The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Determination of Optimal Conditions for Synthesis of Peroxynitrite by Mixing Acidified Hydrogen Peroxide with Nitrite
Abstract
The measured parameters for the formation of peroxynitrous acid via the reaction of acidified hydrogen peroxide with nitrous acid and its self-decomposition corroborate with an earlier suggested mechanism in which H2NO2+ nitrosates H2O2. The activation energies for the formation and decay of peroxynitrous acid have been determined to be 15 and 19 kcal/mol, respectively. We found that perchlorate, nitrate, sulfate and phosphate ions have no effect on the formation and decay rates, whereas chloride ions enhance the rate of the formation of peroxynitrous acid at low peroxide concentrations, and have no effect at high peroxide concentrations. This suggests that at relatively low concentration of H2O2, Cl- competes with H2O2 for H2NO+ to yield NOCl, which may also nitrosate H2O2. Simulation of the experimentally observed parameters for the decay and formation rates suggests that it is not possible to obtain 100% yield of peroxynitrite under any condition. High yields of peroxynitrite were obtained at room temperature using an efficient double mixer where acidified peroxide was mixed with nitrite; after an appropriate delay, the reaction was quenched with strong alkali. An excess of more than 10% of H2O2 over nitrite, or vice versa, is sufficient to get ca. 85-90% of peroxynitrite, almost free from nitrite or H2O2, respectively. The results also suggest that conventional use of ice-cold solutions of the reactants and the alkali solutions is not required if an efficient mixer and appropriate quenching times are available.
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“HO mediates the degradation of heme in mammals. This enzyme catalyzes the degradation of the protoporphyrin IX (heme b) to biliverdin (805, 806).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [806]
In the citing paper
“This enzyme catalyzes the degradation of the protoporphyrin IX (heme b) to biliverdin (805, 806).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [806]
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Cites
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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
[23] Oxidative chemistry of peroxynitrite
Beckman, J. S., Chen, J., Ischiropoulos, H., & Crow, J. P. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33026-3 · Cited by 973
H2O2 Determination by the I3- Method and by KMnO4 Titration
Klassen, N. V., Marchington, D., & Mcgowan, H. (1994) · Analytical Chemistry · doi:10.1021/ac00090a020 · Cited by 967
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Beckman, J. S., & Crow, J. P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210330 · Cited by 674
The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study
Goldstein, S., & Czapski, G. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00034-u · Cited by 398
Self-citationThe chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid
Hughes, M., & Nicklin, H. G. (1968) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19680000450 · Cited by 356
Metabolic Fate of Peroxynitrite in Aqueous Solution
Pfeiffer, S., Gorren, A. C. F., Schmidt, K., Werner, E. R., Hansert, B., Bohle, D. S., & Mayer, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3465 · Cited by 329
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Lukeš, P., Doležalová, E., Sisrová, I. (., & Člupek, M. (2014) · Plasma Sources Science and Technology · doi:10.1088/0963-0252/23/1/015019 · Cited by 1,187
Hydroxyl Radical-Mediated Modification of Proteins as Probes for Structural Proteomics
Xu, G., & Chance, M. R. (2007) · Chemical Reviews · doi:10.1021/cr0682047 · Cited by 680
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer‐Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Álvarez, B., & Radí, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 653
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Neurodegenerative disorders: the role of peroxynitrite
Torreilles, F., Salman-Tabcheh, S., Guérin, M.-C., & Torreilles, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00014-4 · Cited by 430
Metadata
- Authors
- Saha, A., Goldstein, S., Cabelli, D., & Czapski, G.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Brookhaven National Laboratory (US)
- Corresponding author
- Czapski, Gidon
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 24
- Issue
- 4
- Pages
- 653-659
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2079636467
- Cited by
- 143
- References
- 33
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 6 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 2 · 2012: 4
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Physical Organic Chemistry and Reaction Kinetics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- peroxynitrite, peroxynitrous acid, hydrogen peroxide, nitrite, reaction mechanism, activation energy, chloride, nitrosyl chloride, reaction yield optimization, quenching
- MeSH terms
- Cold Temperature, Hydrogen Peroxide, Hydrogen-Ion Concentration, Kinetics, Nitrates, Nitrites, Osmolar Concentration, Perchlorates, Solutions, Thermodynamics, Oxidants
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