is associated with oxidative stress. To determine whether extreme endurance exercise induces lipid peroxidation, 11 athletes (3 females, 8 males) were studied during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) 1 month later. The evening before each trial, with dinner, subjects consumed 75 mg each d(3)-RRR and d(6)-all rac-alpha-tocopheryl acetates. Blood was obtained at baseline, 30 min pre-race, mid-race, post-race, 1 h post-race, 24 h post-race, and at corresponding times during trial 2. All 11 subjects completed the race; average run time was 391 +/- 23 min. Plasma F(2)-isoprostanes increased from 75 +/- 7 pg/ml at pre-race to 131 +/- 17 (p <.02) at post-race, then returned to baseline at 24 h post-race; F(2)-isoprostanes were unchanged during trial 2. Deuterated alpha-tocopherol disappearance rates were faster (2.8 x 10(-4) +/- 0.2 x 10(-4)) during the race compared to the sedentary trial (2.3 x 10(-4) +/- 0.2 x 10(-4); p <.03). These data suggest that extreme endurance exercise results in the generation of lipid peroxidation with a concomitant increase in vitamin E disappearance.
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“Moderate levels of exercise enforce the human body's antioxidant defense system, but extreme levels of exercise lead to the generation of more ROS than the antioxidant system can defend against, thereby allowing their accumulation as oxidative stress (Mastaloudis et al., 2001).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Mastaloudis et al., 2001
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Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Åstrand, P., & Rodahl, K. (1970) · Andalas University Repository (Andalas University) · Cited by 4,434
Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.
Dill, D. B., & COSTILL, D. L. (1974) · Journal of Applied Physiology · doi:10.1152/jappl.1974.37.2.247 · Cited by 3,391
Modern Nutrition in Health and Disease.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-508_7 · Cited by 3,381
Free radicals in biology and medicine
Halliwell, B. B., & Gutteridge, J. M. C. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90140-0 · Cited by 2,938
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
Textbook of Work Physiology: Physiological Bases of Exercise
(2004) · Physiotherapy Theory and Practice · doi:10.1080/09593980490425012 · Cited by 1,864
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Cellular mechanisms of muscle fatigue
Fitts, R. H. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.49 · Cited by 1,537
Modern Nutrition in Health and Disease
FELDMAN, E. B. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.948 · Cited by 1,426
Research works printed but not linked: 1
- Goodman, 1997, Biochemistry and ultrastructural indices of muscle damage after a 21-km run, Aust. J. Sci. Med. Sport, 29, 95
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Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547
Self-citationVitamins C and E: Beneficial effects from a mechanistic perspective
Traber, M. G., & Stevens, J. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.017 · Cited by 1,076
Self-citationOxidative stress, exercise, and antioxidant supplementation
Urso, M. L., & Clarkson, P. M. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00151-3 · Cited by 1,067
Oxidative Stress: Relationship with Exercise and Training
Finaud, J., Lac, G., & Filaire, E. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00004 · Cited by 771
Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761
Metadata
- Authors
- Mastaloudis, A., Leonard, S. W., & Traber, M. G.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Mastaloudis, Angela
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 31
- Issue
- 7
- Pages
- 911-922
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2033882509
- Cited by
- 352
- References
- 71
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 22 · 2020: 13 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 17 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 18
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tobacco-Related Disease Research Program
- National Institute of Environmental Health Sciences (ES-00-210, P30ES000210, R03ES011536)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- oxidative stress, endurance exercise, ultramarathon, lipid peroxidation, F2-isoprostanes, vitamin E, alpha-tocopherol, athletes
- MeSH terms
- Adult, Ascorbic Acid, Female, Humans, Lipids, Male, Middle Aged, Physical Endurance, Sports, Uric Acid, Vitamin E, Lipid Peroxidation, Exercise, Oxidative Stress, F2-Isoprostanes
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